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Volumn 31, Issue 3, 2013, Pages 444-454

Mechanism of hypertension and proteinuria during angiogenesis inhibition: Evolving role of endothelin-1

Author keywords

Endothelin 1; Hypertension; Nitric oxide; Proteinuria; Rarefaction; Soluble vascular endothelial growth factor type 1 receptor; Vascular endothelial growth factor

Indexed keywords

AFLIBERCEPT; ANGIOGENESIS INHIBITOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ATRASENTAN; BEVACIZUMAB; CALCIUM CHANNEL BLOCKING AGENT; CEDIRANIB; CYCLOHEXIMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; LINIFANIB; MACITENTAN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PAZOPANIB; SODIUM CHLORIDE; SORAFENIB; SUNITINIB; TELATINIB; TEZOSENTAN; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

EID: 84877023514     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32835c1d1b     Document Type: Review
Times cited : (58)

References (120)
  • 2
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • DOI 10.1038/nature04483, PII NATURE04483
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005; 438:967-974. (Pubitemid 43093963)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 3
    • 79959426381 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibitor-induced hypertension: Basics for primary care providers
    • Escalante CP, Zalpour A. Vascular endothelial growth factor inhibitor-induced hypertension: basics for primary care providers. Cardiol Res Pract 2011; 2011:816897.
    • (2011) Cardiol Res Pract , vol.2011 , pp. 816897
    • Escalante, C.P.1    Zalpour, A.2
  • 4
    • 70349685095 scopus 로고    scopus 로고
    • Rapid development of hypertension by sorafenib: Toxicity or target?
    • Humphreys BD, Atkins MB. Rapid development of hypertension by sorafenib: toxicity or target? Clin Cancer Res 2009; 15:5947-5949.
    • (2009) Clin Cancer Res , vol.15 , pp. 5947-5949
    • Humphreys, B.D.1    Atkins, M.B.2
  • 5
    • 82455210240 scopus 로고    scopus 로고
    • Proteinuria and hypertension with tyrosine kinase inhibitors
    • Kandula P, Agarwal R. Proteinuria and hypertension with tyrosine kinase inhibitors. Kidney Int 2011; 80:1271-1277.
    • (2011) Kidney Int , vol.80 , pp. 1271-1277
    • Kandula, P.1    Agarwal, R.2
  • 7
    • 33846638744 scopus 로고    scopus 로고
    • Risks of Proteinuria and Hypertension With Bevacizumab, an Antibody Against Vascular Endothelial Growth Factor: Systematic Review and Meta-Analysis
    • DOI 10.1053/j.ajkd.2006.11.039, PII S0272638606018336
    • Zhu X, Wu S, Dahut WL, Parikh CR. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis 2007; 49:186-193. (Pubitemid 46178407)
    • (2007) American Journal of Kidney Diseases , vol.49 , Issue.2 , pp. 186-193
    • Zhu, X.1    Wu, S.2    Dahut, W.L.3    Parikh, C.R.4
  • 8
    • 40849100423 scopus 로고    scopus 로고
    • Preeclampsia pathogenesis: 'Triple a rating' - Autoantibodies and antiAngiogenic factors
    • DOI 10.1161/HYPERTENSIONAHA.107.100735
    • Karumanchi SA, Lindheimer MD. Preeclampsia pathogenesis: 'triple a rating'-autoantibodies and antiangiogenic factors. Hypertension 2008; 51:991-992. (Pubitemid 351398952)
    • (2008) Hypertension , vol.51 , Issue.4 PART 2 SUPPL. , pp. 991-992
    • Karumanchi, S.A.1    Lindheimer, M.D.2
  • 9
    • 0037373006 scopus 로고    scopus 로고
    • Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    • Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111:649-658.
    • (2003) J Clin Invest , vol.111 , pp. 649-658
    • Maynard, S.E.1    Min, J.Y.2    Merchan, J.3    Lim, K.H.4    Li, J.5    Mondal, S.6
  • 11
    • 77957231200 scopus 로고    scopus 로고
    • Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels
    • Kappers MH, van Esch JHM, Sluiter W, Sleijfer S, Danser AHJ, van den Meiracker AH. Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels. Hypertension 2010; 56:675-681.
    • (2010) Hypertension , vol.56 , pp. 675-681
    • Kappers, M.H.1    Van Esch, J.H.M.2    Sluiter, W.3    Sleijfer, S.4    Danser, A.H.J.5    Van Den Meiracker, A.H.6
  • 12
    • 84864197027 scopus 로고    scopus 로고
    • Linking placental ischemia and hypertension in preeclampsia: Role of endothelin 1
    • George EM, Granger JP. Linking placental ischemia and hypertension in preeclampsia: role of endothelin 1. Hypertension 2012; 60:507-511.
    • (2012) Hypertension , vol.60 , pp. 507-511
    • George, E.M.1    Granger, J.P.2
  • 13
    • 80052038097 scopus 로고    scopus 로고
    • Endothelin: Key mediator of hypertension in preeclampsia
    • George EM, Granger JP. Endothelin: key mediator of hypertension in preeclampsia. Am J Hypertens 2011; 24:964-969.
