A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations

Gene

Volumn 521, Issue 2, 2013, Pages 282-286

  Lu, Dandan ^a   Chen, Lingling ^b   Shi, Xin ^a   Zhang, Xiaoting ^c   Ling, Xin ^d   Chen, Xiaojian ^b   Xie, Lixia ^a   Jiang, Lingling ^a   Ding, Lan ^a   He, Yan ^e   Zhang, Xingqi ^c  

^a SOOCHOW UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d First Hospital of Wujiang City   (China)

^e MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Alopecia areata; Genetic susceptibility; IL1A; Rs3783553

Indexed keywords

INTERLEUKIN 1ALPHA; LUCIFERASE; MICRORNA 122;

ADULT; ALOPECIA AREATA; ARTICLE; BASE PAIRING; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ENZYME ASSAY; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INDEL MUTATION; MAJOR CLINICAL STUDY; MALE; ONSET AGE; POPULATION RESEARCH; PRIORITY JOURNAL; RISK ASSESSMENT;

3' UNTRANSLATED REGIONS; ADOLESCENT; ADULT; ALOPECIA AREATA; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT; INFANT, NEWBORN; INTERLEUKIN-1ALPHA; MALE; MICRORNAS; MUTAGENESIS, INSERTIONAL; POLYMORPHISM, GENETIC; RISK; SEQUENCE DELETION; YOUNG ADULT;

EID: 84876969485     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.02.048     Document Type: Article

References (31)

1. Allen R.C., Graves G., Budowle B. Polymerase chain reaction amplification products separated on rehydratable polyacrylamide gels and stained with silver. Biotechniques 1989, 7:736-744.
2. Barahmani N., de Andrade M., Slusser J., Zhang Q., Duvic M. Interleukin-1 receptor antagonist allele 2 and familial alopecia areata. J. Invest. Dermatol. 2002, 118:335-337.
3. Barahmani N., et al. Human leukocyte antigen class II alleles are associated with risk of alopecia areata. J. Invest. Dermatol. 2008, 128:240-243.
4. Betz R.C., et al. The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata. Br. J. Dermatol. 2008, 158:389-391.
5. Entz P., et al. Investigation of the HLA-DRB1 locus in alopecia areata. Eur. J. Dermatol. 2006, 16:363-367.
6. Forstbauer L.M., et al. Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata. Eur. J. Hum. Genet. 2012, 20:326-332.
7. Gao Y., et al. An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma. Carcinogenesis 2009, 30:2064-2069.
8. Garg S., Messenger A.G. Alopecia areata: evidence-based treatments. Semin. Cutan. Med. Surg. 2009, 28:15-18.
9. Gilhar A., Kalish R.S. Alopecia areata: a tissue specific autoimmune disease of the hair follicle. Autoimmun. Rev. 2006, 5:64-69.
10. Gregoriou S., Papafragkaki D., Kontochristopoulos G., Rallis E., Kalogeromitros D., Rigopoulos D. Cytokines and other mediators in alopecia areata. Mediat. Inflamm. 2010, 2010:928030.
11. Hong S.B., Jin S.Y., Park H.J., Jung J.H., Sim W.Y. Analysis of the monocyte chemoattractant protein 1-2518 promoter polymorphism in Korean patients with alopecia areata. J. Korean Med. Sci. 2006, 21:90-94.
12. Jackow C., Puffer N., Hordinsky M., Nelson J., Tarrand J., Duvic M. Alopecia areata and cytomegalovirus infection in twins: genes versus environment?. J. Am. Acad. Dermatol. 1998, 38:418-425.
13. Jagielska D., et al. Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance. J. Invest. Dermatol. 2012, 132:2192-2197.
14. Lu W., et al. Alopecia areata: pathogenesis and potential for therapy. Expert Rev. Mol. Med. 2006, 8:1-19.
15. Manfè V., et al. miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma. PLoS One 2012, 7:e29541.
16. McDonagh A.J., Tazi-Ahnini R. Epidemiology and genetics of alopecia areata. Clin. Exp. Dermatol. 2002, 27:405-409.
17. Megiorni F., et al. Genetic association of HLA-DQB1 and HLA-DRB1 polymorphisms with alopecia areata in the Italian population. Br. J. Dermatol. 2011, 165:823-827.
18. Niessen F.B., Andriessen M.P., Schalkwijk J., Visser L., Timens W. Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars. J. Pathol. 2001, 194:207-216.
19. Olsen E., et al. Alopecia areata investigational assessment guidelines. National Alopecia Areata Foundation. J. Am. Acad. Dermatol. 1999, 40:242-246.
20. Olsen E.A., et al. Alopecia areata investigational assessment guidelines-Part II. National Alopecia Areata Foundation. J. Am. Acad. Dermatol. 2004, 51:440-447.
21. Petukhova L., et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 2010, 466:113-117.
22. Philpott M.P., Sanders D.A., Bowen J., Kealey T. Effects of interleukins, colony-stimulating factor and tumour necrosis factor on human hair follicle growth in vitro: a possible role for interleukin-1 and tumour necrosis factor-alpha in alopecia areata. Br. J. Dermatol. 1996, 135:942-948.
23. Rodriguez T.A., Fernandes K.E., Dresser K.L., Duvic M., National Alopecia Areata Registry Concordance rate of alopecia areata in identical twins supports both genetic and environmental factors. J. Am. Acad. Dermatol. 2010, 62:525-527.
24. Schwartz R.A., Janniger C.K. Alopecia areata. Cutis 1997, 59:238-341.
25. Tarlow J.K., et al. Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. J. Invest. Dermatol. 1994, 103:387-390.
26. Tazi-Ahnini R., et al. Association analysis of IL1A and IL1B variants in alopecia areata. Heredity 2001, 87:215-219.
27. Tazi-Ahnini R., et al. Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis. Tissue Antigens 2002, 60:489-495.
28. Teraki Y., Imanishi K., Shiohara T. Cytokines in alopecia areata: contrasting cytokine profiles in localized form and extensive form (alopecia universalis). Acta Derm. Venereol. 1996, 76:421-423.
29. Wasserman D., Guzman-Sanchez D.A., Scott K., McMichael A. Alopecia areata. Int. J. Dermatol. 2007, 46:121-131.
30. Xiao F.L., et al. Association of HLA-DQA1 and DQB1 alleles with alopecia areata in Chinese Hans. Arch. Dermatol. Res. 2005, 297:201-209.
31. Yang Z.H., Dai Q., Zhong L., Zhang X., Guo Q.X., Li S.N. Association of IL-1 polymorphisms and IL-1 serum levels with susceptibility to nasopharyngeal carcinoma. Mol. Carcinog. 2011, 50:208-214.