Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model

Transplantation Proceedings

Volumn 45, Issue 3, 2013, Pages 1142-1148

  Lopes, P ^a   Fuhrmann, A ^a   Sereno, J ^d   Pereira, M J ^a,b,c   Nunes, P ^a   Pedro, J ^a   Melao A ^a   Reis, F ^d   Carvalho, E ^a,e  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UNIVERSITY OF ALGARVE   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e Portuguese Diabetes Association   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; CHOLESTEROL; CYCLOSPORIN; CYCLOSPORIN A; GLUCOSE; INSULIN; RAPAMYCIN; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG UPTAKE; EPIDIDYMIS; EPIDIDYMIS FAT; EX VIVO STUDY; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOCYTES; ANIMALS; CYCLOSPORINE; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; MODELS, ANIMAL; RATS; RATS, WISTAR; SIROLIMUS;

EID: 84876870991     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2013.02.009     Document Type: Conference Paper

References (35)

1. O. Heisel, R. Heisel, R. Balshaw New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and meta-analysis Am J Transplant 4 2004
2. F. Vincenti, S. Friman, E. Scheuermann Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus Am J Transplant 7 6 2007 1506 1514 (Pubitemid 46776239)
3. L.A. Øzbay, K. Smidt, D.M. Mortensen et al. Calcineurin inhibitors acutely improve insulin sensitivity without affecting insulin secretion in healthy human volunteers Br J Clin Pharmacol 73 4 2012 536 545
4. F.G. Cosio, T.E. Pesavento, S. Kim Patient survival after renal transplantation: IV. Impact of post-transplant diabetes Kidney Int 62 4 2002 1440 1446
5. F.G. Cosio, Y. Kudva, M. Van der Velde New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation Kidney Int 67 6 2005 2415 2421 (Pubitemid 41623405)
6. M.M. Sarwal, P.D. Yorgin, S. Alexander Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantation Transplantation 72 1 2001 13 21 (Pubitemid 32652500)
7. J.M. Smith, T.L. Nemeth, R.A. McDonald Current immunosuppressive agents: efficacy, side effects, and utilization Pediatr Clin North Am 50 6 2003 1283 1300 (Pubitemid 37549388)
8. L.A. Øzbay, K. Smidt, D.M. Mortensen Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells Br J Pharmacol 162 2011 136 146
9. A. Mota Sirolimus: a new option in transplantation Expert Opin Pharmacother 6 3 2005 479 487 (Pubitemid 40521084)
10. M. Rosner, M. Hengstschläger Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1 Hum Mol Genet 17 19 2008 2934 2948
11. R.J. Dowling, I. Topisirovic, B.D. Fonseca Dissecting the role of mTOR: lessons from mTOR inhibitors Biochim Biophys Acta 1804 3 2010 433 439
12. M.J. Pereira, J. Palming, M. Rizell mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes Mol Cell Endocrinol 355 2012 96 105
13. J.E. Kay, C.R. Benzie, M.R. Goodier Inhibition of T-lymphocyte activation by the immunosuppressive drug FK-506 Immunology 67 4 1989 473 477 (Pubitemid 19203683)
14. Y. Gueguen, L. Ferrari, M. Souidi Compared effect of immunosuppressive drugs cyclosporine A and rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG-CoA reductase Basic Clin Pharmacol Toxicol 100 6 2007 392 397 (Pubitemid 46778677)
15. N.S. Cutler, J. Heitman, M.E. Cardenas TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals Mol Cell Endocrinol 155 1-2 1999 135 142 (Pubitemid 29460972)
16. P. Cravedi, P. Ruggenenti, G. Remuzzi Sirolimus for calcineurin inhibitors in organ transplantation: contra Kidney Int 78 11 2010 1068 1074
17. S. Badiou, J.P. Cristol, G. Mourad Dyslipidemia following kidney transplantation: diagnosis and treatment Curr Diab Rep 9 4 2009 305 311
18. E. Carvalho, K. Kotani, O. Peroni Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle Am J Physiol Endocrinol Metab 289 4 2005 E551 E561
19. A. Mari, G. Pacini, E. Murphy A model-based method for assessing insulin sensitivity from the oral glucose tolerance test Diabetes Care 24 2001 539 548 (Pubitemid 32198427)
20. A. Kashiwagi, M.A. Verso, J. Andrews In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus J Clin Invest 72 1983 1246 1254 (Pubitemid 13013757)
21. Z.W. Yu, P.A. Jansson, B.L. Posner Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation Diabetologia 40 10 1997 1197 1203
22. D.L. Sigalet, N.M. Kneteman, I. Simpson Intestinal permeability after small intestinal transplantation and cyclosporine treatment Transplant Proc 24 3 1992 1120 1121
23. A.E. Böhmer, D.G. Souza, G. Hansel Long-term cyclosporine treatment in non- transplanted rats and metabolic risk factors of vascular diseases Chem Biol Interact 185 1 2010 53 58
24. V.P. Houde, S. Brûlé, W.T. Festuccia Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue Diabetes 59 6 2010 1338 1348
25. N.S. Cutler, X. Pan, J. Heitman The TOR signal transduction cascade controls cellular differentiation in response to nutrients Mol Biol Cell 12 12 2001 4103 4113 (Pubitemid 34001095)
26. G.R. Chang, Y.Y. Wu, Y.S. Chiu Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HIJ mice Basic Clin Pharmacol Toxicol 105 3 2009 188 198
27. J.L. Larsen, R.G. Bennett, T. Burkman et al. Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats Transplantation 82 4 2006 466 470 (Pubitemid 44290251)
28. N.D. Vaziri, K. Liang, H. Azad Effect of cyclosporine on HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, HDL receptor, VLDL receptor, and lipoprotein lipase expressions J Pharmacol Exp Ther 294 2 2000 778 783 (Pubitemid 30490857)
29. A. Espino, J. Lopez-Miranda, J. Blanco-Cerrada The effect of cyclosporine and methylprednisolone on plasma lipoprotein levels in rats J Lab Clin Med 125 2 1995 222 227
30. M. Pereira, J. Palming, M. Rizell et al. The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibits lipogenesis and alter expression of genes involved in lipid metabolism in human adipocytes Mol Cell Endocrinol 365 2 2013 260 269
31. B.D. Kahan, J. Podbielski, K.L. Napoli Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation Transplantation 66 8 1998 1040 1046 (Pubitemid 28513384)
32. A. MacDonald, J. Scarola, J.T. Burke Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus Clin Ther 22 suppl B 2000 B101 B121
33. N. Deblon, L. Bourgoin, C. Veyrat-Durebex Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats Br J Pharmacol 165 7 2012 2325 2340
34. J.B. Redmon, L.K. Olson, M.B. Armstrong Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells J Clin Invest 98 12 1996 2786 2793 (Pubitemid 26427406)
35. Y. Uchizono, M. Iwase, U. Nakamura Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling Endocrinology 145 5 2004 2264 2272 (Pubitemid 38535055)