Cor a 1-reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen-associated food allergy to hazelnut

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 5, 2013, Pages

  Hofmann, Claudia ^a   Scheurer, Stephan ^b   Rost, Kathrin ^a   Graulich, Edith ^a   Jamin, Annette ^b   Foetisch, Kay ^b   Saloga, Joachim ^a   Vieths, Stefan ^b   Steinbrink, Kerstin ^a   Adler, Henric S ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b PAUL EHRLICH INSTITUT   (Germany)

Author keywords

Bet v 1; birch pollen allergy; carrot; Cor a 1; Dau c 1; food allergy; hazelnut; IgE; oral allergy syndrome; pathogenesis related proteins; T cell cross reactivity; type I allergy

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9;

ADULT; ARTICLE; BIRCH; CARROT; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; FOOD ALLERGY; HAZELNUT; HUMAN; IMMUNOTHERAPY; LYMPHOCYTE PROLIFERATION; MALE; POLLEN ALLERGY; PRIMARY CELL CULTURE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 84876947340     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.10.037     Document Type: Article

References (41)

1. B. Wuthrich, C. Schindler, P. Leuenberger, and U. Ackermann-Liebrich Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study). Swiss Study on Air Pollution and Lung Diseases in Adults Int Arch Allergy Immunol 106 1995 149 156
2. S. Vieths, S. Scheurer, and B. Ballmer-Weber Current understanding of cross-reactivity of food allergens and pollen Ann N Y Acad Sci 964 2002 47 68
3. R. van Ree Clinical importance of cross-reactivity in food allergy Curr Opin Allergy Clin Immunol 4 2004 235 240
4. M. Egger, S. Mutschlechner, N. Wopfner, G. Gadermaier, P. Briza, and F. Ferreira Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view Allergy 61 2006 461 476
5. C.H. Katelaris Food allergy and oral allergy or pollen-food syndrome Curr Opin Allergy Clin Immunol 10 2010 246 251
6. A. Mari, B.K. Ballmer-Weber, and S. Vieths The oral allergy syndrome: improved diagnostic and treatment methods Curr Opin Allergy Clin Immunol 5 2005 267 273
7. S. Ma, S.H. Sicherer, and A. Nowak-Wegrzyn A survey on the management of pollen-food allergy syndrome in allergy practices J Allergy Clin Immunol 112 2003 784 788
8. N.E. Eriksson, H. Formgren, and E. Svenonius Food hypersensitivity in patients with pollen allergy Allergy 37 1982 437 443
9. B. Bohle The impact of pollen-related food allergens on pollen allergy Allergy 62 2007 3 10
10. C. Ebner, R. Hirschwehr, L. Bauer, H. Breiteneder, R. Valenta, and H. Ebner Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin) J Allergy Clin Immunol 95 1995 962 969
11. L. Kazemi-Shirazi, G. Pauli, A. Purohit, S. Spitzauer, R. Froschl, and K. Hoffmann-Sommergruber Quantitative IgE inhibition experiments with purified recombinant allergens indicate pollen-derived allergens as the sensitizing agents responsible for many forms of plant food allergy J Allergy Clin Immunol 105 2000 116 125
12. E. Klinglmayr, M. Hauser, F. Zimmermann, O. Dissertori, P. Lackner, and N. Wopfner Identification of B-cell epitopes of Bet v 1 involved in cross-reactivity with food allergens Allergy 64 2009 647 651
13. M. Wensing, J.H. Akkerdaas, W.A. van Leeuwen, S.O. Stapel, C.A. Bruijnzeel-Koomen, and R.C. Aalberse IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance J Allergy Clin Immunol 110 2002 435 442
14. H. Breiteneder, and C. Ebner Molecular and biochemical classification of plant-derived food allergens J Allergy Clin Immunol 106 2000 27 36
15. R. Hirschwehr, R. Valenta, C. Ebner, F. Ferreira, W.R. Sperr, and P. Valent Identification of common allergenic structures in hazel pollen and hazelnuts: a possible explanation for sensitivity to hazelnuts in patients allergic to tree pollen J Allergy Clin Immunol 90 1992 927 936
16. K. Hoffmann-Sommergruber, G. O'Riordain, H. Ahorn, C. Ebner, M. Laimer Da Camara Machado, and H. Puhringer Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1 Clin Exp Allergy 29 1999 840 847
17. Z. Markovic-Housley, A. Basle, S. Padavattan, B. Maderegger, T. Schirmer, and K. Hoffmann-Sommergruber Structure of the major carrot allergen Dau c 1 Acta Crystallogr D Biol Crystallogr 65 2009 1206 1212
18. D. Luttkopf, U. Muller, P.S. Skov, B.K. Ballmer-Weber, B. Wuthrich, and K. Skamstrup Hansen Comparison of four variants of a major allergen in hazelnut (Corylus avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01 Mol Immunol 38 2002 515 525
19. B. Jahn-Schmid, A. Radakovics, D. Luttkopf, S. Scheurer, S. Vieths, and C. Ebner Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens J Allergy Clin Immunol 116 2005 213 219