    • (2011) Am J Hypertens , vol.24 , pp. 964-969
    • George, E.M.1    Granger, J.P.2
  • 14
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • DOI 10.1200/JCO.2002.10.088
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20:4368-4380. (Pubitemid 35266299)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.21 , pp. 4368-4380
    • Dvorak, H.F.1
  • 15
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of antitumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of antitumour activity. Nat Rev Cancer 2008; 8:579-591.
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 16
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • DOI 10.1210/er.2003-0027
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25:581-611. (Pubitemid 39099316)
    • (2004) Endocrine Reviews , vol.25 , Issue.4 , pp. 581-611
    • Ferrara, N.1
  • 17
    • 7444224685 scopus 로고    scopus 로고
    • Integrating the anti-VEGF - A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer
    • Hurwitz H. Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer. Clin Colorectal Cancer 2004; 4 (Suppl 2):S62-S68. (Pubitemid 39440145)
    • (2004) Clinical Colorectal Cancer , vol.4 , Issue.SUPPL. 2
    • Hurwitz, H.1
  • 18
    • 34249294557 scopus 로고    scopus 로고
    • Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
    • DOI 10.1038/nrc2152, PII NRC2152
    • Verheul HM, Pinedo HM. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 2007; 7:475-485. (Pubitemid 46809172)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 475-485
    • Verheul, H.M.W.1    Pinedo, H.M.2
  • 19
    • 83255162010 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF), VEGF receptors and their inhibitors for antiangiogenic tumor therapy
    • Takahashi S. Vascular endothelial growth factor (VEGF), VEGF receptors and their inhibitors for antiangiogenic tumor therapy. Biol Pharm Bull 2011; 34:1785-1788.
    • (2011) Biol Pharm Bull , vol.34 , pp. 1785-1788
    • Takahashi, S.1
  • 20
    • 70349249625 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression
    • Facemire CS, Nixon AB, Griffiths R, Hurwitz H, Coffman TM. Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. Hypertension 2009; 54:652-658.
    • (2009) Hypertension , vol.54 , pp. 652-658
    • Facemire, C.S.1    Nixon, A.B.2    Griffiths, R.3    Hurwitz, H.4    Coffman, T.M.5
  • 22
    • 0029854422 scopus 로고    scopus 로고
    • Genetic analysis of the plasminogen and coagulation system in mice
    • Carmeliet P, Collen D. Genetic analysis of the plasminogen and coagulation system in mice. Haemostasis 1996; 26 (Suppl 4):132-153. (Pubitemid 26417432)
    • (1996) Haemostasis , vol.26 , Issue.SUPPL. 4 , pp. 132-153
    • Carmeliet, P.1    Collen, D.2
  • 23
    • 0032559597 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces endothelial fenestrations in vitro
    • DOI 10.1083/jcb.140.4.947
    • Esser S, Wolburg K, Wolburg H, Breier G, Kurzchalia T, Risau W. Vascular endothelial growth factor induces endothelial fenestrations in vitro. J Cell Biol 1998; 140:947-959. (Pubitemid 28141231)
    • (1998) Journal of Cell Biology , vol.140 , Issue.4 , pp. 947-959
    • Esser, S.1    Wolburg, K.2    Wolburg, H.3    Breier, G.4    Kurzchalia, T.5    Risau, W.6
  • 24
    • 0029010434 scopus 로고
    • Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
    • Roberts WG, Palade GE. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 1995; 108 (Pt 6):2369-2379.
    • (1995) J Cell Sci , vol.108 , Issue.PART 6 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 29
    • 85027955048 scopus 로고    scopus 로고
    • Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor Trap-eye)
    • Stewart MW, Rosenfeld PJ, Penha FM, Wang F, Yehoshua Z, Bueno-Lopez E, Lopez PF. Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor Trap-eye). Retina 2012; 32:434-457.
    • (2012) Retina , vol.32 , pp. 434-457
    • Stewart, M.W.1    Rosenfeld, P.J.2    Penha, F.M.3    Wang, F.4    Yehoshua, Z.5    Bueno-Lopez, E.6    Lopez, P.F.7
  • 30
    • 84860460060 scopus 로고    scopus 로고
    • Bevacizumab for retinopathy of prematurity
    • Stewart MW. Bevacizumab for retinopathy of prematurity. Ophthalmology 2012; 119:1091-1092.
    • (2012) Ophthalmology , vol.119 , pp. 1091-1092
    • Stewart, M.W.1
  • 31
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • Ivy SP, Wick JY, Kaufman BM. An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 2009; 6:569-579.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 33
    • 84857250733 scopus 로고    scopus 로고
    • Intravitreal aflibercept injection for neovascular (wet) age-related macular degeneration
    • Ohr M, Kaiser PK. Intravitreal aflibercept injection for neovascular (wet) age-related macular degeneration. Expert Opin Pharmacother 2012; 13:585-591.
