Post-neonatal health and development of children born after assisted reproduction: A systematic review of controlled studies

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 127, Issue 1, 2006, Pages 3-25

  Ludwig, A K ^a   Sutcliffe, A G ^b   Diedrich, K ^a   Ludwig, M ^c  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c ENDOKRINOLOGIKUM HAMBURG   (Germany)

Author keywords

Assisted reproductive technologies; Children; Follow up; Health; Systematic review

Indexed keywords

ARTIFICIAL INSEMINATION; CHILD BEHAVIOR; CHILD DEVELOPMENT; CHILD GROWTH; CHILD HEALTH; CHILDBIRTH; CHILDHOOD CANCER; CONGENITAL MALFORMATION; FERTILIZATION IN VITRO; GESTATIONAL AGE; HUMAN; INFERTILITY; INTRACYTOPLASMIC SPERM INJECTION; LOW BIRTH WEIGHT; MATERNAL AGE; MEDICAL LITERATURE; MEDLINE; MENTAL DEVELOPMENT; NEUROLOGICAL COMPLICATION; OUTCOMES RESEARCH; PEDIATRIC SURGERY; PHYSICAL EXAMINATION; PREGNANCY; PRIORITY JOURNAL; PSYCHOMOTOR DEVELOPMENT; PUBLICATION; REGISTER; REVIEW; RISK FACTOR; SMALL FOR DATE INFANT; SYSTEMATIC REVIEW; TWIN PREGNANCY;

EID: 33745392167     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2006.02.009     Document Type: Review

References (81)

