Olfactory epithelium biosensor: Odor discrimination of receptor neurons from a bio-hybrid sensing system

Biomedical Microdevices

Volumn 14, Issue 6, 2012, Pages 1055-1061

  Liu, Qingjun ^a,b   Hu, Ning ^a   Zhang, Fenni ^a   Zhang, Diming ^a   Hsia, K Jimmy ^b   Wang, Ping ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b University of Illinois at Urbana Champaign   (United States)

Author keywords

Bio hybrid sensor; Cell based biosensor; Microelectrode array (MEA); Olfactory epithelium; Receptor neuron

Indexed keywords

ACETONE; BIOSENSORS; ELECTROPHYSIOLOGY; ENVIRONMENTAL TECHNOLOGY; FREQUENCY DOMAIN ANALYSIS; HYBRID SYSTEMS; MICROELECTRODES; NEURONS; ODORS;

CELL-BASED BIOSENSOR; ELECTROPHYSIOLOGICAL ACTIVITY; ENVIRONMENTAL MONITORING; MICROELECTRODE ARRAY; OLFACTORY EPITHELIUMS; OLFACTORY RECEPTOR NEURONS; TEMPORAL CHARACTERISTICS; TIME AND FREQUENCY DOMAINS;

ELECTRONIC NOSE;

2,3 BUTANEDIONE; ACETIC ACID; ACETONE; ETHER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSENSOR; CONTROLLED STUDY; IN VITRO STUDY; MICROARRAY ANALYSIS; MICROELECTRODE ARRAY; NONHUMAN; OLFACTORY DISCRIMINATION; OLFACTORY EPITHELIUM BIOSENSOR; OLFACTORY RECEPTOR; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; SENSORY ANALYSIS; SENSORY NERVE CONDUCTION; SENSORY STIMULATION; SENSORY SYSTEM ELECTROPHYSIOLOGY; SIGNAL DETECTION; SIGNAL TRANSDUCTION; ANIMAL; CHIMERA; CYTOLOGY; ELECTROPHYSIOLOGY; GENETIC PROCEDURES; INSTRUMENTATION; METABOLISM; METHODOLOGY; MICROELECTRODE; NERVE CELL; ODOR; OLFACTORY EPITHELIUM; PHYSIOLOGY; SMELLING; SPRAGUE DAWLEY RAT;

ANIMALS; BIOSENSING TECHNIQUES; CHIMERA; ELECTROPHYSIOLOGICAL PHENOMENA; MICROELECTRODES; NEURONS; ODORS; OLFACTORY MUCOSA; OLFACTORY PERCEPTION; OLFACTORY RECEPTOR NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84877023389     PISSN: 13872176     EISSN: 15728781     Source Type: Journal    
DOI: 10.1007/s10544-012-9705-0     Document Type: Article

References (29)