    • (2012) Expert Opin Pharmacother , vol.13 , pp. 585-591
    • Ohr, M.1    Kaiser, P.K.2
  • 34
    • 34250365240 scopus 로고    scopus 로고
    • Mechanisms of adverse effects of anti-VEGF therapy for cancer
    • DOI 10.1038/sj.bjc.6603813, PII 6603813
    • Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer 2007; 96:1788-1795. (Pubitemid 46912024)
    • (2007) British Journal of Cancer , vol.96 , Issue.12 , pp. 1788-1795
    • Kamba, T.1    McDonald, D.M.2
  • 36
    • 78649953614 scopus 로고    scopus 로고
    • Hypertension induced by vascular endothelial growth factor signaling pathway inhibition: Mechanisms and potential use as a biomarker
    • Robinson ES, Khankin EV, Karumanchi SA, Humphreys BD. Hypertension induced by vascular endothelial growth factor signaling pathway inhibition: mechanisms and potential use as a biomarker. Semin Nephrol 2010; 30:591-601.
    • (2010) Semin Nephrol , vol.30 , pp. 591-601
    • Robinson, E.S.1    Khankin, E.V.2    Karumanchi, S.A.3    Humphreys, B.D.4
  • 38
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
    • Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011; 378:1931-1939.
    • (2011) Lancet , vol.378 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3    Kaprin, A.4    Szczylik, C.5    Hutson, T.E.6
  • 41
    • 80051470809 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system
    • Kappers MH, Smedts FM, Horn T, van Esch JHM, Sleijfer S, Leijten F, et al. The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system. Hypertension 2011; 58:295-302.
    • (2011) Hypertension , vol.58 , pp. 295-302
    • Kappers, M.H.1    Smedts, F.M.2    Horn, T.3    Van Esch, J.H.M.4    Sleijfer, S.5    Leijten, F.6
  • 42
    • 77952038495 scopus 로고    scopus 로고
    • Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors
    • Maitland ML, Bakris GL, Black HR, Chen HX, Durand JB, Elliott WJ, et al. Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors. J Natl Cancer Inst 2010; 102:596-604.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 596-604
    • Maitland, M.L.1    Bakris, G.L.2    Black, H.R.3    Chen, H.X.4    Durand, J.B.5    Elliott, W.J.6
  • 43
    • 70349696526 scopus 로고    scopus 로고
    • Ambulatory monitoring detects sorafenib-induced blood pressure elevations on the first day of treatment
    • Maitland ML, Kasza KE, Karrison T, Moshier K, Sit L, Black HR, et al. Ambulatory monitoring detects sorafenib-induced blood pressure elevations on the first day of treatment. Clin Cancer Res 2009; 15:6250-6257.
    • (2009) Clin Cancer Res , vol.15 , pp. 6250-6257
    • Maitland, M.L.1    Kasza, K.E.2    Karrison, T.3    Moshier, K.4    Sit, L.5    Black, H.R.6
  • 44
    • 78650419842 scopus 로고    scopus 로고
    • Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors
    • Robinson ES, Khankin EV, Choueiri TK, Dhawan MS, Rogers MJ, Karumanchi SA, Humphreys BD. Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors. Hypertension 2010; 56:1131-1136.
    • (2010) Hypertension , vol.56 , pp. 1131-1136
    • Robinson, E.S.1    Khankin, E.V.2    Choueiri, T.K.3    Dhawan, M.S.4    Rogers, M.J.5    Karumanchi, S.A.6    Humphreys, B.D.7
  • 46
    • 77949894217 scopus 로고    scopus 로고
    • Clinical course of advanced nonsmall-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599
    • Dahlberg SE, Sandler AB, Brahmer JR, Schiller JH, Johnson DH. Clinical course of advanced nonsmall-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599. J Clin Oncol 2010; 28:949-954.
    • (2010) J Clin Oncol , vol.28 , pp. 949-954
    • Dahlberg, S.E.1    Sandler, A.B.2    Brahmer, J.R.3    Schiller, J.H.4    Johnson, D.H.5
  • 47
    • 60549095633 scopus 로고    scopus 로고
    • Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma
    • Bono P, Elfving H, Utriainen T, Osterlund P, Saarto T, Alanko T, Joensuu H. Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma. Ann Oncol 2009; 20:393-394.
    • (2009) Ann Oncol , vol.20 , pp. 393-394
    • Bono, P.1    Elfving, H.2    Utriainen, T.3    Osterlund, P.4    Saarto, T.5    Alanko, T.6    Joensuu, H.7
  • 48
    • 34447343347 scopus 로고    scopus 로고
    • Hypertension as a predictive factor of Sunitinib activity [1]
    • DOI 10.1093/annonc/mdm184
    • Rixe O, Billemont B, Izzedine H. Hypertension as a predictive factor of sunitinib activity. Ann Oncol 2007; 18:1117. (Pubitemid 47050505)
    • (2007) Annals of Oncology , vol.18 , Issue.6 , pp. 1117
    • Rixe, O.1    Billemont, B.2    Izzedine, H.3
  • 49
    • 60549118166 scopus 로고    scopus 로고
    • Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab
    • Scartozzi M, Galizia E, Chiorrini S, Giampieri R, Berardi R, Pierantoni C, Cascinu S. Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab. Ann Oncol 2009; 20:227-230.
