Damage to the ventromedial prefrontal cortex reduces interpersonal disgust

Social Cognitive and Affective Neuroscience

Volumn 8, Issue 2, 2013, Pages 171-180

  Ciaramelli, Elisa ^a   Sperotto, Rebecca G ^a   Mattioli, Flavia ^b   di Pellegrino, Giuseppe ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Spedali Riuniti   (Italy)

Author keywords

Disgust; Emotions; Prefrontal cortex; Social cognition

Indexed keywords

AGED; ARTICLE; COMPARATIVE STUDY; EMOTION; FEMALE; HUMAN; HUMAN RELATION; MALE; MIDDLE AGED; MORALITY; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PATHOPHYSIOLOGY; PERCEPTION; PHYSIOLOGY; PREFRONTAL CORTEX;

AGED; EMOTIONS; FEMALE; HUMANS; INTERPERSONAL RELATIONS; MALE; MIDDLE AGED; MORALS; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; SOCIAL PERCEPTION;

EID: 84876858116     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nss087     Document Type: Article

References (58)

1. Amodio, D.M., Frith, C.D. (2006). Meeting of minds: the medial frontal cortex and social cognition. Nature Reviews Neuroscience, 7, 268-77.
2. Assmus, A., Giessing, C., Weiss, P.H., Fink, G.R. (2007). Functional interactions during the retrieval of conceptual action knowledge: an fMRI study. Journal of Cognitive Neuroscience, 19, 1004-12.
3. Beer, J.S., Heerey, E.A., Keltner, D., Scabini, D., Knight, R.T. (2003). The regulatory function of self-conscious emotion: insights from patients with orbitofrontal damage. Journal of Personality and Social Psychology, 85, 594-604.
4. Behrens, T.E., Hunt, L.T., Rushworth, M.F. (2009). The computation of social behavior. Science, 324, 1160-4.
5. Blair, R.J.R., Cipolotti, L. (2000). Impaired social response reversal: a case of 'acquired sociopathy'. Brain, 123, 1122-41.
6. Blumer, D., Benson, D. (1975). Personality changes with frontal and temporal lesions. In: Benson, D.F., Blumer, F., editors. Psychiatric Aspects of Neurologic Disease. New York: Grune & Stratton.
7. Buckner, R.L., Carroll, D.C. (2007). Self-projection and the brain. Trends in Cognitive Sciences, 11, 49-57.
8. Calder, A.J., Keane, J., Manes, F., Antoun, N., Young, A.W. (2000). Impaired recognition and experience of disgust following brain injury. Nature Neuroscience, 3, 1077-8.
9. Chapman, H.A., Kim, D.A., Susskind, J.M., Anderson, A.K. (2009). In bad taste: evidence for the oral origins of moral disgust. Science, 323, 1222-6.
10. Ciaramelli, E., Braghittoni, D., di Pellegrino, G. (2012). It is the outcome that counts! Damage to the ventromedial prefrontal cortex disrupts the integration of outcome and belief information for moral judgment. Journal of the International Neuropsychological Society, 18, 962-71.
11. Ciaramelli, E., Muccioli, M., Làdavas, E., di Pellegrino, G. (2007). Selective deficit in personal moral judgment following damage to ventromedial prefrontal cortex. Social Cognitive and Affective Neuroscience, 2, 84-92.
12. Deaner, R.O., Khera, A.V., Platt, M.L. (2005). Monkeys pay per view: adaptive valuation of social images by rhesus macaques. Current Biology, 15, 543-8.
13. Eslinger, P.J., Damasio, A.R. (1985). Severe disturbance of higher cognition after bilateral frontal lobe ablation. Patient EVR. Neurology, 35, 1731-41.
14. Folstein, M.F., Robins, L.N., Helzer, J.E. (1983). The Mini-Mental State Examination. Archives of General Psychiatry, 40, 812.
15. Greene, J.D., Sommerville, R.B., Nystrom, L.E., Darley, J.M., Cohen, J.D. (2001). An fMRI investigation of emotional engagement in moral judgment. Science, 293, 2105-8.
