Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults

Journal of Nutrition

Volumn 143, Issue 5, 2013, Pages 606-612

  Alfred, Tamuno ^a   Ben Shlomo, Yoav ^a   Cooper, Rachel ^b   Hardy, Rebecca ^b   Deary, Ian J ^c   Elliott, Jane ^d   Harris, Sarah E ^c   Hyppönen, Elina ^e   Kivimaki, Mika ^b   Kumari, Meena ^b   Maddock, Jane ^e   Power, Chris ^e   Starr, John M ^c   Kuh, Diana ^b   Day, Ian N M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF LONDON   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; BETA CAROTENE 15,15' MONOOXYGENASE; BIOLOGICAL MARKER; CYANOCOBALAMIN; FUCOSYLTRANSFERASE; HEMOGLOBIN A1C; HFE PROTEIN; IRON; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRANSMEMBRANE PROTEASE SERINE 6; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D BINDING PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; COGNITION; COHORT ANALYSIS; CONCENTRATION (PARAMETERS); FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); MIDDLE AGED; NUTRITION; OBSERVATIONAL STUDY; PHONEME; SEMANTICS; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM; VERBAL MEMORY; WORD RECOGNITION;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; BIOLOGICAL MARKERS; COGNITION; COGNITION DISORDERS; FEMALE; GENOTYPE; GREAT BRITAIN; HEMOCHROMATOSIS; HUMANS; IRON; MALE; MENTAL RECALL; MICRONUTRIENTS; MIDDLE AGED; NUTRITIONAL STATUS; POLYMORPHISM, GENETIC; VITAMIN D; VITAMIN D-BINDING PROTEIN;

EID: 84876978985     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.171520     Document Type: Article

References (64)

1. Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC. Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr. 2000;72:912-21.
2. Haveman-Nies A, de Groot LPGM, Burema J, Cruz JAA, Osler M, van Staveren WA. Dietary quality and lifestyle factors in relation to 10-year mortality in older Europeans: the SENECA study. Am J Epidemiol. 2002;156:962-8.
3. Huijbregts P, Feskens E, Räsänen L, Fidanza F, Nissinen A, Menotti A, Kromhout D. Dietary pattern and 20 year mortality in elderly men in Finland, Italy, and The Netherlands: longitudinal cohort study. BMJ. 1997;315:13-7.
4. Del Parigi A, Panza F, Capurso C, Solfrizzi V. Nutritional factors, cognitive decline, and dementia. Brain Res Bull. 2006;69:1-19.
5. Deary IJ, Corley J, Gow AJ, Harris SE, Houlihan LM, Marioni RE, Penke L, Rafnsson SB, Starr JM. Age-associated cognitive decline. Br Med Bull. 2009;92:135-52.
6. Hermoso M, Vucic V, Vollhardt C, Arsic A, Roman-Vinas B, Iglesia- Altaba I, Gurinovic M, Koletzko B. The effect of iron on cognitive development and function in infants, children and adolescents: a systematic review. Ann Nutr Metab. 2011;59:154-65.
7. Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr. 2002;75:908-13.
8. Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010;170:1135-41.
9. Llewellyn DJ, Lang IA, Langa KM, Melzer D. Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol A Biol Sci Med Sci. 2011;66:59-65.
10. Jama JW, Launer LJ, Witteman JC, den Breeijen JH, Breteler MM, Grobbee DE, Hofman A. Dietary antioxidants and cognitive function in a population-based sample of older persons: the Rotterdam Study. Am J Epidemiol. 1996;144:275-80.
11. Perrig WJ, Perrig P, Stä helin HB. The relation between antioxidants and memory performance in the old and very old. J Am Geriatr Soc. 1997; 45:718-24.
12. Joseph JA, Shukitt-Hale B, Denisova NA, Prior RL, Cao G, Martin A, Taglialatela G, Bickford PC. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci. 1998;18:8047-55.
13. Bandayrel K, Wong S. Systematic literature review of randomized control trials assessing the effectiveness of nutrition interventions in community-dwelling older adults. J Nutr Educ Behav. 2011;43: 251-62.
14. Jenab M, Salvini S, van Gils CH, Brustad M, Shakya-Shrestha S, Buijsse B, Verhagen H, Touvier M, Biessy C, et al. Dietary intakes of retinol, beta-carotene, vitamin D and vitamin E in the European Prospective Investigation into Cancer and Nutrition cohort. Eur J Clin Nutr. 2009;63(Suppl 4):S150-78.
15. Smith GD, Lawlor DA, Harbord R, Timpson N, Day I, Ebrahim S. Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med. 2007;4:e352.
16. Sheehan NA, Didelez V, Burton PR, Tobin MD. Mendelian randomisation and causal inference in observational epidemiology. PLoS Med. 2008;5:e177.
17. Halcyon.ac.uk [Homepage on the Internet]. HALCyon project [cited 2012 Dec 5]. Available from: http://www.halcyon.ac.uk/.
18. Njajou OT, Alizadeh BZ, Aulchenko Y, Zillikens MC, Pols HAP, Oostra BA, Swinkels DW, van Duijn CM. Heritability of serum iron, ferritin and transferrin saturation in a genetically isolated population, the Erasmus Rucphen Family (ERF) Study. Hum Hered. 2006;61:222-8.
19. Tanaka T, Roy CN, Yao W, Matteini A, Semba RD, Arking D, Walston JD, Fried LP, Singleton A, et al. A genome-wide association analysis of serum iron concentrations. Blood. 2010;115:94-6.
20. Pichler I, Minelli C, Sanna S, Tanaka T, Schwienbacher C, Naitza S, Porcu E, Pattaro C, Busonero F, et al. Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum Mol Genet. 2011;20:1232-40.
21. Benyamin B, Ferreira MAR, Willemsen G, Gordon S, Middelberg RPS, McEvoy BP, Hottenga s, Henders AK, Campbell MJ, et al. Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet. 2009;41:1173-5.
22. Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005;352:1769-78.
23. Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology. 2010;139:393-408, 408.e1-2.
24. Hazra A, Kraft P, Selhub J, Giovannucci EL, Thomas G, Hoover RN, Chanock SJ, Hunter DJ. Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat Genet. 2008;40:1160-2.
25. Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, D'Agostino RB Sr, Ordovas JM, O'Donnell CJ, Dawson-Hughes B, et al. Genetic and non-genetic correlates of vitamins K and D. Eur J Clin Nutr. 2009;63:458-64.
26. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010;376:180-8.
27. Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, Gallicchio L, Jacobs EJ, Ascherio A, Helzlsouer K, et al. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet. 2010;19:2739-45.
28. Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, et al. Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet. 2009;84:123-33.
29. Brown M, Dodgeon B. NCDS cognitive assessments at age 50: initial results. London: Centre for Longitudinal Studies. Working Paper 2010/1;2010.
30. Power C, Elliott J. Cohort profile: 1958 British birth cohort (National Child Development Study). Int J Epidemiol. 2006;35:34-41.
31. MRC National Survey for Health and Development [Homepage on the Internet] [cited 2012 Dec 5]. Available from: http://www.nshd.mrc.ac.uk/.