    • (2009) Ann Oncol , vol.20 , pp. 227-230
    • Scartozzi, M.1    Galizia, E.2    Chiorrini, S.3    Giampieri, R.4    Berardi, R.5    Pierantoni, C.6    Cascinu, S.7
  • 51
    • 33750964250 scopus 로고    scopus 로고
    • Terminal ballistics of kinase inhibitors: There are no magic bullets
    • Maitland ML, Ratain MJ. Terminal ballistics of kinase inhibitors: there are no magic bullets. Ann Intern Med 2006; 145:702-703. (Pubitemid 46768848)
    • (2006) Annals of Internal Medicine , vol.145 , Issue.9 , pp. 702-703
    • Maitland, M.L.1    Ratain, M.J.2
  • 52
    • 63049088767 scopus 로고    scopus 로고
    • Renal effects of antiangiogenesis therapy: Update for the internist
    • Gurevich F, Perazella MA. Renal effects of antiangiogenesis therapy: update for the internist. Am J Med 2009; 122:322-328.
    • (2009) Am J Med , vol.122 , pp. 322-328
    • Gurevich, F.1    Perazella, M.A.2
  • 53
    • 77955638572 scopus 로고    scopus 로고
    • Bevacizumab increases risk for severe proteinuria in cancer patients
    • Wu S, Kim C, Baer L, Zhu X. Bevacizumab increases risk for severe proteinuria in cancer patients. J Am Soc Nephrol 2010; 21:1381-1389.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1381-1389
    • Wu, S.1    Kim, C.2    Baer, L.3    Zhu, X.4
  • 54
    • 39649122843 scopus 로고    scopus 로고
    • A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib
    • DOI 10.1093/jnci/djm311
    • Patel TV, Morgan JA, Demetri GD, George S, Maki RG, Quigley M, Humphreys BD. A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib. J Natl Cancer Inst 2008; 100:282-284. (Pubitemid 351480534)
    • (2008) Journal of the National Cancer Institute , vol.100 , Issue.4 , pp. 282-284
    • Patel, T.V.1    Morgan, J.A.2    Demetri, G.D.3    George, S.4    Maki, R.G.5    Quigley, M.6    Humphreys, B.D.7
  • 55
    • 78049401416 scopus 로고    scopus 로고
    • Nephrotoxicities associated with the use of tyrosine kinase inhibitors: A single-center experience and review of the literature
    • Jhaveri KD, Flombaum CD, Kroog G, Glezerman IG. Nephrotoxicities associated with the use of tyrosine kinase inhibitors: a single-center experience and review of the literature. Nephron Clin Pract 2011; 117:c312-c319.
    • (2011) Nephron Clin Pract , vol.117
    • Jhaveri, K.D.1    Flombaum, C.D.2    Kroog, G.3    Glezerman, I.G.4
  • 59
    • 33846515280 scopus 로고    scopus 로고
    • Nephrotic Syndrome After Bevacizumab: Case Report and Literature Review
    • DOI 10.1053/j.ajkd.2006.11.024, PII S0272638606016921
    • George BA, Zhou XJ, Toto R. Nephrotic syndrome after bevacizumab: case report and literature review. Am J Kidney Dis 2007; 49:e23-e29. (Pubitemid 46164815)
    • (2007) American Journal of Kidney Diseases , vol.49 , Issue.2
    • George, B.A.1    Zhou, X.J.2    Toto, R.3
  • 62
    • 33846484966 scopus 로고    scopus 로고
    • Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma
    • DOI 10.1016/S1470-2045(07)70037-2, PII S1470204507700372
    • Frangie C, Lefaucheur C, Medioni J, Jacquot C, Hill GS, Nochy D. Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma. Lancet Oncol 2007; 8:177-178. (Pubitemid 46158384)
    • (2007) Lancet Oncology , vol.8 , Issue.2 , pp. 177-178
    • Frangie, C.1    Lefaucheur, C.2    Medioni, J.3    Jacquot, C.4    Hill, G.S.5    Nochy, D.6
  • 63
    • 0037631361 scopus 로고    scopus 로고
    • Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria
    • DOI 10.1074/jbc.C300012200
    • Sugimoto H, Hamano Y, Charytan D, Cosgrove D, Kieran M, Sudhakar A, Kalluri R. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 2003; 278:12605-12608. (Pubitemid 36800018)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.15 , pp. 12605-12608
    • Sugimoto, H.1    Hamanog, Y.2    Charytan, D.3    Cosgrove, D.4    Kieran, M.5    Sudhakar, A.6    Kalluri, R.7
  • 65
    • 0001397264 scopus 로고
    • The renal glomerular lesions of pre-eclampsia: Electron microscopic studies
    • Pirani CL, Pollak VE, Lannigan R, Folli G. The renal glomerular lesions of pre-eclampsia: electron microscopic studies. Am J Obstet Gynecol 1963; 87:1047-1070.