16. Harris, L.T., Fiske, S.T. (2006). Dehumanizing the lowest of the low: neuroimaging responses to extreme outgroups. Psychological Science, 17, 847-53.
17. Harris, L.T., Fiske, S.T. (2007). Social groups that elicit disgust are differentially processed in mPFC. Social Cognitive and Affective Neuroscience, 2, 45-51.
18. Harris, L.T., McClure, S.M., van den Bos, W., Cohen, J.D., Fiske, S.T. (2007). Regions of the MPFC differentially tuned to social and nonsocial affective evaluation. Cognitive, Affective & Behavioural Neuroscience, 7, 309-16.
19. Hodson, G., Costello, K. (2007). Interpersonal disgust, ideological orientations, and dehumanization as predictors of intergroup attitudes. Psychological Science, 18, 691-8.
20. Inbar, Y., Pizarro, D.A., Knobe, J., Bloom, P. (2009). Disgust sensitivity predicts intuitive disapproval of gays. Emotion, 9, 435-9.
21. International Committee of Medical Journal Editors. (1991). Statements from the Vancouver group. British Medical Journal, 302, 1194.
22. Kelley, W.M., Macrae, C.N., Wyland, C.L., Caglar, S., Inati, S., Heatherton, T.F. (2002). Finding the self? An event-related fMRI study. Journal of Cognitive Neuroscience, 14, 785-94.
23. Koenigs, M., Young, L., Adolphs, R., et al. (2007). Damage to the prefrontal cortex increases utilitarian moral judgments. Nature, 446, 908-11.
24. Krienen, F.M., Tu, P.C., Buckner, R.L. (2010). Clan mentality: evidence that the medial prefrontal cortex responds to close others. Journal of Neuroscience, 30, 13906-15.
25. Leland, J.W., Grafman, J. (2005). Experimental tests of the somatic marker hypothesis. Games and Economic Behavior, 52, 386-409.
26. Lewis, P.A., Rezaie, R., Brown, R., Roberts, N., Dunbar, R.I. (2011). Ventromedial prefrontal volume predicts understanding of others and social network size. Neuroimage, 15, 1624-9.
27. Liberman, N., Trope, Y. (2008). The psychology of transcending the here and now. Science, 322, 1201-5.
28. Macrae, C.N., Moran, J.M., Heatherton, T.F., Banfield, J.F., Kelley, W.M. (2004). Medial prefrontal activity predicts memory for self. Cerebral Cortex, 14, 647-54.
29. Marzillier, S., Davey, G. (2004). The emotional profiling of disgust-eliciting stimuli: evidence for primary and complex disgusts. Cognition and Emotion, 18, 313-36.
30. Mitchell, J.P., Macrae, C.N., Banaji, M.R. (2006). Dissociable medial prefrontal contributions to judgments of similar and dissimilar others. Neuron, 50, 655-63.
31. Mobbs, D., Yu, R., Meyer, M., et al. (2009). A key role for similarity in vicarious reward. Science, 324, 900.
32. Moll, J., de Oliveira-Souza, R., Moll, F.T., et al. (2005). The moral affiliations of disgust: A functional MRI study. Cognitive and Behavioral Neurology, 18, 68-78.
33. Moll, J., Schulkin, J. (2009). Social attachment and aversion in human moral cognition. Neuroscience and Biobehavioral Reviews, 33, 456-65.
34. Moran, J.M., Macrae, C.N., Heatherton, T.F., Wyland, C.L., Kelley, W.M. (2006). Neuroanatomical evidence for distinct cognitive and affective components of self. Journal of Cognitive Neuroscience, 18, 1586-94.
35. Moretti, L., di Pellegrino, G. (2010). Disgust selectively modulates reciprocal fairness in economic interactions. Emotion, 10, 169-80.
36. Noonan, M.P., Sallet, J., Rudebeck, P.H., Buckley, M.J., Rushworth, M.F. (2010). Does the medial orbitofrontal cortex have a role in social valuation? European Journal of Neuroscience, 31, 2341-51.
37. Oaten, M., Stevenson, R.J., Case, T.I. (2009). Disgust as a disease-avoidance mechanism. Psychological Bulletin, 135, 303-21.
38. O'Doherty, J.P. (2004). Reward representations and reward-related learning in the human brain: insights from neuroimaging. Current Opinion in Neurobiology, 14, 769-76.