32. Wadsworth M, Kuh D, Richards M, Hardy R. Cohort profile: the 1946 National Birth Cohort (MRC National Survey of Health and Development). Int J Epidemiol. 2006;35:49-54.
33. Marmot M, Brunner E. Cohort profile: the Whitehall II study. Int J Epidemiol. 2005;34:251-6.
34. Bristol University, School of Social and Community Medicine. Caerphilly Prospective Study [cited 2012 Dec 5]. Available from: http://www.bris.ac.uk/social-community-medicine/projects/caerphilly/.
35. Marmot M, Banks J, Blundell R, Lessof C, Nazroo J, editors. Health, wealth and lifestyles of the older population in England: the 2002 English Longitudinal Study of Ageing. London: Institute for Fiscal Studies;2003.
36. The Lothian birth cohorts of 1921 and 1936 [cited 2012 Dec 5]. Available from: http://www.lothianbirthcohort.ed.ac.uk/.
37. Deary IJ, Whiteman MC, Starr JM, Whalley LJ, Fox HC. The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947. J Pers Soc Psychol. 2004;86:130-47.
38. Deary IJ, Gow AJ, Pattie A, Starr JM. Cohort profile: the Lothian birth cohorts of 1921 and 1936. Int J Epidemiol. 2012;41(6):1576-84.
39. LGC Genomics, KBioscience [Homepage on the Internet] [cited 2012 Dec 5]. Available from: http://www.lgcgenomics.com/.
40. Illumina, Inc. [Homepage on the Internet] [cited 2012 Dec 5] Available from: http://www.illumina.com/.
41. Houlihan LM, Davies G, Tenesa A, Harris SE, Luciano M, Gow AJ, McGhee KA, Liewald DC, Porteous DJ, Starr JM. Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time. Am J Hum Genet. 2010;86:626-31.
42. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661-78.
43. Richards M, Kuh D, Hardy R, Wadsworth M. Lifetime cognitive function and timing of the natural menopause. Neurology. 1999;53: 308-14.
44. Cordell HJ, Clayton DG. Genetic association studies. Lancet. 2005; 366:1121-31.
45. Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia- Naji N, Langenberg C, Prokopenko I, et al. Common variants at 10 genomic loci influence hemoglobin A1(C) levels via glycemic and nonglycemic pathways. Diabetes. 2010;59:3229-39.
46. Pankow JS, Boerwinkle E, Adams PC, Guallar E, Leiendecker-Foster C, Rogowski J, Eckfeldt JH. HFE C282Y homozygotes have reduced lowdensity lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study. Transl Res. 2008;152:3-10.
47. Riley RD, Lambert PC, Abo-Zaid G. Meta-analysis of individual participant data: rationale, conduct, and reporting. BMJ. 2010;340: c221.
48. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-60.
49. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000;283: 2008-12.
50. Little J, Higgins JPT, Ioannidis JPA, Moher D, Gagnon F, von Elm E, Khoury MJ, Cohen B, Davey-Smith G, et al.. Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. J Clin Epidemiol. 2009;62:597-608.e4.
51. Benyamin B, McRae AF, Zhu G, Gordon S, Henders AK, Palotie A, Peltonen L, Martin NG, Montgomery GW, et al. Variants in TF and HFE explain approximately 40% of genetic variation in serumtransferrin levels. Am J Hum Genet. 2009;84:60-5.
52. Schiepers OJG, van Boxtel MPJ, de Groot RHM, Jolles J, de Kort WLAM, Swinkels DW, Kok FJ, Verhoef P, Durga J. Serum iron parameters, HFE C282Y genotype, and cognitive performance in older adults: results from the FACIT study. J Gerontol A Biol Sci Med Sci. 2010;65:1312-21.
53. Wang FT, Hu H, Schwartz J, Weuve J, Spiro AS, Sparrow D, Nie H, Silverman EK, Weiss ST, Wright RO. Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline. Environ Health Perspect. 2007;115:1210-5.
54. Taylor EM, Crowe A, Morgan EH. Transferrin and iron uptake by the brain: effects of altered iron status. J Neurochem. 1991;57:1584-92.
55. Collingwood J, Dobson J. Mapping and characterization of iron compounds in Alzheimer's tissue. J Alzheimers Dis. 2006;10:215-22.
56. Sofic E, Riederer P, Heinsen H, Beckmann H, Reynolds GP, Hebenstreit G, Youdim MB. Increased iron (III) and total iron content in post mortem substantia nigra of Parkinsonian brain. J Neural Transm. 1988;74:199-205.
57. Atamna H, Killilea DW, Killilea AN, Ames BN. Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc Natl Acad Sci USA. 2002;99:14807-12.
58. Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr. 2000; 71:614S-20S.
59. Vogiatzoglou A, Refsum H, Johnston C, Smith SM, Bradley KM, de Jager C, Budge MM, Smith AD. Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology. 2008;71: 826-32.
60. Reiter RJ. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J. 1995;9:526-33.
61. Berry DJ, Vimaleswaran KS, Whittaker JC, Hingorani AD, Hyppö nen E. Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D. PLoS ONE. 2012;7:e37465.
62. van der Wielen RP, Lö wik MR, van den Berg H, de Groot LC, Haller J, Moreiras O, van Staveren WA. Serum vitamin D concentrations among elderly people in Europe. Lancet. 1995;346:207-10.
63. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297:842-57.
64. Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR Jr. Dietary supplements and mortality rate in older women: the Iowa Women's Health Study. Arch Intern Med. 2011;171:1625-33.