Vascular endothelial growth factor receptor inhibitor enhances dietary salt-induced hypertension in Sprague-Dawley rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 297, Issue 1, 2009, Pages

  Gu, Jian Wei ^a   Manning Jr , R Davis ^a   Young, Emily ^a   Shparago, Megan ^a   Sartin, Brandi ^a   Bailey, Amelia Purser ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

eNOS; Glomerular microvessel endothelial cells; High salt diet; Renal injury; Renal proximal tubular epithelial cells; SU5416; VEGF

Indexed keywords

ALBUMIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; SEMAXANIB; SODIUM CHLORIDE; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; HIGH SODIUM INTAKE; HUMAN; HUMAN CELL; HYPERTENSION; JUXTAGLOMERULAR CELL; KIDNEY INJURY; KIDNEY TUBULE CELL; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN URINE LEVEL; RAT; SODIUM URINE LEVEL; SPRAGUE DAWLEY RAT;

ALBUMINURIA; ANGIOGENESIS INHIBITORS; ANIMALS; BLOOD PRESSURE; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; EPITHELIAL CELLS; HEART RATE; HUMANS; HYPERTENSION; INDOLES; INJECTIONS, INTRAPERITONEAL; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES, PROXIMAL; MALE; NATRIURESIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN KINASE INHIBITORS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SODIUM CHLORIDE, DIETARY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67650093448     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90972.2008     Document Type: Article

References (36)

1. Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, Gerber HP, Kikkawa Y, Miner JH, Quaggin SE. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal disease. J Clin Invest 111: 707-716, 2003. (Pubitemid 36278589)
2. Eremina V, Cui S, Gerber H, Ferrara N, Haigh J, Nagy A, Ema M, Rossant J, Jothy S, Miner JH, Quaggin SE. Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol 17: 724-735, 2006.
3. Fan L, Wakayama T, Yokoyama S, Amano O, Iseki S. Downregulation of vascular endothelial growth factor and its receptors in the kidney in rats with puromycin aminonucleoside nephrosis. Nephron 90: 95-102, 2002. (Pubitemid 34042847)
4. Ferrara N. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 56: 794-814, 1999. (Pubitemid 29411709)
5. Fiedler W, Serve H, Dohner H, Schwittay M, Ottmann OG, O'Farrell AM, Bello CL, Allred R, Manning WC, Cherrington JM, Louie SG, Hong W, Brega NM, Massimini G, Scigalla P, Berdel WE, Hossfeld DK. A phase I study of SU11248 in the treatment of patients with refractory of resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 105: 986-993, 2005. (Pubitemid 40170865)
6. Gu JW, Bailey AP, Sartin A, Makey I, Brady AL. Ethanol stimulates tumor progression and expression of vascular endothelial growth factor in chick embryos. Cancer 103: 422-431, 2005. (Pubitemid 40129304)
7. Gu JW, Bailey AP, Tan Wei Shparago M, Young E. Long-term high-salt diet causes hypertension and decreases renal expression of vascular endothelial growth factor in Sprague-Dawley rats. J Am Soc Hypertens 2: 275-285, 2008.
8. Gu JW, Tian N, Shparago M, Tan W, Bailey AP, Manning RD Jr. Renal NF- B activation and TNF-α upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol 291: R1817-R1824, 2006. (Pubitemid 44904151)
9. Hara A, Wada T, Furuichi K, Sakai N, Kawachi H, Shimizu F, Shibuya M, Matsushima K, Yokoyama H, Egashira K, Kaneko S. Blockade of VEGF accelerates proteinuria, via decrease in nephrin expression in rat crescentic glomerulonephritis. Kidney Int 69: 1986-1995, 2006. (Pubitemid 43924262)
10. Herrera M, Garvin JL. Recent advances in the regulation of nitric oxide in the kidney. Hypertension 45: 1062-1067, 2005. (Pubitemid 40770304)
11. Holden SN, Eckhardt SG, Basser R, de Boer R, Rischin D, Green M, Rosenthal MA, Wheeler C, Barge A, Hurwitz HI. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol 16: 1391-1397, 2005. (Pubitemid 41158486)
12. Honkanen EO, Teppo AM, Gronhagen-Riska C. Decreased urinary excretion of vascular endothelial growth factor in idiopathic membranous glomerulo-nephritis. Kidney Int 57: 2343-2349, 2000. (Pubitemid 30340733)
13. Hornig C, Barleon B, Ahmad S, Vuorela P, Ahmed A, Weich HA. Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids. Lab Invest 80: 443-454, 2000. (Pubitemid 30226626)
14. Kang DH, Kim YG, Andoh TF, Gordon KL, Suga SI, Mazzali M, Jefferson JA, Hughes J, Bennett W, Schreiner GF, Johnson R. Postcyclosporin-mediated hypertension and nephropathy: amelioration by vascular endothelial growth factor. Am J Physiol Renal Physiol 280: F727-F736, 2001. (Pubitemid 32473270)
15. Kang DH, Hughes J, Mazzali M, Schreiner GF, Johnson R. Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 12: 1448-1457, 2001. (Pubitemid 32666327)
16. Kone BC. Nitric oxide synthesis in the kidney: isoforms, biosynthesis, and functions in health. Semin Nephrol 24: 299-315, 2004. (Pubitemid 38900630)
17. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of pre-eclampsia. N Engl J Med 350: 672-683, 2004. (Pubitemid 38364626)
18. Majid DSA, Nishiyama A, Jackson KE, Castillo A. Inhibition of nitric oxide synthase enhances superoxide activity in canine kidney. Am J Physiol Regul Integr Comp Physiol 287: R27-R32, 2004. (Pubitemid 38856307)
19. Rebecca RF, Rachel H, Karen A, et al. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol 284: F1263-F1273, 2003. (Pubitemid 36578454)
20. Makino A, Skelton MM, Zou AP, Roman RJ, Cowley AW Jr. Increased renal medullary oxidative stress produces hypertension. Hypertension 39: 667-672, 2002. (Pubitemid 34165203)
21. Roy H, Bhardwaj S, Yla-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett 580: 2879-2887, 2006. (Pubitemid 43729175)
22. Sandler AB, Johnson DH, Hertst RS. Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer. Clin Cancer Res 10: 4258s-4262s, 2004. (Pubitemid 38812458)
23. Schrijvers BF, Flyvbjerg A, DeVriese AS. The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int 65: 2003-2017, 2004.
24. Shibata E, Rajakumar A, Powers RW, Larkin RW, Gilmour C, Bodnar LM, Crombleholme WR, Ness RB, Roberts JM, Hubel CA. Soluble fms-like tyrosine kinase 1 is increased in pre-eclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor. J Clin Endocrinol Metab 90: 4895-4903, 2005. (Pubitemid 41159388)
25. Siegel AK, Kossmehl P, Planert M, Schulz A, Wehland M, Stoll M, Bruijn JA, de Heer E, Kreutz R. Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on a high-salt diet: comparison with spontaneously hypertensive rats. Physiol Genomics 18: 218-225, 2004. (Pubitemid 39319502)
26. Sugimoto H, Hamano Y, Charyta D, Cosgrove D, Kieran M, Sudhakar A, Kalluri R. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 278: 12605-12608, 2003. (Pubitemid 36800018)
27. Sullivan JC, Smart EJ, Pollock DM, Pollock JS. Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla. Clin Exp Pharmacol Physiol 35: 120-125, 2008.
28. Thomas AL, Morgan B, Drevs J, Unger C, Wiedenmann B, Vanhoefer U, Laurent D, Dugan M, Steward WP. Vascular endothelial growth factor receptor tyrosine kinase inhibitors: PTK787/ZK 222584. Semin Oncol 30, Suppl 6: 32-38, 2003. (Pubitemid 36712857)
29. Thomas S, Vanuystel J, Gruden G, Rodriquez V, Burt D, Hartley B, Viberti G. Vascular endothelial growth factor receptors in human mesangium in vitro and in glomerular disease. J Am Soc Nephrol 11: 1236-1243, 2000. (Pubitemid 30416219)
30. Toback FG. Regeneration after acute tubular necrosis. Kidney Int 41: 226-246, 1996.
31. Villegas G, Lange-Sperandio B, Tufro A. Autocrine and paracrine functions of vascular endothelial growth factor (VEGF) in renal tubular epithelial cells. Kidney Int 67: 449-457, 2005. (Pubitemid 40139836)
32. Wolf G, Chen S, Ziyadeh F. From the periphery of the glomerular capillary wall toward the center of disease. Podocyte injury comes of age in diabetic nephropathy. Diabetes 54: 1626-1634, 2005. (Pubitemid 40770751)
33. Yang L, Li X, Wang H. Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis. Nephrol Dial Transplant 22: 445-456, 2007. (Pubitemid 46189888)
34. Yuan HT, Li XZ, Pitera JE, Long DA, Woolf AS. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia inducible factor-1α. Am J Pathol 163: 2289-2301, 2003. (Pubitemid 37466473)
35. Zangari M, Anaissie E, Stopeck A, Morimoto A, Tan N, Lancet J, Cooper M, Hannah A, Garcia-Manero G, Faderl S, Kantarjian H, Cherrington J, Albitar M, Giles FJ. Phase II study of SU5416, a small molecular vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma. Clin Cancer Res 10: 88-95, 2004. (Pubitemid 38114166)
36. Zhou MS, Schuman IH, Jaimes EA, Raji L. Renoprotection by statins is linked to a decrease in renal oxidative stress, TGF-β, and fibronectin with concomitant increase in nitric oxide bioavailability. Am J Physiol Renal Physiol 295: F53-F59, 2008.