    • (1963) Am J Obstet Gynecol , vol.87 , pp. 1047-1070
    • Pirani, C.L.1    Pollak, V.E.2    Lannigan, R.3    Folli, G.4
  • 66
    • 0026081916 scopus 로고
    • The renal lesion of preeclampsia revisited
    • Kincaid-Smith P. The renal lesion of preeclampsia revisited. Am J Kidney Dis 1991; 17:144-148.
    • (1991) Am J Kidney Dis , vol.17 , pp. 144-148
    • Kincaid-Smith, P.1
  • 67
    • 0031943236 scopus 로고    scopus 로고
    • VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
    • Hood JD, Meininger CJ, Ziche M, Granger HJ. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 1998; 274:H1054-H1058.
    • (1998) Am J Physiol , vol.274
    • Hood, J.D.1    Meininger, C.J.2    Ziche, M.3    Granger, H.J.4
  • 68
    • 0032730327 scopus 로고    scopus 로고
    • Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway
    • Shen BQ, Lee DY, Zioncheck TF. Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway. J Biol Chem 1999; 274:33057-33063. (Pubitemid 129535347)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.46 , pp. 33057-33063
    • Shen, B.-Q.1    Lee, D.Y.2    Zioncheck, T.F.3
  • 69
    • 0033025662 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells
    • DOI 10.1016/S0008-6363(98)00228-4, PII S0008636398002284
    • Bouloumie A, Schini-Kerth VB, Busse R. Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. Cardiovasc Res 1999; 41:773-780. (Pubitemid 29130642)
    • (1999) Cardiovascular Research , vol.41 , Issue.3 , pp. 773-780
    • Bouloumie, A.1    Schini-Kerth, V.B.2    Busse, R.3
  • 70
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399:601-605.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 71
    • 79959723693 scopus 로고    scopus 로고
    • Contrary effects of the receptor tyrosine kinase inhibitor vandetanib on constitutive and flow-stimulated nitric oxide elaboration in humans
    • Mayer EL, Dallabrida SM, Rupnick MA, Redline WM, Hannagan K, Ismail NS, et al. Contrary effects of the receptor tyrosine kinase inhibitor vandetanib on constitutive and flow-stimulated nitric oxide elaboration in humans. Hypertension 2011; 58:85-92.
    • (2011) Hypertension , vol.58 , pp. 85-92
    • Mayer, E.L.1    Dallabrida, S.M.2    Rupnick, M.A.3    Redline, W.M.4    Hannagan, K.5    Ismail, N.S.6
  • 72
    • 50349101200 scopus 로고    scopus 로고
    • Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor
    • Steeghs N, Gelderblom H, Roodt JO, Christensen O, Rajagopalan P, Hovens M, et al. Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. Clin Cancer Res 2008; 14:3470-3476.
    • (2008) Clin Cancer Res , vol.14 , pp. 3470-3476
    • Steeghs, N.1    Gelderblom, H.2    Roodt, J.O.3    Christensen, O.4    Rajagopalan, P.5    Hovens, M.6
  • 73
    • 83655165286 scopus 로고    scopus 로고
    • Sunitinib-induced systemic vasoconstriction in swine is endothelin mediated and does not involve nitric oxide or oxidative stress
    • Kappers MH, de Beer VJ, Zhou Z, Danser AHJ, Sleijfer S, Duncker DJ, et al. Sunitinib-induced systemic vasoconstriction in swine is endothelin mediated and does not involve nitric oxide or oxidative stress. Hypertension 2012; 59:151-157.
    • (2012) Hypertension , vol.59 , pp. 151-157
    • Kappers, M.H.1    De Beer, V.J.2    Zhou, Z.3    Danser, A.H.J.4    Sleijfer, S.5    Duncker, D.J.6
  • 74
    • 67049132896 scopus 로고    scopus 로고
    • Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to anti-angiogenic therapy in a mouse model?
    • Schor-Bardach R, Alsop DC, Pedrosa I, Solazzo SA, Wang X, Marquis RP, et al. Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to anti-angiogenic therapy in a mouse model? Radiology 2009; 251:731-742.
    • (2009) Radiology , vol.251 , pp. 731-742
    • Schor-Bardach, R.1    Alsop, D.C.2    Pedrosa, I.3    Solazzo, S.A.4    Wang, X.5    Marquis, R.P.6
  • 76
    • 43049085201 scopus 로고    scopus 로고
    • Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation
    • DOI 10.1093/annonc/mdm550
    • Mourad JJ, des Guetz G, Debbabi H, Levy BI. Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation. Ann Oncol 2008; 19:927-934. (Pubitemid 351627309)
    • (2008) Annals of Oncology , vol.19 , Issue.5 , pp. 927-934
    • Mourad, J.-J.1    Des, G.G.2    Debbabi, H.3    Levy, B.I.4
  • 78
    • 80054958029 scopus 로고    scopus 로고
    • Re: Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
    • author reply 1558
    • van den Meiracker AH, Danser AHJ, Sleijfer S, Kappers MH. Re: Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2011; 103:1557; author reply 1558.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1557
    • Van Den Meiracker, A.H.1    Danser, A.H.J.2    Sleijfer, S.3    Kappers, M.H.4
  • 82
    • 77955659816 scopus 로고    scopus 로고
    • Endothelin: Biology and disease
    • Khimji AK, Rockey DC. Endothelin: biology and disease. Cell Signal 2010; 22:1615-1625.
