Quantitative IgE inhibition experiments with purified recombinant allergens indicate pollen-derived allergens as the sensitizing agents responsible for many forms of plant food allergy

Journal of Allergy and Clinical Immunology

Volumn 105, Issue 1 I, 2000, Pages 116-125

  Kazemi Shirazi, Lili ^a   Pauli, Gabrielle ^b   Purohit, Ashok ^b   Spitzauer, Susanne ^a   Fröschl, Renate ^a   Hoffmann Sommergruber, Karin ^a   Breiteneder, Heimo ^a   Scheiner, Otto ^a   Kraft, Dietrich ^a   Valenta, Rudolf ^a,c  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cross reactivity; Food allergy; Pollen allergy; Recombinant allergens

Indexed keywords

IMMUNOGLOBULIN E; POLLEN ANTIGEN;

ADULT; ANTIGEN RECOGNITION; ARTICLE; CROSS REACTION; DESENSITIZATION; FEMALE; FOOD ALLERGY; HUMAN; IMMUNOBLOTTING; IMMUNOGENICITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 6444245549     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(00)90186-6     Document Type: Article

References (42)

1. Bruijnzeel-Koomen C, Ortolani C, Aas K, Bindslev-Jensen C, Björksten B, Moneret-Vautrin D, et al. Adverse reactions to food. Allergy 1995;50:623-35.
2. Altmann DR, Chiaramonte LT. Public perception of food allergy. J Allergy Clin Immunol 1996:97:1247-51.
3. Eriksson NE, Formgren H, Svenonius E. Food hypersensitivity in patients with pollen allergy. Allergy 1982;37:437-43.
4. Etesamifar M, Wüthrich B. IgE-medialed food allergies including oral allergy syndrome in 383 patients. Allergologie 1998;21:451-7.
5. Pauli G, Bessot J, Dietemann-Molard A, Braun PA, Thierry R. Celery sensitivity: clinical and immunological correlations with pollen allergy. Clin Allergy 1985;15:273-9.
6. Ortolani C, Ispano M, Pastorello E, Bigi A, Ansaloni R. The oral allergy syndrome. Ann Allergy 1988;61:47-52.
7. Andersen KE, Løwenstein H. An investigation of the possible immunological relationship between allergen extracts from birch pollen, hazelnut, potato and apple. Contact Dermatitis 1978;4:73-9.
8. Lahti A, Björksten F, Hannuksela M. Allergy to birch pollen and apple, and cross-reactivity of the allergens studied with the RAST. Allergy 1980;35:297-300.
9. Aalberse RC, Koshte V, Clemens JG. Immunoglobulin E antibodies that cross-react with vegetable foods, pollen, and Hymenoptera venom. J Allergy Clin Immunol 1981;68:356-64.
10. Halempuro L, Løwenstein H. Immunological investigation of possible structural similarities between pollen antigens and antigens in apple, carrot and celery tuber. Allergy 1985;40:264-72.
11. Calkhoven PG, Aalbers M, Koshte VL, Pos O, Oei HD, Aalberse RC. Cross-reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross-reactive structures. Allergy 1987;42:382-90.
12. Ortolani C, Ispano M, Pastorello EA, Ausaloni R, Margi GC. Comparison of results of skin prick tests (with fresh foods and commercial food extracts) and RAST in 100 patients with oral allergy syndrome. J Allergy Clin Immunol 1989;83:683-90.
13. Asero R, Massironi F. Velati C. Detection of prognostic factors for oral allergy syndrome in patients with birch pollen hypersensitivity. J Allergy Clin Immunol 1996;97:611-6.
14. Ebner C, Birkner T, Valenta R, Rumpold H, Breitenbach M, Scheiner O, et al. Common epitopes of birch pollen and apples- studies by Western and Northern blot. J Allergy Clin Immunol 1991;88:588-94.
15. Hirschwehr R, Valenta R, Ebner C, Ferreira F, Sperr WR, Valent P, et al. Identification of common allergenic structures in hazel pollen and hazelnuts: a possible explanation for sensitivity to hazelnuts in patients allergic to tree pollen. J Allergy Clin Immunol 1992;90:927-36.
16. Vallier P, DeChamp C, Valenta R, Vial O. Deviller P. Purification and characterization of an allergen from celery immunochemically related to an allergen present in several other plant species. Identification as profilin. Clin Exp Allergy 1992;22:774-82.
17. van Ree, Voitenko V, van-Leeuwen WA, Aalberse RC. Profilin is a cross-reactive allergen in pollen and vegetable foods, Int Arch Allergy Immunol 1992;98:97-104.
18. Ebner C, Hirschwehr R, Bauer L, Breiteneder H, Valenta R, Ebner H. et al. Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). J Allergy Clin Immunol 1995;95:962-9.
19. Heiss S. Fischer S. Müller W-D, Weber B, Hirschwehr R, Spitzauer S, et al. Identification of a 60 kd cross-reactive allergen in pollen and plant-derived food. J Allergy Clin Immunol 1996;98:938-47.