1. D.R. Albrecht, V.L. Tsang, R.L. Sah, S.N. Bhatia, Photo-and electropatterning of hydrogel-encapsulated living cell arrays. Lab Chip 5, 111-118 (2005)
2. M.F. Bear, B.W. Connors, M.A. Paradiso, Neuroscience: Exploring the brain. (Lippincott Williams & Wilkins, 2007)
3. L.B. Buck, Olfactory receptors and odor coding in mammals. Nutr. Rev. 62, S184-S188 (2004)
4. L. Buck, R. Axel, A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175-187 (1991)
5. A.W. Daus, P.G. Layer, C. Thielemann, A spheroid-based biosensor for the label-free detection of drug-induced field potential alterations. Sensors Actuators B Chem. 165, 53-58 (2012)
6. S. Firestein, How the olfactory system makes sense of scents. Nature 413, 211-218 (2001)
7. M. Frega, V. Pasquale, M. Tedesco, M. Marcoli, A. Contestabile, M. Nanni, L. Bonzano, G. Maura, M. Chiappalone, Cortical cultures coupled to micro-electrode arrays: a novel approach to perform in vitro excitotoxicity testing. Neurotoxicol. Teratol. 34, 116-127 (2011)
8. R. Glatz, K. Bailey-Hill, Mimicking nature's noses: from receptor deorphaning to olfactory biosensing. Prog. Neurobiol. 93, 270-296 (2011)
9. W. Gopel, C. Ziegler, H. Breer, D. Schild, R. Apfelbach, J. Joerges, R. Malaka, Bioelectronic noses: a status report part I. Biosens. Bionelectron. 13, 479-493 (1998)
10. A. Hierlemann, U. Frey, S. Hafizovic, F. Heer, Growing cells atop microelectronic chips: interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays". Proc. IEEE 99(2), 252-284 (2011)
11. C.T. Ho, R.Z. Lin, W.Y. Chang, H.Y. Chang, C.H. Liu, Rapid heterogeneous liver-cell on-chip patterning via the enhanced field-induced dielectrophoresis trap. Lab Chip 6, 724-734 (2006)
12. I. Ito, S. Watanabe, Y. Kirino, Air movement evokes electro-olfactogram oscillations in the olfactory epithelium and modulates olfactory processing in a slug. J. Neurophysiol. 96, 1939-1948 (2006)
13. E. Josephson, S. Yilma, V. Vodyanoy, E. Morrison, Structure and function of long-lived olfactory organotypic cultures from postnatal mice. J. Neurosci. Res. 75, 642-653 (2004)
14. H.J. Ko, T.H. Park, Piezoelectric olfactory biosensor: ligand specificity and dose-dependence of an olfactory receptor expressed in a heterologous cell system. Biosens. Bioelectron. 20, 1327-1332 (2005)
15. S.H. Lee, S.B. Jun, H.J. Ko, S.J. Kim, T.H. Park, Cell-based olfactory biosensor using microfabricated planar electrode. Biosens. Bionelectron. 24, 2659-2664 (2009)
16. Q. Liu, H. Cai, Y. Xu, Y. Li, R. Li, P. Wang, Olfactory cell-based biosensor: a first step towards a neurochip of bioelectronic nose. Biosens. Bionelectron. 22, 318-322 (2006)
17. Q. Liu, W. Ye, L. Xiao, L. Du, N. Hu, P. Wang, Extracellular potentials recording in intact olfactory epithelium by microelectrode array for a bioelectronic nose. Biosens. Bionelectron. 25, 2212-2217 (2010)
18. P.M. Lledo, G. Gheusi, J.D. Vincent, Information processing in the mammalian olfactory system. Physiol. Rev. 85, 281-317 (2005)
19. C.A. Lowry, L.M. Kay, Chemical factors determine olfactory system beta oscillations in waking rats. J. Neurophysiol. 98, 394-404 (2007)
20. M. Marrakchi, J. Vidic, N. Jaffrezic-Renault, C. Martelet, E. Pajot-Augy, A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40. Eur. Biophys. J. 36, 1015-1018 (2007)
21. U.J. Meierhenrich, J. Golebiowski, X. Fernandez, D. Cabrol-Bass, The molecular basis of olfactory chemoreception. Angew. Chem. Int. Ed. 43, 6410-6412 (2004)
22. N. Misawa, H. Mitsuno, R. Kanzaki, S. Takeuchi, Highly sensitive and selective odorant sensor using living cells expressing insect olfactory receptors. Proc. Nat. Acad. Sci. 107, 15340-15344 (2010)
23. P. Nef, I. Hermans-Borgmeyer, H. Artieres-Pin, L. Beasley, V.E. Dionne, S.F. Heinemann, Spatial pattern of receptor expression in the olfactory epithelium. Proc. Nat. Acad. Sci. 89, 8948-8952 (1992)
24. W.T. Nickell, N.K. Kleene, S.J. Kleene, Mechanisms of neuronal chloride accumulation in intact mouse olfactory epithelium. J. Physiol. 583, 1005-1020 (2007)
25. J. Niessing, R.W. Friedrich, Olfactory pattern classification by discrete neuronal network states. Nature 465, 47-52 (2010)
26. T.H. Park, M.L. Shuler, Integration of cell culture and microfabrication technology. Biotechnol. Progr. 19, 243-253 (2003)
27. F. Rock, N. Barsan, U. Weimar, Electronic nose: current status and future trends. Chem. Rev. 108, 705-725 (2008)
28. A.S. Rudolph, J. Reasor, Cell and tissue based technologies for environmental detection and medical diagnostics. Biosens. Bioelectron. 16, 429-431 (2001)
29. P. Wang, Q. Liu, Cell-based biosensors: principles and applications (Artech House Publishers, USA, 2009)