    • (2010) Cell Signal , vol.22 , pp. 1615-1625
    • Khimji, A.K.1    Rockey, D.C.2
  • 83
    • 0025605930 scopus 로고
    • Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
    • Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. Cloning of a cDNA encoding a nonisopeptide-selective subtype of the endothelin receptor. Nature 1990; 348:732-735. (Pubitemid 120015148)
    • (1990) Nature , vol.348 , Issue.6303 , pp. 732-735
    • Sakurai, T.1    Yanagisawa, M.2    Takuwa, Y.3    Miyazaki, H.4    Kimura, S.5    Goto, K.6    Masaki, T.7
  • 85
    • 34247124221 scopus 로고    scopus 로고
    • Endothelin-1-induced signaling pathways in vascular smooth muscle cells
    • Bouallegue A, Daou GB, Srivastava AK. Endothelin-1-induced signaling pathways in vascular smooth muscle cells. Curr Vasc Pharmacol 2007; 5:45-52.
    • (2007) Curr Vasc Pharmacol , vol.5 , pp. 45-52
    • Bouallegue, A.1    Daou, G.B.2    Srivastava, A.K.3
  • 86
    • 65549092226 scopus 로고    scopus 로고
    • ETA receptor blockade with atrasentan prevents hypertension with the multitargeted tyrosine kinase inhibitor ABT-869 in telemetry-instrumented rats
    • Banfor PN, Franklin PA, Segreti JA, Widomski DL, Davidsen SK, Albert DH, et al. ETA receptor blockade with atrasentan prevents hypertension with the multitargeted tyrosine kinase inhibitor ABT-869 in telemetry-instrumented rats. J Cardiovasc Pharmacol 2009; 53:173-178.
    • (2009) J Cardiovasc Pharmacol , vol.53 , pp. 173-178
    • Banfor, P.N.1    Franklin, P.A.2    Segreti, J.A.3    Widomski, D.L.4    Davidsen, S.K.5    Albert, D.H.6
  • 87
    • 0024990479 scopus 로고
    • Plasma endothelin-1 levels in patients with pregnancy-induced hypertension
    • Kamoi K, Sudo N, Ishibashi M, Yamaji T. Plasma endothelin-1 levels in patients with pregnancy-induced hypertension. N Engl J Med 1990; 323:1486-1487. (Pubitemid 20384965)
    • (1990) New England Journal of Medicine , vol.323 , Issue.21 , pp. 1486-1487
    • Kamoi, K.1    Sudo, N.2    Ishibashi, M.3    Yamaji, T.4
  • 89
    • 22144487329 scopus 로고    scopus 로고
    • Plasma nitric oxide, endothelin-1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women
    • DOI 10.1016/j.ijgo.2005.04.018, PII S002072920500295X
    • Baksu B, Davas I, Baksu A, Akyol A, Gulbaba G. Plasma nitric oxide, endothelin-1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women. Int J Gynaecol Obstet 2005; 90:112-117. (Pubitemid 40981947)
    • (2005) International Journal of Gynecology and Obstetrics , vol.90 , Issue.2 , pp. 112-117
    • Baksu, B.1    Davas, I.2    Baksu, A.3    Akyol, A.4    Gulbaba, G.5
  • 91
    • 84857052736 scopus 로고    scopus 로고
    • Angiogenic balance and diagnosis of preeclampsia: Selecting the right VEGF receptor
    • Jha V, Aggarwal PK, Chandel N, Jain V. Angiogenic balance and diagnosis of preeclampsia: selecting the right VEGF receptor. J Hum Hypertens 2012; 26:205-206.
    • (2012) J Hum Hypertens , vol.26 , pp. 205-206
    • Jha, V.1    Aggarwal, P.K.2    Chandel, N.3    Jain, V.4
  • 92
    • 74949098555 scopus 로고    scopus 로고
    • Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats
    • Murphy SR, LaMarca BB, Cockrell K, Granger JP. Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats. Hypertension 2010; 55:394-398.
