A potential antitumor agent, (6-amino-1-methyl-5-nitrosouracilato-N3)- triphenylphosphine-gold(I): Structural studies and in vivo biological effects against experimental glioma

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 260-272

  Illán Cabeza, Nuria A ^a   García García, Antonio R ^a   Martínez Martos, José M ^a   Ramírez Expósito, María J ^a   Peña Ruiz, Tomás ^a   Moreno Carretero, Miguel N ^a  

^a UNIVERSITY OF JAÉN   (Spain)

Author keywords

Antioxidant; Antitumor activity; Gold; Pyrimidine; Uracil

Indexed keywords

(6 AMINO 1 METHY 5 NITROSOURACILATO N3)TRIPHENYLPHOSPHINE GOLD; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CATALASE; CHOLESTEROL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GOLD DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDOREDUCTASE; POTASSIUM; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; URIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER INHIBITION; CANCER MODEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; GLIOMA; IN VIVO STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; POTASSIUM BLOOD LEVEL; RAT; STRUCTURE ACTIVITY RELATION; SUPRAMOLECULAR CHEMISTRY; TREATMENT DURATION; TREATMENT RESPONSE; TUMOR VOLUME; URIC ACID BLOOD LEVEL;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLIOMA; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOGOLD COMPOUNDS; OXIDATIVE STRESS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; URACIL;

EID: 84877045085     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.067     Document Type: Article

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