Association of obesity with cerebral microbleeds in neurologically asymptomatic elderly subjects

Journal of Neurology

Volumn 259, Issue 12, 2012, Pages 2599-2604

  Kim, Chi Kyung ^a   Kwon, Hyung Min ^a   Lee, Seung Hoon ^a   Kim, Beom Joon ^a   Ryu, Wi Sun ^a   Kwon, Hyuk Tae ^b,c   Yoon, Byung Woo ^a  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University Boramae Hospital   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Body mass index; Cerebral microbleeds; Hemorrhage; Obesity; Small vessel disease

Indexed keywords

ADULT; ARTERIOSCLEROSIS; ARTICLE; BODY MASS; BRAIN HEMORRHAGE; CEREBROVASCULAR DISEASE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PREVALENCE; PRIORITY JOURNAL; RADIODIAGNOSIS; SEROPREVALENCE; WORLD HEALTH ORGANIZATION;

AGED; AGED, 80 AND OVER; ASYMPTOMATIC DISEASES; CEREBRAL HEMORRHAGE; CEREBRAL SMALL VESSEL DISEASES; FEMALE; HUMANS; MALE; MICROCIRCULATION; NERVOUS SYSTEM DISEASES; OBESITY; RISK FACTORS;

EID: 84872109998     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-012-6546-y     Document Type: Article

References (27)

1. Bazzano LA, Gu D, Whelton MR, Wu X, Chen CS, Duan X, Chen J, Chen JC, He J (2010) Body mass index and risk of stroke among Chinese men and women. Ann Neurol 67:11-20
2. Biffi A, Greenberg GM (2011) Cerebral amyloid angiopathy: a systematic review. J Clin Neurol 7:1-9
3. Chobanian AV, Bakaris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr., Roccella EJ (2003) The seventh report of the joint committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 Report. JAMA 289:2560-2572
4. Fantin F, Di Francesco V, Rossi A, Giuliano K, Marino F, Cazzadori M, Gozzoli MP, Vivian ME, Bosello O, Rajkumar C, Zamboni M (2010) Abdominal obesity and subclinical vascular damage in the elderly. J Hypertens 28:333-339
5. Fazekas F, Niederkorn K, Schmidt R, Offenbacher H, Horner S, Bertha G, Lechner H (1988) White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke 19:1285-1288
6. Greenberg SM, Eng JA, Ning M, Smith EE, Rosand J (2004) Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke 35:1415-1420
7. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, Launer LJ, Van Buchem MA, Breteler MM (2009) Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 8:165-174
8. Haslam DW, James WP (2005) Obesity. Lancet 366:1197-1209
9. Kato H, Izumiyama M, Izumiyama K, Takahashi A, Itoyama Y (2002) Silent cerebral microbleeds on T2-weighted MRI: correlation with stroke subtype, stroke recurrence, and leukoaraiosis. Stroke 33:1536-1540
10. Knudsen KA, Rosand J, Karluk D, Greenberg SM (2001) Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 56:537-539
11. Kurth T, Gaziano JM, Rexrode KM, Kase CS, Cook NR, Manson JE, Buring JE (2005) Prospective study of body mass index and risk of stroke in apparently healthy women. Circulation 111:1992-1998
12. Kwon HM, Kim BJ, Park JH, Ryu WS, Kim CK, Lee SH, Ko SB, Nam H, Lee YS, Yoon BW (2009) Significant association of metabolic syndrome with silent brain infarction in elderly people. J Neurol 256:1825-1831
13. Lavie CJ, Milani RV, Ventura HO (2009) Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 53:1925-1932
14. Lee SH, Kwon SJ, Kim KS, Yoon BW, Roh JK (2004) Cerebral microbleeds in patients with hypertensive stroke: topographical distribution in the supratentorial area. J Neurol 251:1183-1189
15. Mayanagi K, Katakam PV, Gaspar T, Domoki F, Busija DW (2008) Acute treatment with rosuvastatin protects insulin resistant (C57BL/6 J ob/ob) mice against transient cerebral ischemia. J Cereb Blood Flow Metab 28:1927-1935
16. McColl BW, Rose N, Robson FH, Rothwell NJ, Lawrence CB (2010) Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke. J Cereb Blood Flow Metab 30:267-272
17. Ni Mhurchu C, Rodgers A, Pan WH, Gu DF, Woodward M (2004) Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310,000 participants. Int J Epidemiol 33:751-758
18. Pantoni L (2010) Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9:689-701
19. Rexrode KM, Hennekens CH, Willett WC, Colditz GA, Stampfer MJ, Rich-Edwards JW, Speizer FE, Manson JE (1997) A prospective study of body mass index, weight change, and risk of stroke in women. JAMA 277:1539-1545
20. Singer G, Granger DN (2007) Inflammatory responses underlying the microvascular dysfunction associated with obesity and insulin resistance. Microcirculation 14:375-387
21. Soo YO, Yang SR, Lam WW, Wong A, Fan YH, Leung HH, Chan AY, Leung C, Leung TW, Wong LK (2008) Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds. J Neurol 255:1679-1686
22. Tanaka A, Ueno Y, Nakayama Y, Takano K, Takebayashi S (1999) Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas. Stroke 30:1637-1642
23. Terao S, Yilmaz G, Stokes KY, Ishikawa M, Kawase T, Granger DN (2008) Inflammatory and injury responses to ischemic stroke in obese mice. Stroke 39:943-950
24. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, Krestin GP, Breteler MM (2008) Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 70:1208-1214
25. Winter Y, Rohrmann S, Linseisen J, Lanczik O, Ringleb PA, Hebebrand J, Back T (2008) Contribution of obesity and abdominal fat mass to risk of stroke and transient ischemic attacks. Stroke 39:3145-3151
26. Woo D, Sauerbeck LR, Kissela BM, Khoury JC, Szaflarski JP, Gebel J, Shukla R, Pancioli AM, Jauch EC, Menon AG, Deka R, Carrozzella JA, Moomaw CJ, Fontaine RN, Broderick JP (2002) Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke 33:1190-1195
27. World Health Organization International Association for the Study of Obesity, International Obesity Task Force (2000) The Asia-Pacific perspectives: redefining obesity and its treatment. Health Communications, Sydney