    • (2010) Hypertension , vol.55 , pp. 394-398
    • Murphy, S.R.1    LaMarca, B.B.2    Cockrell, K.3    Granger, J.P.4
  • 93
    • 0031878495 scopus 로고    scopus 로고
    • Stimulatory interaction between vascular endothelial growth factor and endothelin-1 on each gene expression
    • Matsuura A, Yamochi W, Hirata K, Kawashima S, Yokoyama M. Stimulatory interaction between vascular endothelial growth factor and endothelin-1 on each gene expression. Hypertension 1998; 32:89-95. (Pubitemid 28324130)
    • (1998) Hypertension , vol.32 , Issue.1 , pp. 89-95
    • Matsuura, A.1    Yamochi, W.2    Hirata, K.-I.3    Kawashima, S.4    Yokoyama, M.5
  • 95
    • 0025100874 scopus 로고
    • Release of endothelin from the porcine aorta. Inhibition of endothelium-derived nitric oxide
    • Boulanger C, Lüscher TF. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J Clin Invest 1990; 85:587-590. (Pubitemid 20070070)
    • (1990) Journal of Clinical Investigation , vol.85 , Issue.2 , pp. 587-590
    • Boulanger, C.1    Luscher, T.F.2
  • 97
    • 70349554124 scopus 로고    scopus 로고
    • Alteration of nitric oxide gas on gene expression of endothelin-1 and endothelial nitric oxide synthase by a time- and dose-dependent manner in human endothelial cells
    • Weng YH, Kuo CY, Chiu YW, Kuo ML, Liao SL. Alteration of nitric oxide gas on gene expression of endothelin-1 and endothelial nitric oxide synthase by a time- and dose-dependent manner in human endothelial cells. Chin J Physiol 2009; 52:59-64.
    • (2009) Chin J Physiol , vol.52 , pp. 59-64
    • Weng, Y.H.1    Kuo, C.Y.2    Chiu, Y.W.3    Kuo, M.L.4    Liao, S.L.5
  • 98
    • 0032907028 scopus 로고    scopus 로고
    • Effects of endogenous and exogenous nitric oxide on endothelin-1 production in cultured vascular endothelial cells
    • DOI 10.1016/S0014-2999(98)00806-1, PII S0014299998008061
    • Mitsutomi N, Akashi C, Odagiri J, Matsumura Y. Effects of endogenous and exogenous nitric oxide on endothelin-1 production in cultured vascular endothelial cells. Eur J Pharmacol 1999; 364:65-73. (Pubitemid 29015788)
    • (1999) European Journal of Pharmacology , vol.364 , Issue.1 , pp. 65-73
    • Mitsutomi, N.1    Akashi, C.2    Odagiri, J.3    Matsumura, Y.4
  • 99
    • 0030750722 scopus 로고    scopus 로고
    • Endogenous endothelin modulates blood pressure, plasma volume, and albumin escape after systemic nitric oxide blockade
    • Filep JG. Endogenous endothelin modulates blood pressure, plasma volume, and albumin escape after systemic nitric oxide blockade. Hypertension 1997; 30:22-28. (Pubitemid 27306342)
    • (1997) Hypertension , vol.30 , Issue.1 , pp. 22-28
    • Filep, J.G.1
  • 100
    • 0028876796 scopus 로고
    • In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats
    • Richard V, Hogie M, Clozel M, Loffler BM, Thuillez C. In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats. Circulation 1995; 91:771-775.
    • (1995) Circulation , vol.91 , pp. 771-775
    • Richard, V.1    Hogie, M.2    Clozel, M.3    Loffler, B.M.4    Thuillez, C.5
  • 101
    • 0034124224 scopus 로고    scopus 로고
    • Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo
    • Cardillo C, Kilcoyne CM, Cannon RO 3rd, Panza JA. Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo. Hypertension 2000; 35:1237-1241. (Pubitemid 30413657)
    • (2000) Hypertension , vol.35 , Issue.6 , pp. 1237-1241
    • Cardillo, C.1    Kilcoyne, C.M.2    Cannon III, R.O.3    Panza, J.A.4
  • 104
    • 70349263578 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibitors and hypertension: A central role for the kidney and endothelial factors?
    • Granger JP. Vascular endothelial growth factor inhibitors and hypertension: a central role for the kidney and endothelial factors? Hypertension 2009; 54:465-467.
    • (2009) Hypertension , vol.54 , pp. 465-467
    • Granger, J.P.1
  • 105
    • 33845226686 scopus 로고    scopus 로고
    • Increased Salt-Sensitivity in Endothelial Nitric Oxide Synthase-Knockout Mice
    • DOI 10.1016/j.amjhyper.2006.05.025, PII S0895706106003670
    • Leonard AM, Chafe LL, Montani JP, Van Vliet BN. Increased salt-sensitivity in endothelial nitric oxide synthase-knockout mice. Am J Hypertens 2006; 19:1264-1269. (Pubitemid 44856255)
    • (2006) American Journal of Hypertension , vol.19 , Issue.12 , pp. 1264-1269
    • Leonard, A.M.1    Chafe, L.L.2    Montani, J.-P.3    Van Vliet, B.N.4
  • 106
    • 0034982521 scopus 로고    scopus 로고
    • Role of abnormal nitric oxide systems in salt-sensitive hypertension
    • PII S0895706101020726
    • Manning RD Jr, Hu L, Tan DY, Meng S. Role of abnormal nitric oxide systems in salt-sensitive hypertension. Am J Hypertens 2001; 14:68S-73S. (Pubitemid 32506699)
    • (2001) American Journal of Hypertension , vol.14 , Issue.6 II
    • Manning Jr., R.D.1    Hu, L.2    Tan, D.Y.3    Meng, S.4
  • 107
    • 77956480688 scopus 로고    scopus 로고
    • High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity
    • Kopkan L, Hess A, Huskova Z, Cervenka L, Navar LG, Majid DS. High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity. Am J Physiol Renal Physiol 2010; 299:F656-F663.