39. Olatunji, B.O., Haidt, J., McKay, D., David, B. (2008). Core, animal-reminder, and contamination disgust: three kinds of disgust with distinct personality, behavioral, physiological, and clinical correlates. Journal of Research in Personality, 42, 1243-59.
40. Philippi, C.L., Duff, M.C., Denburg, N.L., Tranel, D., Rudrauf, D. (2012). Medial PFC damage abolishes the self-reference effect. Journal of Cognitive Neuroscience, 24, 475-81.
41. Phillips, M.L., Young, A.W., Senior, C., et al. (1997). A specific neural substrate for perceiving facial expressions of disgust. Nature, 389, 495-8.
42. Quadflieg, S., Turk, D.J., Waiter, G.D., Mitchell, J.P., Jenkins, A.C., Macrae, C.N. (2009). Exploring the neural correlates of social stereotyping. Journal of Cognitive Neuroscience, 21, 1560-70.
43. Rorden, C., Brett, M. (2000). Stereotaxic display of brain lesions. Behavioural Neurology, 12, 191-200.
44. Rozin, P., Haidt, J., Fincher, K. (2009). From oral to moral. Science, 323, 1179-80.
45. Rozin, P., Haidt, J., McCauley, C.R. (2000). Disgust. In: Lewis, M., Haviland-Jones, J.M., Barrett, L.F., editors. Handbook of Emotions, 3rd edn. New York: Guilford Press, pp. 757-776.
46. Rozin, P., Lowery, L., Imada, S., Haidt, J. (1999). The CAD Triad hypothesis: a mapping between three moral emotions (Contempt, Anger, Disgust) and three moral codes (Community, Autonomy, Divinity). Journal of Personality and Social Psychology, 76, 574-86.
47. Rozin, P., Markwith, M., McCauley, C. (1994). Sensitivity to indirect contacts with other persons: AIDS aversion as a composite of aversion to strangers, infection, moral taint, and misfortune. Journal of Abnormal Psychology, 103, 495-504.
48. Rudebeck, P.H. (2006). A role for the macaque anterior cingulate gyrus in social valuation. Science, 313, 1310-2.
49. Saver, J.L., Damasio, A.R. (1991). Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial prefrontal damage. Neuropsychologia, 29, 1241-9.
50. Schaich Borg, J., Lieberman, D., Kiehl, K.A. (2008). Infection, Incest, and Iniquity: Investigating the neural correlates of disgust and morality. Journal of Cognitive Neuroscience, 20, 1529-46.
51. Schnall, S., Haidt, J., Clore, G.L., Jordan, A.H. (2008). Disgust as embodied moral judgment. Personality and Social Psychology Bulletin, 34, 1096-109.
52. Sellitto, M., Ciaramelli, E., di Pellegrino, G. (2010). Myopic discounting of future rewards after medial orbitofrontal damage in humans. Journal of Neuroscience, 30, 16429-36.
53. Simpson, J., Carter, S., Anthony, S.H., Overton, P.G. (2006). Is disgust a homogeneous emotion? Motivation and Emotion, 30, 31-41.
54. Spinnler, H., Tognoni, G. (1987). Standardizzazione e taratura italiana di Test Neuropsicologici. Italian Journal of Neurological Sciences, 6(Suppl. 8), 1-20.
55. Stuss, D.T., Levine, B. (2002). Adult clinical neuropsychology: lessons from studies of the frontal lobes. Annual Review of Psychology, 53, 401-33.
56. Tybur, J.M., Lieberman, D., Griskevicius, V. (2009). Microbes, mating and morality: individual differences in three functional domains of disgust. Journal of Personality and Social Psychology, 97, 103-22.
57. Volz, K.G., Kessler, T., von Cramon, D.Y. (2009). In-group as part of the self: in-group favoritism is mediated by medial prefrontal cortex activation. Social Neuroscience, 4, 244-60.
58. Young, L., Bechara, A., Tranel, D., Damasio, H., Hauser, M., Damasio, A. (2010). Damage to ventromedial prefrontal cortex impairs judgment of harmful intent. Neuron, 65, 845-51.