Deficiency of the RIIâ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 17, 2013, Pages

  Zheng, Ruimao ^a   Yang, Linghai ^a   Sikorski, Maria A ^a   Enns, Linda C ^b   Czyzyk, Traci A ^a   Ladiges, Warren C ^b   McKnight, G Stanley ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

CAMP; Exercise; Mouse genetics; Obesity

Indexed keywords

AGOUTI RELATED PEPTIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IIBETA; DOPAMINE 2 RECEPTOR; PEPTIDE; PROOPIOMELANOCORTIN; PROTEIN; SINGLE MINDED 1; STEROIDOGENIC FACTOR 1; UNCLASSIFIED DRUG; CRE RECOMBINASE; INTEGRASE; LEPTIN; PRIMER DNA; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK2 PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL POPULATION; CONTROLLED STUDY; ENZYME DEFICIENCY; HOMEOSTASIS; HYPOTHALAMUS; LOCOMOTION; MOUSE; NERVE CELL; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; BODY WEIGHT; BRAIN; CALORIMETRY; ENERGY METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; GENOTYPE; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGOUTI; MUS;

ADIPOSITY; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; BRAIN; CALORIMETRY, INDIRECT; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIIBETA SUBUNIT; DNA PRIMERS; ENERGY METABOLISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; INTEGRASES; LEPTIN; LOCOMOTION; MICE; MICE, KNOCKOUT; NEURONS; POLYMERASE CHAIN REACTION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES;

MLCS; MLOWN;

EID: 84876847717     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219542110     Document Type: Article

References (42)

1. Cummings DE, et al. (1996) Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature 382(6592):622-626.
2. Schreyer SA, Cummings DE, McKnight GS, LeBoeuf RC (2001) Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice. Diabetes 50(11):2555-2562.
3. Enns LC, et al. (2009) Disruption of protein kinase A in mice enhances healthy aging. PLoS ONE 4(6):e5963.
4. Czyzyk TA, Sikorski MA, Yang L, McKnight GS (2008) Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci USA 105(1):276-281.
5. Newhall KJ, Cummings DE, Nolan MA, McKnight GS (2005) Deletion of the RIIbeta-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-deficient ob/ob mouse. Mol Endocrinol 19(4): 982-991.
6. Nolan MA, Sikorski MA, McKnight GS (2004) The role of uncoupling protein 1 in the metabolism and adiposity of RII beta-protein kinase A-deficient mice. Mol Endocrinol 18(9):2302-2311.
7. Brandon EP, et al. (1998) Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice. J Neurosci 18(10):3639-3649.
8. Cadd G, McKnight GS (1989) Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain. Neuron 3(1):71-79.
9. Planas JV, Cummings DE, Idzerda RL, McKnight GS (1999) Mutation of the RIIbeta subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue. J Biol Chem 274(51):36281-36287.
10. Burton KA, et al. (1997) Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase. Proc Natl Acad Sci USA 94(20):11067-11072.
11. Adams MR, et al. (1997) Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice. Proc Natl Acad Sci USA 94(22):12157-12161.
12. Goris AH, Westerterp KR (2008) Physical activity, fat intake and body fat. Physiol Behav 94(2):164-168.
13. Brownlow BS, Petro A, Feinglos MN, Surwit RS (1996) The role of motor activity in diet-induced obesity in C57BL/6J mice. Physiol Behav 60(1):37-41.
14. Keesey RE, Swiergiel AH, Corbett SW (1990) Contribution of spontaneous activity to daily energy expenditure of adult obese and lean Zucker rats. Physiol Behav 48(2):327-331.
15. Bjursell M, et al. (2008) Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice. Am J Physiol Endocrinol Metab 294(2): E251-E260.
16. He W, et al. (2003) Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA 100(26):15712-15717.
17. Zhu Y, et al. (2001) Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev 15(7): 859-876.
18. Rempe D, et al. (2006) Synapsin I Cre transgene expression in male mice produces germline recombination in progeny. Genesis 44(1):44-49.
19. Tronche F, et al. (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23(1):99-103.
20. Bogush AI, et al. (2005) DARPP-32 genomic fragments drive Cre expression in postnatal striatum. Genesis 42(1):37-46.
21. Heusner CL, Beutler LR, Houser CR, Palmiter RD (2008) Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits. Genesis 46(7): 357-367.
22. Chakravarthy MV, et al. (2007) Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest 117(9):2539-2552.
23. Vong L, et al. (2011) Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71(1):142-154.
24. Ziegler DR, Cullinan WE, Herman JP (2002) Distribution of vesicular glutamate transporter mRNA in rat hypothalamus. J Comp Neurol 448(3):217-229.
25. Virtue S, Even P, Vidal-Puig A (2012) Below thermoneutrality, changes in activity do not drive changes in total daily energy expenditure between groups of mice. Cell Metab 16(5):665-671.
26. Butler AA, Kozak LP (2010) A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes 59(2): 323-329.
27. Kaiyala KJ, et al. (2010) Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes 59(7):1657-1666.
28. Skaper SD, Giusti P (2010) Transgenic mouse models of Parkinson's disease and Huntington's disease. CNS Neurol Disord Drug Targets 9(4):455-470.
29. Beaulieu JM, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63(1):182-217.
30. Amieux PS, et al. (1997) Compensatory regulation of RIalpha protein levels in protein kinase A mutant mice. J Biol Chem 272(7):3993-3998.
31. Ebersole KE, et al. (2008) Energy expenditure and adiposity in Nigerian and African-American women. Obesity (Silver Spring) 16(9):2148-2154.
32. Metcalf BS, et al. (2011) Fatness leads to inactivity, but inactivity does not lead to fatness: a longitudinal study in children (EarlyBird 45). Arch Dis Child 96(10):942-947.
33. Melzer K, Kayser B, Saris WH, Pichard C (2005) Effects of physical activity on food intake. Clin Nutr 24(6):885-895.
34. Kong D, et al. (2012) GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell 151(3):645-657.
35. Cohen P (2002) Protein kinases-the major drug targets of the twenty-first century? Nat Rev Drug Discov 1(4):309-315.
36. Gong S, et al. (2007) Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. J Neurosci 27(37):9817-9823.
37. Postic C, et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274(1):305-315.
38. Balthasar N, et al. (2005) Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505.
39. Dhillon H, et al. (2006) Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49(2): 191-203.
40. Xu AW, et al. (2005) Effects of hypothalamic neurodegeneration on energy balance. PLoS Biol 3(12):e415.
41. Balthasar N, et al. (2004) Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42(6):983-991.
42. Beutler LR, et al. (2011) Balanced NMDA receptor activity in dopamine D1 receptor (D1R)-and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci USA 108(10):4206-4211.