20. Vanek-Krebitz M. Hoffmann-Sommergruber K, Laimer-da-Camara-Machado M, Susani M, Ebner C, Kraft D. et al. Cloning and sequencing of Mal d 1. the major allergen from apple (Malus domestica) and its immunological relationship to Bet v 1, the major birch pollen allergen. Biochem Biophys Res Commun 1995;214:538-51.
21. Breiteneder H, Hoffmann-Sommergruber K, O'Riordain G. Susani M, Ahorn H, Ebner C, et al. Molecular characterization of Api g 1, the major allergen of celery (Apium graveolens), and its immunological and structural relationships to a group of 17-kDa tree pollen allergens. Eur J Biochem 1995;233:484-9.
22. Hoffmann-Sommergruber K, O'Riordain G, Ahorn H, Ebner C, Laimer Da Camera Machado M, Pühringer H, et al. Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1. Clin Exp Allergy 1999;29:840-7.
23. Fritsch R. Bohle B, Vollmann U, Wiedermann U. Jahn-Schmid B. Krebitz M, et al. Bet v 1, the major birch pollen allergen, and Mal d 1. the major apple allergen. cross-react at the level of allergen-specific T helper cells. J Allergy Clin Immunol 1998;102:679-86.
24. Werfel T, Reekers R, Busche M, Schmidt P. Constien A, Wittmann M, et al. Evidence for a birch pollen-specific cutaneous T-cell response in food-responsive atopic dermatitis. Int Arch Allergy Immunol 1999;118:230-1.
25. Ferreira FD, Mayer P, Sperr WR, Valent P, Seiberler S, Ebner C, et al. Induction of IgE antibodies with predefined specificity in rhesus monkeys with recombinant birch pollen allergens, Bet v 1 and Bet v 2. J Allergy Clin Immunol 1996;97:95-103.
26. Fernandez-Rivas M. van Ree, Cuevas M. Allergy to Rosaceae fruits without related pollinosis. J Allergy Clin Immunol 1997;100:728-33.
27. Valenta R, Kraft D. Type 1 allergic reactions to plant-derived food: A consequence of primary sensitization to pollen allergens. J Allergy Clin Immunol 1996;97:893-5.
28. Royal College of Physicians and Royal College of Pathologists. Good allergy practice-Standards of care for providers and purchasers of allergy services within the National Health Service. Clin Exp Allergy 1995;25:586-95.
29. Niederberger V, Laffer S, Fröschl R. Kraft D. Rumpold H. Kapiotis S, et al. IgE antibodies to recombinant pollen allergens (Phl p 1. Phl p 2, Phl p 5, and Bet v 2) account for a high percentage of grass-specific IgE. J Allergy Clin Immunol 1998;101:258-64.
30. Niederberger V, Pauli G, Grönlund H, Fröschl R, Rumpold H, Kraft D, et al. Recombinant birch pollen allergens (rBet v 1, rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. J Allergy Clin Immunol 1998;102:579-91.
31. Vrtala S, Grote M. Duchene M. van Ree R, Kraft D. Scheiner O, et al. Properties of tree and grass pollen allergens: reinvestigation of the linkage between solubility and allergenicity. Int Arch Allergy Immunol 1993;102:160-9.
32. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
33. Fling SP, Gregerson DS. Peptide and protein molecular weight determination by electrophoresis using a high-molarity tris buffer system without urea. Anal Biochem 1986;155:83-8.
34. Bradford MM. A rapid and sensitive method for the quantitation of microgramm quantities of protein utilizing the principle of protein-dye-binding. Anal Biochem 1976;72:248-54.
35. Breiteneder H, Pettenburger K. Bito A, Valenta R, Kraft D, Rumpold H, et al. The gene coding for the major birch pollen allergen. Bet v 1, is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-8.
36. Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P. et al. Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 1991;253:557-60.
37. Towbin H, Staehelin T, Gordon T. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4.
38. Bircher AJ, van Melle, Haller E, Curty B, Frei PC. IgE to food allergens are highly prevalent in patients allergic to pollens, with and without symptoms of food allergy. Clin Exp Allergy 1993;24:367-74.
39. Pastorello EA, Conti A. Pravettoni V. Farioli L, Rivolta F. Ansaloni R, et al. Identification of actinidin as the major allergen of kiwi fruit. J Allergy Clin Immunol 1998;101:531-7.
40. Durham SR. Gould HJ. Thienes CP, Jacobson MR, Masuyama K, Rak S, et al. Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. Eur J Immunol 1997;27:2899-906.
41. Atkins FM, Steinberg SS, Metcalfe DD. Evaluation of immediate adverse reactions to foods in adult patients. I. Correlation of demographic, laboratory, and prick skin test data with response to controlled oral food challenge. J Allergy Clin Immunol 1985;75:348-55.
42. Bischoff SC, Mayer J, Wedemayer J, Meier PN, Zeck-Kapp G, Wedi B, et al. Colonoscopic allergen provocation (COLAP): a new diagnostic approach for gastrointestinal food allergy. Gut 1997;40:745-53.