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Kopkan, L.1    Hess, A.2    Huskova, Z.3    Cervenka, L.4    Navar, L.G.5    Majid, D.S.6
  • 108
    • 28444465856 scopus 로고    scopus 로고
    • B receptors differentially modulate afferent and efferent arteriolar responses to endothelin
    • DOI 10.1038/sj.bjp.0706412, PII 0706412
    • Inscho EW, Imig JD, Cook AK, Pollock DM. ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin. Br J Pharmacol 2005; 146:1019-1026. (Pubitemid 41722175)
    • (2005) British Journal of Pharmacology , vol.146 , Issue.7 , pp. 1019-1026
    • Inscho, E.W.1    Imig, J.D.2    Cook, A.K.3    Pollock, D.M.4
  • 109
    • 66749106368 scopus 로고    scopus 로고
    • Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism
    • Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med 2009; 15:545-552.
    • (2009) Nat Med , vol.15 , pp. 545-552
    • Machnik, A.1    Neuhofer, W.2    Jantsch, J.3    Dahlmann, A.4    Tammela, T.5    Machura, K.6
  • 110
    • 77149143546 scopus 로고    scopus 로고
    • Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats
    • Machnik A, Dahlmann A, Kopp C, Goss J, Wagner H, van Rooijen N, et al. Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats. Hypertension 2010; 55:755-761.
    • (2010) Hypertension , vol.55 , pp. 755-761
    • Machnik, A.1    Dahlmann, A.2    Kopp, C.3    Goss, J.4    Wagner, H.5    Van Rooijen, N.6
  • 111
    • 41349096436 scopus 로고    scopus 로고
    • Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
    • DOI 10.1089/ars.2007.1989
    • Schulz E, Jansen T, Wenzel P, Daiber A, Munzel T. Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxid Redox Signal 2008; 10:1115-1126. (Pubitemid 351451710)
    • (2008) Antioxidants and Redox Signaling , vol.10 , Issue.6 , pp. 1115-1126
    • Schulz, E.1    Jansen, T.2    Wenzel, P.3    Daiber, A.4    Munzel, T.5
  • 112
    • 75749108585 scopus 로고    scopus 로고
    • Glomerular disturbances in preeclampsia: Disruption between glomerular endothelium and podocyte symbiosis
    • Henao DE, Saleem MA, Cadavid AP. Glomerular disturbances in preeclampsia: disruption between glomerular endothelium and podocyte symbiosis. Hypertens Pregnancy 2010; 29:10-20.
    • (2010) Hypertens Pregnancy , vol.29 , pp. 10-20
    • Henao, D.E.1    Saleem, M.A.2    Cadavid, A.P.3
  • 113
    • 26944451716 scopus 로고    scopus 로고
    • NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases
    • DOI 10.1681/ASN.2004060439
    • Gerke P, Sellin L, Kretz O, Petraschka D, Zentgraf H, Benzing T, Walz G. NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol 2005; 16:1693-1702. (Pubitemid 41716475)
    • (2005) Journal of the American Society of Nephrology , vol.16 , Issue.6 , pp. 1693-1702
    • Gerke, P.1    Sellin, L.2    Kretz, O.3    Petraschka, D.4    Zentgraf, H.5    Benzing, T.6    Walz, G.7
  • 116
    • 33748630761 scopus 로고    scopus 로고
    • Potential deployment of angiotensin I converting enzyme inhibitors and of angiotensin II type 1 and type 2 receptor blockers in cancer chemotherapy
    • Molteni A, Heffelfinger S, Moulder JE, Uhal B, Castellani WJ. Potential deployment of angiotensin I converting enzyme inhibitors and of angiotensin II type 1 and type 2 receptor blockers in cancer chemotherapy. Anticancer Agents Med Chem 2006; 6:451-460. (Pubitemid 44377779)
    • (2006) Anti-Cancer Agents in Medicinal Chemistry , vol.6 , Issue.5 , pp. 451-460
    • Molteni, A.1    Heffelfinger, S.2    Moulder, J.E.3    Uhal, B.4    Castellani, W.J.5
  • 120
    • 84856491321 scopus 로고    scopus 로고
    • Targeting the endothelin axis with atrasentan, in combination with IFN-alpha, in metastatic renal cell carcinoma
    • Groenewegen G, Walraven M, Vermaat J, de Gast B, Witteveen E, Giles R, et al. Targeting the endothelin axis with atrasentan, in combination with IFN-alpha, in metastatic renal cell carcinoma. Br J Cancer 2012; 106:284-289.
    • (2012) Br J Cancer , vol.106 , pp. 284-289
    • Groenewegen, G.1    Walraven, M.2    Vermaat, J.3    De Gast, B.4    Witteveen, E.5    Giles, R.6


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