1. Stouffer R.L. Pre-ovulatory events in the rhesus monkey follicle during ovulation induction. Reprod Biomed 4 Suppl 3 (2002) 1-4 [Online]
2. Ertzeid G., and Storeng R. The impact of ovarian stimulation on implantation and fetal development in mice. Hum Reprod 16 (2001) 221-225
3. Shi W., and Haaf T. Aberrant methylation patterns at the two-cell stage as an indicator of early developmental failure. Mol Reprod Dev 63 (2002) 329-334
4. Young L.E., Fernandes K., McEvoy T.G., Butterwith S.C., Gutierrez C.G., Carolan G., et al. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nat Genet 27 (2001) 153-154
5. Terada Y., Luetjens C.M., Sutovsky P., and Schatten G. Atypical decondensation of the sperm nucleus, delayed replication of the male genome, and sex chromosome positioning following intracytoplasmic human sperm injection (ICSI) into golden hamster eggs: does ICSI itself introduce chromosomal anomalies?. Fertil Steril 74 3 (2000) 454-460
6. Ludwig M., Schröder A.K., and Diedrich K. Impact of intracytoplasmativ sperm injection on the activation and fertilization process of oocytes. Reprod Biomed 3 (2001) 230-240 [Online]
7. Schröder A.K., Diedrich K., and Ludwig M. Fertilization and preimplantation development after intracytoplasmatic sperm injection. Reprod Biomed 3 (2001) 241-249 [Online]
8. Egozcue S., Blanco J., Vendrell J.M., et al. Human male infertility: chromosome anomalies, meiotic disorders, abnormal spermatozoa and recurrent abortion. Hum Reprod Update 6 1 (2000) 93-105
9. Marques C.J., Carvalho F., Sousa M., and Barros A. Genomic imprinting in disruptive spermatogenesis. Lancet 363 9422 (2004) 1700-1702
10. Hewitson L., Dominko T., Taketani D., et al. Unique checkpoints during the first cell cycles of fertilization and intracytoplasmatic sperm injection in rhesus monkeys. Nat Med 5 (1999) 431-433
11. Ludwig M., and Katalinic A. Pregnancy course and health of children born after ICSI depending on parameters of male factor infertility. Hum Reprod 18 2 (2003) 351-357
12. Schieve L.A., Meikle S.F., Ferre C., Peterson H.B., Jeng G., and Wilcox L.S. Low and very low birth weight in infants conceived with use of assisted reproduction technology. N Engl J Med 346 (2002) 731-737
13. Katalinic A., Rosch C., and Ludwig M. Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study. Fertil Steril 81 6 (2004) 1604-1616
14. Jackson R.A., Gibson K.A., Wu Y.W., and Croughan M.S. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 103 3 (2004) 551-563
15. Helmerhorst F.M., Perquin D.A., Donker D., and Keirse M.J. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 328 7434 (2004) 261
16. Hansen M., Kurinczuk J.J., Bower C., and Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 346 (2002) 725-730
17. Bonduelle M., Liebaers I., Deketelaere V., Devroey P., and Devro. Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999). Hum Reprod 17 (2002) 671-694
18. Hansen M., Bower C., Milne E., de Klerk N., and Kurinczuk J. Assisted reproductive technologies and the risk of birth defects-a systematic review. Hum Reprod 20 2 (2005) 328-338
19. Ericson A., Nygren K.G., Olausson P.O., and Kallen B. Hospital care utilization of infants born after IVF. Hum Reprod 17 4 (2002) 929-932
20. Bergh C. Single embryo transfer: a mini-review. Hum Reprod 20 2 (2005) 323-327
21. Pinborg A., Loft A., Rasmussen S., and Nyboe Andersen A. Hospital care utilization of IVF/ICSI twins following until 2-7 years of age: a controlled Danish national cohort study. Hum Reprod 19 (2004) 2529-2536
22. Lidegaard O., Pinborg A., and Andersen A.N. Imprinting diseases and IVF: Danish National IVF cohort study. Hum Reprod (2005)
23. La Sala G.B., Gallinelli A., Fagandini P., et al. Developmental outcomes at one and two years of children conceived by intracytoplasmic sperm injection. Int J Fertil Womens Med 49 3 (2004) 113-119
24. Papaligoura Z., Panopoulou-Maratou O., Solman M., Arvaniti K., and Sarafidou J. Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents. Hum Reprod 19 6 (2004) 1488-1493
25. Wennerholm U., Bergh C., Niklasson A., et al. Health and development in children after ICSI. Hum Reprod 18 (2003) xviii 102 [Abstract book]
26. Leslie G.I., Gibson F.L., McMahon C., Cohen J., Saunders D.M., and Tennant C. Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age. Hum Reprod 18 10 (2003) 2067-2072
27. Sydsjo G., Wadsby M., Kjellberg S., and Sydsjo A. Relationships and parenthood in couples after assisted reproduction and in spontaneous primiparous couples: a prospective long-term follow-up study. Hum Reprod 17 12 (2002) 3242-3250
28. Montgomery T.R., Aiello F., Adelman R.D., Wasylyshyn N., Andrews M.C., Brazelton T.B., et al. The psychological status at school age of children conceived by in-vitro fertilization. Hum Reprod 14 8 (1999) 2162-2165
