Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease

Current Alzheimer Research

Volumn 10, Issue 3, 2013, Pages 252-260

  Ryu, Jae K ^a   Little, Jonathan P ^b   Klegeris, Andis ^b   Jantaratnotai, Nattinee ^c   McLarnon, James G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

AD animal model; Angiostatin; Antiangiogenic; Immunohistochemis; Intrahippocampal injection of A 1 42; Microgliosis; Vascular endothelial growth factor; Vascular perturbations

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ANGIOSTATIN; LIPOPOLYSACCHARIDE; VASCULOTROPIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN NERVE CELL; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; GLIOSIS; GRANULE CELL; HIPPOCAMPUS; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; MICROVASCULATURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ALZHEIMER DISEASE; ANGIOGENESIS INHIBITORS; ANGIOSTATINS; ANIMALS; BRAIN; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MONOCYTES; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84876840818     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205011310030004     Document Type: Article

References (40)

1. Kalaria RN, Hedera P. Differential degeneration of the cerebral vasculature in Alzheimer's disease. NeuroReport 6:477-480 (1995).
2. Kalaria RN. Small vessel disease and Alzheimer's dementia: pathological considerations. Cerebrovascular Diseases 13: 48-52 (2002).
3. de la Torre. Alzheimer's disease as a vascular disorder: nosological evidence. Stroke 33: 1152-1162 (2002).
4. Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5: 347-360 (2004).
5. Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 28: 202-208 (2005).
6. Benarroch E. Neurovascular unit dysfunction: A vascular component of Alzheimer's disease? Neurology 68: 1730-1732 (2007).
7. Grammas, P. Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease. J Neuroinflamm 8: 26 (2011).
8. Zipser BD, Johanson CE, Gonzalez L, Berzin TM, Tavares R, Hulette CM, et al. Microvascular injury and blood-brain barrier leakage in Alzheimer's disease. Neurobiol Aging 28: 977-986 (2007).
9. Ryu JK, McLarnon JG. A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain. J Cell Mol Med 13:2911-2925 (2009).
10. Bell RD, Zlokovic BV. Neurovascular mechanisms and bloodbrain barrier disorder in Alzheimer's disease. ActaNeuropathol 118: 103-113 (2009).
11. Biron KE, Dickstein DL, Gopaul R, Jefferies WA. Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease. PLoS ONE: 6(8): e23789 (2011).
12. Desai BS, Schneider JA, Li JL, Carvey PM, Hendey B. Evidence of angiogenic vessels in Alzheimer's disease. J Neural Transm 116: 587-597 (2009).
13. Jantaratnotai N, Ryu JK, Schwab C, McGeer PL, McLarnon JG. Comparison of vascular perturbations in an Aβ-injected animal model and in AD brain. Int J Alz Dis: 918280 (2011).
14. Kalaria RN, Cohen DL, Premkumar DRD, LaManna JC, Lust WD. Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia. Molecular Brain Res 62: 101-105 (1998).
15. Tarkowski E, Issa R, Sjogren M, Wallin A, Blennow K, TarkowskiA, et al. Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia. Neurobiol Aging 23: 237-243 (2002).
16. Ryu JK, Cho T, Choi HB, Wang YT, McLarnon JG. Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology. J Neurosci 29: 3-13 (2009).
17. Croll SD, Ransohoff RM, Cai N, Zhang Q, Martin FJ, Wei T, et al. VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol 187: 388-402 (2004).
18. Tarkowski E, Liljeroth AM, Nilsson A, Ricksten A, Davidsson P, Minthon L, et al. TNF gene polymorphism and its relation to intracerebral production of TNFalpha and TNFbeta in AD. Neurology 54: 2077-2081 (2000).
19. Jantaratnotai N, Schwab C, Ryu JK, McGeer PL, McLarnon JG. Converging perturbed microvasculature and microglial clusters characterize Alzheimer disease brain. Curr Alz Res 7: 625-636 (2010).
20. Grammas P, Ovase R. Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiol Aging 22: 837-842 (2001).
21. Zand L, Ryu JK, McLarnon JG. Induction of angiogenesis in the β-amyloid peptide-injected rat hippocampus. Neuro Report 16: 129-132 (2005).
22. Meyer EP, Ulmann-Schuler A, Staufenbiel M, Krucker T. Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease. PNAS 105: 3587-3592 (2008).
23. Ryu JK, McLarnon JG. Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-β in an animal model of inflamed Alzheimer's disease brain. Neurobiol Dis 29: 254-266 (2008).
24. Paul J, Strickland S, Melchor JP. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med 204: 1999-2008 (2007).
25. Kirsch M, Strasser J, Allende R, Bello L, Zhang J, Black PM. Angiostatin suppresses malignant glioma growth in vivo. Cancer Res 58: 4654-4659 (1998).
26. Gyorffy S, Palmer K, Podor TJ, Hitt M, Gauldie J. Combined treatment of a murine breast cancer model with type 5 adenovirus vectors expressing murine angiostatin and IL-12: a role for combined anti-angiogenesis and immunotherapy. J Immunol 166: 6212-6217 (2001).
27. 1-42intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain. Curr Alz Res 5: 475-480 (2008).
28. Madeira JM, Beloukhina N, Boudreau K, Boettcher T, Gurley L, Walker DG, et al. Cobalt(II) beta-ketoaminato complexes as novel inhibitors of neuroinflammation. Eur J Pharmacol 676: 81-88.
29. Hajitou A, Grignet C, Devy L, Berndt S, Blacher S, Deroanne CF, et al. The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells. FASEB J 16: 1802-1804 (2002).
30. Sima J, Zhang SX, Shao C, Fant J, Ma JX. The effect of angiostatin on vascular leakage and VEGF expression in rat retina. FEBS Lett 564: 19-23 (2004).
31. Klegeris A, Walker DG, McGeer PL. Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-β. Brain Res 747: 114-121 (1997).
32. Klegeris A, Bissonnette CJ, McGeer PL. Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system. Neurobiol Aging 26: 673-682 (2005).
33. Paris D, Townsend K, Quadros A, Humphrey J, Sun J, Brem S, et al. Inhibition of angiogenesis by Aβ peptides. Angiogenesis 7: 75-85 (2004).
34. Kawai M, Kalaria RN, Sami HI, Perry G. The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Am J Pathol 137: 1435-1446 (1990).
35. Sawada M, Kondo N, Suzumura A, Marunouchi T. Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res 491: 394-397 (1989).
36. Pogue, AL, Lukiw WJ. Angiogenic signaling in Alzheimer's disease. NeuroReport 15: 1507-1510 (2004).
37. Vagnucci AH, Li WW. Alzheimer's disease and angiogenesis. Lancet 361: 605-608 (2003).
38. Siao CJ, Tsirka SE. Tissue plasminogen activator mediated microglial activation via its finger domain through annexin II. J Neurosci 22: 3352-3358 (2002).
39. Milner R. Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta 5 integrin rolling show no defects in adhesion or MMP 9 expression on vitronectin. Glia 57: 713-723 (2009).
40. Benelli R, Morini M, Carrozzino F, Ferrari N, Minghelli S, Santi L, et al. Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation. FASEB J 16: 267-269 (2002).