Study on inhibitory effect of triterpenoid saponin from Ardisia japonica TSP02 on proliferation and metastasis of human hepatocellular carcinoma cells and its mechanism

Zhongguo Zhongyao Zazhi

Volumn 38, Issue 6, 2013, Pages 861-865

  Zhao, Chen Yang ^a   Hui, Lin Ping ^a   He, Lin ^a   Li, Qin ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Invasiveness; Liver cancer; Triterpenoid saponin from Ardisia japonica

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 8; SAPONIN DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1; TRITERPENOID; TSP 02; UNCLASSIFIED DRUG; UVOMORULIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARDISIA; ARDISIA JAPONICA; ARTICLE; CELL INVASION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; METASTASIS; PROTEIN EXPRESSION; TUMOR INVASION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARDISIA; CARCINOMA, HEPATOCELLULAR; CASPASE 8; CELL CYCLE; CELL PROLIFERATION; ENZYME ACTIVATION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; NEOPLASM METASTASIS; SAPONINS; TRITERPENES; UP-REGULATION;

EID: 84877047861     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20130618     Document Type: Article

References (18)

1. 1981: 586.
2. 2003, 26(2): 144.
3. K Foubert, M Theunis, S Apers, et al. Chemistry, distribution and biological activities of 13,28-epoxy-oleanane saponins from the plant families Myrsinaceae and Primulaceae [J]. Curr Org Chem, 2008, 12: 629.
4. Lin H, Zhang X, heng G, et al. Apoptosis induced by ardipusil-loside III through BAD dephosphorylation and cleavage in human glioblastoma U251MG cells [J]. Apoptosis, 2008, 13: 247.
5. Park J H, Kwak J H, Khoo J H, et al. Cytotoxic effects of triter-penoid saponins from androsace umbellata against multidrug resistance (MDR) and non-MDR cells [J]. Arch Pharm Res, 2010, 33(8): 1175.
6. Li M, Wei S Y, Xu B, et al. Pro-apoptotic and microtubule-dis-assembly effects of ardisiacrispin (A + B), triterpenoid saponins from Ardisia crenata on human hepatoma Bel-7402 cells [J]. J Asian Nat Prod Res, 2008, 10(7/8): 729.
7. Lou L, Ye W, Chen Y, et al. Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells [J]. Phytomedicine, 2012, 19 (7): 603.
8. Chang X, Li W, Jia Z, et al. Biologically active triterpenoid saponins from Ardisia japonica [J]. J Nat Prod, 2007, 70 (2): 179.
9. R Senthil Murugan, R Vidya Priyadarsini, K Ramalingam, et al. Intrinsic apoptosis and NF-κB signaling are potential molecular targets for chemoprevention by black tea polyphenols in HepG2 cells in vitro and in a rat hepatocarcinogenesis model in vivo [J]. Food Chem Toxicol, 2010, 48: 3281.
10. 2005, 20(3): 250.
11. 2012, 34(2): 134.
12. T Bashir, M Pagano. Cdk1, the dominant sibling of Cdk2[J]. Nat Cell Biol, 2005, 7 (8): 779.
13. N Ito, S Kawata, S Tamura, et al. Elevated levels of transforming growth factorbeta and its polypeptide in human hepatocellular carcinoma [J]. Cancer Res, 1991, 51(15): 4080.
14. Bierie B, Moses H L. TGF-beta and cancer[J]. Cytokin Growth Factor Rev, 2006, 17: 29.
15. Arteaga C L. Inhibition of TGFbeta signaling in cancer therapy [J]. Curr Opin Genet Dev, 2006, 16(1): 30.
16. 2009, 24(4): 337.
17. Fransvea E, Angelotti U, Antonaci S, et al. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells [J]. Hepatology, 2008, 47(5): 1557.
18. 2010, 30(1): 64.