Leukoaraiosis on MRI in patients with minimally symptomatic obstructive sleep apnoea

Cerebrovascular Diseases

Volumn 35, Issue 4, 2013, Pages 363-369

  Schulz, Ursula G ^a   Mason, Rebecca H ^b   Craig, Sonya E ^b   Howard, Sally ^a   Nicoll, Deborah J ^b   Kohler, Malcolm ^c   Rothwell, Peter M ^a   Stradling, John R ^b  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Hypertension; Leukoaraiosis; Magnetic resonance imaging; Obstructive sleep apnoea

Indexed keywords

OXYGEN;

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; HYPERTENSION; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN DESATURATION; OXYGEN DESATURATION INDEX; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RATING SCALE; RISK FACTOR; SLEEP DISORDERED BREATHING; WAIST HIP RATIO; DAYTIME SOMNOLENCE; DIASTOLIC BLOOD PRESSURE; HYPOPNEA INDEX; MIDDLE AGED; NECK CIRCUMFERENCE; SYSTOLIC BLOOD PRESSURE; WHITE MATTER LESION;

AGE FACTORS; AGED; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; HYPERTENSION; LEUKOARAIOSIS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PREVALENCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SLEEP APNEA, OBSTRUCTIVE;

EID: 84876814834     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000348845     Document Type: Article

References (29)

1. Grueter BE, Schulz UG: Age-related cerebral white matter disease (leukoaraiosis): A review. Postgrad Med J 2012; 88: 79-87.
2. Pantoni L, Garcia JH: The significance of cerebral white matter abnormalities 100 years after Binswanger's report. Stroke 1995; 26: 1293-1301.
3. Pantoni L, Garcia JH: Pathogenesis of leukoaraiosis: A review. Stroke 1997; 28: 652-659.
4. The LADIS Study Group, 2001-2011: A decade of the LADIS (Leukoaraiosis and Disability) Study: What have we learned about white matter changes and small-vessel disease? Cerebrovasc Dis 2011; 32: 577-588.
5. Melkas S, Sibolt G, Oksala NKJ, Putaala J, Pohj asvaara T, Kaste M, Karhunen PJ, Erkinjuntti T: Extensive white matter changes predict stro ke recurrence up to 5 years after a first-ever isch emic stroke. Cerebrovasc Dis 2012; 34: 191-198.
6. Stradling JR, Crosby JH: Predictors and prevalence of obstructive sleep apnoea and snoring in 1,001 middle aged men. Thorax 1991; 46: 85-90.
7. Kohler M, Stradling JR: Mechanisms of vascular damage in obstructive sleep apnea. Nat Rev Cardiol 2010; 7: 677-685.
8. Marin JM, Carrizo SJ, Vicente E, Agusti AG: Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study. Lancet 2005; 365: 1046-1053.
9. Young T, Peppard PE, Gottlieb DJ: Epidemiology of obstructive sleep apnea: A population health perspective. Am J Respir Crit Care Med 2002; 165: 1217-1239.
10. Pepperell JC, Ramdassingh-Dow S, Crosthwaite N, Mullins R, Jenkinson C, Stradling JR, Davies RJ: Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: A randomised parallel trial. Lancet 2002; 359: 204-210.
11. Harbison J, Gibson GJ, Birchall D, et al: White matter disease and sleep-disordered breathing after acute stroke. Neurology 2003; 61: 359-363.
12. Erkinjuntti T, Partinen M, Sulkava R, et al: Sleep apnea in multiinfarct dementia and Alzheimer's disease. Sleep 1987; 10: 419-425.
13. Davies CW, Crosby JH, Mullins RL, et al: Case control study of cerebrovascular damage defined by magnetic resonance imaging in patients with OSA and normal matched control subjects. Sleep 2001; 24: 715-720.
14. Minoguchi K, Yokoe T, Tazaki T, et al: Silent brain infarction and platelet activation in obstructive sleep apnoea. Am J Respir Crit Care Med 2007; 175: 612-617.
15. Craig SE, Kohler M, Nicoll D, Bratton DJ, Nunn AJ, Davies RJO, Stradling JR: The primary results of the MOSAIC trial: Does CPAP for minimally symptomatic OSA reduce daytime sleepiness or calculated vascular risk? Thorax 2010; 65(suppl 4):A9.
16. Fietze I, Dingli K, Diefenbach K, et al: Nightto-night variation of the oxygen desaturation index in sleep apnoea syndrome. Eur Respir J 2004; 24: 987-993.
17. Punjabi NM, Newman AB, Young TB, et al: Sleep-disordered breathing and cardiovascular disease: An outcome-based definition of hypopneas. Am J Respir Crit Care Med 2008; 177: 1150-1155.
18. Wahlund LO, Barkhof F, Fazekas F, et al: A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke 2001; 32: 1318-1322.
19. Rothwell PM, Howard SC, Dolan E, et al: Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895-905.
20. De Leeuw FE, de Groot JC, Achten E, et al: Prevalence of cerebral white matter lesions in elderly people: A population based magnetic resonance imaging study. The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 2001; 70: 9-14.
21. Kuller LH, Longstreth WT, Arnold AM, et al: White matter hyperintensity on cranial magnetic resonance imaging: A predictor of stroke. Stroke 2004; 35: 1821-1825.
22. Gunstad J, Cohen RA, Tate DF, et al: Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease. Blood Press 2005; 14: 353-358.
23. Van Dijk EJ, Breteler MMB, Schmidt R, et al: The association between blood pressure, hypertension, and cerebral white matter lesions: Cardiovascular Determinants of Dementia Study. Hypertension 2004; 44: 625-630.
24. Godin O, Tzourio C, Maillard P, et al: Antihypertensive treatment and change in blood pressure are associated with the progression of white matter lesion volumes: The Three-City (3C) Dijon Magnetic Resonance Imaging Study. Circulation 2011; 123: 266-273.
25. Kim CK, Kwon H, Lee S, et al: Association of obesity with cerebral microbleeds in neurologically asymptomatic elderly subjects. J Neurol 2012, DOI: 10.1007/s00415-012-6546-y.
26. Kohler M, Stoewhas A, Ayers L, et al: Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea. Am J Respir Crit Care Med 2011; 184: 1192-1199.
27. Robbins J, Redline S, Ervin A, et al: Associations of sleep-disordered breathing and cerebral changes on MRI. J Clin Sleep Med 2005; 1: 159-165.
28. Kamba M, Inoue Y, Higami S, Suto Y, Ogawa T, Chen W: Cerebral metabolic impairment in patients with obstructive sleep apnoea: An independent association of obstructive sleep apnoea with white matter change. J Neurol Neurosurg Psychiatry 2001; 71: 334-339.
29. Macey PM, Kumar R, Woo MA, Valladares EM, Yan-Go FL, Harper RM: Brain structural changes in obstructive sleep apnea. Sleep 2008; 31: 967-977.