Glutamine synthetase, heat shock protein-70, and glypican-3 in intrahepatic cholangiocarcinoma and tumors metastatic to liver

Applied Immunohistochemistry and Molecular Morphology

Volumn 21, Issue 3, 2013, Pages 254-257

  Lagana, Stephen M ^a   Moreira, Roger K ^a   Remotti, Helen E ^a   Bao, Fei ^a  

^a Department of Medicine   (United States)

Author keywords

cholangiocarcinoma; glutamine synthetase; glypican 3; heat shock protein 70; hepatocellular carcinoma; immunohistochemistry; metastatic tumors liver

Indexed keywords

ANTIBODY; GLUTAMATE AMMONIA LIGASE; GLYPICAN 3; HEAT SHOCK PROTEIN 70;

ARTICLE; BILE DUCT CARCINOMA; BLASTOMA; BREAST ADENOCARCINOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; DUODENUM CARCINOMA; ENDOCRINE TUMOR; ENZYME REACTIVATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MELANOMA; NEUROENDOCRINE DISEASE; PANCREAS TUMOR; PRIORITY JOURNAL; TISSUE MICROARRAY; TUMOR CELL;

BIOPSY, FINE-NEEDLE; CARCINOMA, HEPATOCELLULAR; CHOLANGIOCARCINOMA; GENE EXPRESSION; GLUTAMATE-AMMONIA LIGASE; GLYPICANS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LIVER; LIVER NEOPLASMS; NEOPLASM METASTASIS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84877000925     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e3182642c9c     Document Type: Article

References (15)

1. Di Tommaso L, Franchi G, Park YN, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology (Baltimore, MD). 2007;45:725-734.
2. Di Tommaso L, Destro A, Seok JY, et al. The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma. J Hepatol. 2009;50: 746-754.
3. Wang FH, Yip YC, Zhang M, et al. Diagnostic utility of glypican-3 for hepatocellular carcinoma on liver needle biopsy. J Clin Pathol. 2010;63:599-603.
4. Kalogeraki A, Giannikaki E, Tzardi M, et al. Correlation of heat shock protein (HSP70) expression with cell proliferation (MIB1), estrogen receptors (ER) and clinicopathological variables in invasive ductal breast carcinomas. J Exp Clin Cancer Res. 2007;26:367-368.
5. Wataba K, Saito T, Fukunaka K, et al. Over-expression of heat shock proteins in carcinogenic endometrium. Int J Cancer. 2001;91:448-456.
6. Sagol O, Tuna B, Coker A, et al. Immunohistochemical detection of pS2 protein and heat shock protein-70 in pancreatic adenocarcinomas. Relationship with disease extent and patient survival. Pathol Res Pract. 2002;198:77-84.
7. Sempoux C, Jibara G, Ward SC, et al. Intrahepatic cholangiocarcinoma: new insights in pathology. Semin Liver Dis. 2011;31:49-60.
8. Edge SB, American Joint Committee on Cancer. AJCC Cancer Staging Manual. 7th ed. New York: Springer; 2010.
9. Austinat M, Dunsch R, Wittekind C, et al. Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma. Mol Cancer. 2008;7:21.
10. Audard V, Cavard C, Richa H, et al. Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas. Pancreas. 2008;36:80-83.
11. McCormick D, McQuaid S, McCusker C, et al. A study of glutamine synthetase in normal human brain and intracranial tumours. Neuropathol Appl Neurobiol. 1990;16:205-211.
12. Yamauchi N, Watanabe A, Hishinuma M, et al. The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. Mod Pathol. 2005;18:1591-1598.
13. Nassar A, Cohen C, Siddiqui MT. Utility of glypican-3 and survivin in differentiating hepatocellular carcinoma from benign and preneoplastic hepatic lesions and metastatic carcinomas in liver fine-needle aspiration biopsies. Diagn Cytopathol. 2009;37:629-635.
14. Ligato S, Mandich D, Cartun RW. Utility of glypican-3 in differentiating hepatocellular carcinoma from other primary and metastatic lesions in FNA of the liver: an immunocytochemical study. Mod Pathol. 2008;21:626-631.
15. Zynger DL, Dimov ND, Luan C, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006;30: 1570-1575.