20. R. Fritsch, B. Bohle, U. Vollmann, U. Wiedermann, B. Jahn-Schmid, and M. Krebitz Bet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, cross-react at the level of allergen-specific T helper cells J Allergy Clin Immunol 102 1998 679 686
21. B. Bohle, A. Radakovics, D. Luttkopf, B. Jahn-Schmid, S. Vieths, and C. Ebner Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens Clin Exp Allergy 35 2005 1392 1399
22. C. Ebner, F. Ferreira, K. Hoffmann, R. Hirschwehr, S. Schenk, and Z. Szepfalusi T cell clones specific for Bet v I, the major birch pollen allergen, crossreact with the major allergens of hazel, Cor a I, and alder, Aln g I Mol Immunol 30 1993 1323 1329
23. C. Ebner, S. Schenk, Z. Szepfalusi, K. Hoffmann, F. Ferreira, and M. Willheim Multiple T cell specificities for Bet v I, the major birch pollen allergen, within single individuals. Studies using specific T cell clones and overlapping peptides Eur J Immunol 23 1993 1523 1527
24. C. Ebner, Z. Szepfalusi, F. Ferreira, A. Jilek, R. Valenta, and P. Parronchi Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides J Immunol 150 1993 1047 1054
25. B. Bohle, A. Radakovics, B. Jahn-Schmid, K. Hoffmann-Sommergruber, G.F. Fischer, and C. Ebner Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level Eur J Immunol 33 2003 3303 3310
26. C.A. Akdis, and M. Akdis Mechanisms of allergen-specific immunotherapy J Allergy Clin Immunol 127 2011 18 29
27. S.T. Bolhaar, M.M. Tiemessen, L. Zuidmeer, A. van Leeuwen, K. Hoffmann-Sommergruber, and C.A. Bruijnzeel-Koomen Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges Clin Exp Allergy 34 2004 761 769
28. X. Bucher, W.J. Pichler, C.A. Dahinden, and A. Helbling Effect of tree pollen specific, subcutaneous immunotherapy on the oral allergy syndrome to apple and hazelnut Allergy 59 2004 1272 1276
29. K.S. Hansen, M.S. Khinchi, P.S. Skov, C. Bindslev-Jensen, L.K. Poulsen, and H.J. Malling Food allergy to apple and specific immunotherapy with birch pollen Mol Nutr Food Res 48 2004 441 448
30. T. Kinaciyan, B. Jahn-Schmid, A. Radakovics, B. Zwolfer, C. Schreiber, and J.N. Francis Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1 J Allergy Clin Immunol 119 2007 937 943
31. D. Mittag, V. Batori, P. Neudecker, R. Wiche, E.P. Friis, and B.K. Ballmer-Weber A novel approach for investigation of specific and cross-reactive IgE epitopes on Bet v 1 and homologous food allergens in individual patients Mol Immunol 43 2006 268 278
32. H. Weigt, P.F. Muhlradt, M. Larbig, N. Krug, and A. Braun The Toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model J Immunol 172 2004 6080 6086
33. I. Bellinghausen, U. Brand, J. Knop, and J. Saloga Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors J Allergy Clin Immunol 105 2000 988 996
34. T. Takishita, M. Okano, K. Takahashi, T. Yoshino, Y. Sugata, and H. Hattori Characterization of allergen-specific monocyte-derived dendritic cells generated from monocytes by a single-step procedure: effect on naive and memory T cells Allergy 60 2005 211 217
35. H. Hammad, A.S. Charbonnier, C. Duez, A. Jacquet, G.A. Stewart, and A.B. Tonnel Th2 polarization by Der p 1-pulsed monocyte-derived dendritic cells is due to the allergic status of the donors Blood 98 2001 1135 1141
36. U. Smole, S. Wagner, N. Balazs, C. Radauer, M. Bublin, and G. Allmaier Bet v 1 and its homologous food allergen Api g 1 stimulate dendritic cells from birch pollen-allergic individuals to induce different Th-cell polarization Allergy 65 2010 1388 1396
37. U. Smole, N. Balazs, K. Hoffmann-Sommergruber, C. Radauer, C. Hafner, and M. Wallner Differential T-cell responses and allergen uptake after exposure of dendritic cells to the birch pollen allergens Bet v 1.0101, Bet v 1.0401 and Bet v 1.1001 Immunobiology 215 2010 903 909
38. I. Lauer, S. Alessandri, S. Pokoj, A. Reuter, A. Conti, and S. Vieths Expression and characterization of three important panallergens from hazelnut Mol Nutr Food Res 52 suppl 2 2008 S262 S271
39. H.S. Adler, A. Simon, E. Graulich, A. Habermeier, N. Bacher, and A. Friebe Neuronal nitric oxide synthase modulates maturation of human dendritic cells J Immunol 184 2010 6025 6034
40. A. Marknell DeWitt, V. Niederberger, P. Lehtonen, S. Spitzauer, W.R. Sperr, and P. Valent Molecular and immunological characterization of a novel timothy grass (Phleum pratense) pollen allergen, Phl p 11 Clin Exp Allergy 32 2002 1329 1340
41. P.G. Gottschalk, and J.R. Dunn Measuring parallelism, linearity, and relative potency in bioassay and immunoassay data J Biopharm Stat 15 2005 437 463