29. Leslie G.I., Gibson F.L., McMahon C., Tennant C., and Saunders D.M. Infants conceived using in-vitro fertilization do not over-utilize health care resources after the neonatal period. Hum Reprod 13 (1998) 2055-2059
30. Levy-Shiff R., Vakil E., Dimitrovsky L., et al. Medical, cognitive, emotional, and behavioral outcomes in school-age children conceived by in-vitro fertilization. J Clin Child Psychol 27 3 (1998) 320-329
31. Cederblad M., Friberg B., Ploman F., Sjoberg N.O., Stjernqvist K., and Zackrisson E. Intelligence and behaviour in children born after in-vitro fertilization treatment. Hum Reprod 11 9 (1996) 2052-2057
32. Sutcliffe A.G., D'Souza S.W., Cadman J., Richards B., McKinlay I.A., and Lieberman B. Minor congenital anomalies, major congenital malformations and development in children conceived from cryopreserved embryos. Hum Reprod 10 12 (1995) 3332-3337
33. Bonduelle M., Wennerholm U.B., Loft A., et al. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod 20 2 (2005) 413-419
34. Koivurova S., Hartikainen A.L., Sovio U., Gissler M., Hemminki E., and Jarvelin M.R. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod 18 11 (2003) 2328-2336
35. Wennerholm U.B., Albertsson-Wikland K., Bergh C., et al. Postnatal growth and health in children born after cryopreservation as embryos. Lancet 351 9109 (1998) 1085-1090
36. Bonduelle M., Bergh C., Niklasson A., Palermo G.D., and Wennerholm U.B. Medical follow-up study of 5-year-old ICSI children. Reprod Biomed 9 1 (2004) 91-101 [Online]
37. Pinborg A., Loft A., Schmidt L., and Andersen A.N. Morbidity in a Danish national cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families. Hum Reprod 18 6 (2003) 1234-1243
38. Place I., and Englert Y. A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization. Fertil Steril 80 6 (2003) 1388-1397
39. Bowen J.R., Gibson F.L., Leslie G.I., and Saunders D.M. Medical and developmental outcome at 1 year for children conceived by intracytoplasmic sperm injection. Lancet 351 9115 (1998) 1529-1534
40. Raoul-Duval A., Bertrand-Servais M., Letur-Konirsch H., and Frydman R. Psychological follow-up of children born after in-vitro fertilization. Hum Reprod 9 6 (1994) 1097-1101
41. Saunders K., Spensley J., Munro J., and Halasz G. Growth and physical outcome of children conceived by in vitro fertilization. Pediatrics 97 5 (1996) 688-692
42. Ron-El R., Lahat E., Golan A., Lerman M., Bukovsky I., and Herman A. Development of children born after ovarian superovulation induced by long-acting gonadotropin-releasing hormone agonist and menotropins, and by in vitro fertilization. J Pediatr 125 5 Pt 1 (1994) 734-737
43. Morin N.C., Wirth F.H., Johnson D.H., et al. Congenital malformations and psychosocial development in children conceived by in vitro fertilization. J Pediatrics 115 2 (1989) 222-227
44. Stromberg B., Dahlquist G., Ericson A., Finnstrom O., Koster M., and Stjernqvist K. Neurological sequelae in children born after in-vitro fertilisation: a population-based study. Lancet 359 9305 (2002) 461-465
45. Brandes J.M., Scher A., Itzkovits J., Thaler I., Sarid M., and Gershoni-Baruch R. Growth and development of children conceived by in vitro fertilization. Pediatrics 90 3 (1992) 424-429
46. Gershoni-Baruch R., Scher A., Itskovitz J., Thaler I., and Brandes J.M. The physical and psychomotor development of children conceived by IVF and exposed to high-frequency vaginal ultrasonography (6.55 MHz) in the first trimester of pregnancy. Ultrasound Obstet Gynecol 1 1 (1991) 21-28
47. Pinborg A., Loft A., Schmidt L., Greisen G., Rasmussen S., and Andersen A.N. Neurological sequelae in twins born after assisted conception: controlled national cohort study. BMJ 329 7461 (2004) 311
48. Ponjaert-Kristoffersen I., Tjus T., Nekkebroeck J., et al. Psychological follow-up study of 5-year-old ICSI children. Hum Reprod 19 12 (2004) 2791-2797
49. Gibson F.L., Ungerer J.A., Leslie G.I., Saunders D.M., and Tennant C.C. Development, behaviour and temperament: a prospective study of infants conceived through in-vitro fertilization. Hum Reprod 13 6 (1998) 1727-1732
50. Sutcliffe A.G., Taylor B., Grudzinskas G., Thornton S., and Lieberman B. Children conceived after intracytoplasmatic sperm injection. Lancet 352 (1998) 578-579
51. Sutcliffe A.G., Taylor B., Saunders K., Thornton S., Lieberman B.A., and Grudzinskas J.G. Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study. Lancet 357 9274 (2001) 2080-2084
52. Colpin H., and Soenen S. Parenting and psychosocial development of IVF children: a follow-up study. Hum Reprod 17 4 (2002) 1116-1123
53. Barnes J., Sutcliffe A.G., Kristoffersen I., et al. The influence of assisted reproduction on family functioning and children's socio-emotional development: results from a European study. Hum Reprod 19 6 (2004) 1480-1487
