CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells

Cancer Research

Volumn 73, Issue 8, 2013, Pages 2563-2573

  Jacobs, Elizabeth T ^a,b   Van Pelt, Chad ^c   Forster, Ryan E ^d   Zaidi, Wasiq ^c   Hibler, Elizabeth A ^a,b   Galligan, Michael A ^c   Haussler, Mark R ^d   Jurutka, Peter W ^c,d  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYP24A1; CYP27B1; CYTOCHROME P450; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; CYP24A1 GENE; CYP27B1 GENE; ENZYME ACTIVITY; ENZYME MECHANISM; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; HEREDITY; HUMAN; HUMAN CELL; METABOLITE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; TUMOR GENE; VITAMIN D METABOLISM;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; CELL LINE, TUMOR; COLONIC NEOPLASMS; ENZYME ACTIVATION; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; STEROID HYDROXYLASES; TRANSCRIPTION, GENETIC; VITAMIN D;

EID: 84876941701     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-4134     Document Type: Article

References (32)

1. Zhang X, Giovannucci E. Calcium, vitamin D and colorectal cancer chemoprevention. Best Pract Res Clin Gastroenterol 2011;25:485-94.
2. Haussler MR, Haussler CA, Whitfield GK, Hsieh J-C, Thompson PD, Barthel TK, et al. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging. J Steroid Biochem Mol Biol 2010;121:88-97.
3. Fleet JC, DeSmet M, Johnson R, Li Y. VitaminDand cancer: A reviewof molecular mechanisms. Biochem J 2012;441:61-76.
4. Peehl DM, Skowronski RJ, Leung GK, Wong ST, Stamey TA, Feldman D. Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells. Cancer Res 1994;54: 805-10.
5. Frampton RJ, Omond SA, Eisman JA. Inhibition of human cancer cell growth by 1,25-dihydroxyvitamin D3 metabolites. Cancer Res 1983; 43:4443-7.
6. Giuliano AR, Franceschi RT, Wood RJ. Characterization of the vitamin D receptor from the Caco-2 human colon carcinoma cell line: Effect of cellular differentiation. Arch Biochem Biophys 1991;285:261-9.
7. Shabahang M, Buras RR, Davoodi F, Schumaker LM, Nauta RJ, Evans SR. 1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition. Cancer Res 1993;53:3712-8.
8. Cross HS, Bareis P, Hofer H, Bischof MG, Bajna E, Kriwanek S, et al. 25-Hydroxyvitamin D(3)-1alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids 2001;66:287-92.
9. Jones G, Prosser DE, Kaufmann M. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Arch Biochem Biophys 2012;523:9-18.
10. McGrath JJ, Saha S, Burne TH, Eyles DW. A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol 2010;121:471-7.
11. Dong LM, Ulrich CM, Hsu L, Duggan DJ, Benitez DS, White E, et al. Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk. Cancer Epidemiol Biomarkers Prev 2009;18:2540-8.
12. McCullough ML, Bostick RM, Mayo TL. Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer. Ann Rev Nutr 2009;29:111-32.
13. Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, Freedman ND, et al. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis 2009;30:769-76.
14. Bartik L, Whitfield GK, Kaczmarska M, Lowmiller CL, Moffet EW, Furmick JK, et al. Curcumin: A novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem 2010;21:1153-61.
15. Meunier B, de Visser SP, Shaik S. Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes. Chem Rev 2004;104: 3947-80.
16. Kolek OI, Hines ER, Jones MD, LeSeuer LK, Lipko MA, Kiela PR, et al. 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: The final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol 2005;289:G1036-42.
17. Cross HS, Nittke T, Kallay E. Colonic vitamin D metabolism: Implications for the pathogenesis of inflammatory bowel disease and colorectal cancer. Mol Cell Endocrinol 2011;347:70-9.
18. Bises G, Kallay E, Weiland T, Wrba F, Wenzl E, Bonner E, et al. 25-hydroxyvitamin D3-1alpha-hydroxylase expression in normal and malignant human colon. J Histochem Cytochem 2004;52:985-9.
19. Signorello LB, Shi J, Cai Q, Zheng W, Williams SM, Long J, et al. Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. PLoS One 2011;6: E28623.
20. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, et al. Common genetic determinants of vitamin D insufficiency: A genome-wide association study. Lancet 2010;376:180-8.
21. Lechner D, Kallay E, Cross HS. 1alpha,25-dihydroxyvitamin D3 downregulates CYP27B1 and induces CYP24A1 in colon cells. Mol Cell Endocrinol 2007;263:55-64.
22. Kitanaka S, Takeyama K, Murayama A, Sato T, Okumura K, Nogami M. Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets. New Eng J Med 1998;338:653-61.
23. Sawada N, Sakaki T, Kitanaka S, Takeyama K, Kato S, Inouye K. Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli. Eur J Biochem/FEBS 1999;265:950-6.
24. Database of Single Nucleotide Polymorphisms (dbSNP). dbSNP accession, dbSNP Build 137 for human, 2012 [cited 2012 Aug 31]; Available from: Available from: Http://www.ncbi.nlm.nih.gov/SNP/
25. Wang LL, Li Y, Zhou SF. A bioinformatics approach for the phenotype prediction of nonsynonymous single nucleotide polymorphisms in human cytochromes P450. Drug Metab Dispos 2009;37:977-91.
26. Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, Wagenknecht LE, et al. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab 2008;93:3381-8.
27. Jacobs ET, Martinez ME, Jurutka PW. Vitamin D: Marker or mechanism of action? Cancer Epidemiol Biomarkers Prev 2011;20:585-90.
28. Schlingmann KP, Kaufmann M,Weber S, Irwin A, Goos C, John U, et al. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med 2011;365:410-21.
29. Harris SS, Dawson-Hughes B. Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women. Am J Clin Nutr 1998;67:1232-6.
30. Doherty TM, Tang W, Dascalos S, Watson KE, Demer LL, Shavelle RM, et al. Ethnic origin and serum levels of 1alpha,25-dihydroxyvitamin D3 are independent predictors of coronary calcium mass measured by electron-beam computed tomography. Circulation 1997;96:1477-81.
31. St-Arnaud R, Naja RP. Vitamin D metabolism, cartilage and bone fracture repair. Mol. Cell Endocrinol 2011;347:48-54.
32. Luo W, Hershberger PA, Trump DL, Johnson CS. 24-Hydroxylase in cancer: Impact on vitamin D-based anticancer therapeutics. J Steroid Biochem Mol Biol. Epub 2012 Oct 8.