54. Cook R., Bradley S., and Golombok S. A preliminary study of parental stress and child behaviour in families with twins conceived by in-vitro fertilization. Hum Reprod 13 11 (1998) 3244-3246
55. Brinton L.A., Kruger K.S., Thomsen B.L., et al. Childhood tumor risk after treatment with ovulation-stimulating drugs. Fertil Steril 81 4 (2004) 1083-1091
56. Doyle P., Bunch K.J., Beral V., and Draper G.J. Cancer incidence in children conceived with assisted reproduction technology. Lancet 352 9126 (1998) 452-453
57. Klip H., Burger C.W., de Kraker J., and van Leeuwen F.E. Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF. Hum Reprod 16 11 (2001) 2451-2458
58. Bradbury B.D., and Jick H. In vitro fertilization and childhood retinoblastoma. Br J Clin Pharmacol 58 2 (2004) 209-211
59. Lerner-Geva L., Toren A., Chetrit A., et al. The risk for cancer among children of women who underwent in vitro fertilization. Cancer 88 12 (2000) 2845-2847
60. Sutcliffe A.G. IVF children, the first generation. Assisted reproduction and child development. 1st ed. (2002), Panthenon Publishing
61. Bergh T., Ericson A., Hillensjo T., Nygren K.G., and Wennerholm U.B. Deliveries and children born after in-vitro fertilisation in Sweden 1982-1995: a retrospective cohort study. Lancet 354 9190 (1999) 1579-1585 [see comments]
62. Bruinsma F., Venn A., Lancaster P., Speirs A., and Healy D. Incidence of cancer in children born after in-vitro fertilization. Hum Reprod 15 3 (2000) 604-607
63. Moll A.C., Imhof S.M., Cruysberg J.R., Schouten-van Meeteren A.Y., Boers M., and van Leeuwen F.E. Incidence of retinoblastoma in children born after in-vitro fertilisation. Lancet 361 9354 (2003) 309-310
64. BenEzra D. In vitro fertilisation and retinobalstoma. Lancet 361 (2003) 273-274
65. Kramer S., Ward E., and Meadows A.T. Medical drug risk factors associated with neuroblastoma: a case-control study. J Natl Cacner Inst 78 (1987) 797-804
66. Michalek A.M., Buck G.M., and Nasca P.C. Gravid health status, medication use, and risk of neuroblastoma. Am J Epidemiol 143 (1996) 996-1001
67. Roman E., Ansell P., and Bull D. Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease?. Br J Cancer 76 (1997) 406-435
68. Steensel-Moll H.A., Valkenburg H.A., and Vanderbroucke J.P. Are maternal fertility problems related to childhood leukaemia?. J Epidemiol 14 (1985) 555-559
69. Pharoah P.O.D., and Adi Y. Consequences of in-utero death in a twin pregnancy. Lancet 355 (2003) 1597-1602
70. Landy H.J., and Keith L.G. The vanishing twin: a review. Hum Reprod Update 4 (1998) 177-183
71. Dimitriou G., Pharoah P.O., Nicolaides K.H., and Greenough A. Cerebral palsy in triplet pregnancies with and without iatrogenic reduction. Eur J Pediatrics 163 8 (2004) 449-451
72. Geva E., Lerner-Geva L., Stavorovsky Z., Modan B., Freedman L., Amit A., et al. Multifetal pregnancy reduction: a possible risk factor for periventricular leukomalacia in premature newborns. Fertil Steril 69 5 (1998) 845-850
73. Leunens L., Celestin-Westreich S., Belva F., and Bonduelle M. Developmental outcome of 8-year old ICSI children. Hum Reprod 19 (2004) i112 [Abstract book]
74. Belva F., Boelaert K., Leunens L., Liebaers I., and Bonduelle M. Medical outcome of 8-year-old ICSI children. Hum Reprod 19 (2004) i112 [Abstract book]
75. Ponjaert-Kristoffersen I. Cognitive and neurodevelopmental outcome. Hum Reprod 18 (2003) xvii97 (Abstract book)
76. Golombok S., Brewaeys A., Giavazzi M.T., Guerra D., MacCallum F., and Rust J. The European study of assisted reproduction families: the transition to adolescence. Hum Reprod 17 3 (2002) 830-840
77. Golombok S., Brewaeys A., Cook R., et al. The European study of assisted reproduction families: family functioning and child development. Hum Reprod 11 10 (1996) 2324-2331
78. Golombok S., MacCallum F., and Goodman E. The test-tube" generation: parent-child relationships and the psychological well-being of in vitro fertilization children at adolescence. Child Dev 72 2 (2001) 599-608
79. Golombok S., Cook R., Bish A., and Murray C. Families created by the new reproductive technologies: quality of parenting and social and emotional development of the children. Child Dev 66 2 (1995) 285-298
80. Sutcliffe A.G., Saunders K., McLachlan R., et al. A retrospective case-control study of developmental and other outcomes in a cohort of Australian children conceived by intracytoplasmic sperm injection compared with a similar group in the United Kingdom. Fertil Steril 79 3 (2003) 512-516
81. Sutcliffe A.G., Taylor B., Li J., Thornton S., Grudzinskas J.G., and Lieberman B.A. Children born after intracytoplasmic sperm injection: population control study. BMJ 318 7185 (1999) 704-705