Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients

Journal of Investigative Dermatology

Volumn 129, Issue 9, 2009, Pages 2220-2232

  Luiten, Rosalie M ^a   Van Den Boorn, Jasper G ^a   Konijnenberg, Debby ^a   Dellemijn, Trees A M ^b   Van Der Veen, J P Wietze ^a   Bos, Jan D ^a   Melief, Cornelis J M ^c   Vyth Dreese, Florry A ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; BODY SURFACE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DEPIGMENTATION; HUMAN; IMMUNOSTIMULATION; LYMPHOCYTIC INFILTRATION; MELANOCYTE; MICROENVIRONMENT; PIGMENT CELL; PRIORITY JOURNAL; SKIN BIOPSY; SKIN DEFECT; T LYMPHOCYTE; TISSUE INJURY; VITILIGO;

APOPTOSIS; AUTOIMMUNITY; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MELANOCYTES; SKIN; T-LYMPHOCYTES; VITILIGO;

EID: 70349731750     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.32     Document Type: Article

References (35)

1. Aarvak T, Chabaud M, Miossec P, Natvig JB (1999) IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J Immunol 162:1246-1251
2. Altman JD, Moss PA, Goulder PJ, Barouch DH, Heyzer-Williams MG, Bell JI et al. (1996) Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94-96
3. Arnold R, Seifert M, Asadullah K, Volk HD (1999) Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines. J Immunol 162:7140-7147
4. Badri AM, Todd PM, Garioch JJ, Gudgeon JE, Stewart DG, Goudie RB (1993) An immunohistological study of cutaneous lymphocytes in vitiligo. J Pathol 170:149-155
5. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M et al. (2003) Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 281:65-78
6. Bhawan J, Bhutani LK (1983) Keratinocyte damage in vitiligo. J Cutan Pathol 10:207-212
7. Casazza JP, Betts MR, Price DA, Precopio ML, Ruff LE, Brenchley JM et al. (2006) Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. J Exp Med 203:2865-2877
8. Chattopadhyay PK, Yu J, Roederer M (2005) A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles. Nat Med 11:1113-1117
9. Chowdhury D, Lieberman J (2008) Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol 26:389-420
10. Cui J, Bystryn JC (1995) Melanoma and vitiligo are associated with antibody responses to similar antigens on pigment cells. Arch Dermatol 131:314-318
11. Dickinson AM, Sviland L, Carey P, Reid MM, Hamilton PJ, Pearson AJ et al. (1988) Skin explant culture as a model for cutaneous graft-versus-host disease in humans. Bone Marrow Transplant 3:323-329
12. Dickinson AM, Wang XN, Sviland L, Vyth-Dreese FA, Jackson GH, Schumacher TN et al. (2002) In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens. Nat Med 8:410-414
13. Dudley ME, Wunderlich JR, Robbins PF, Yang JC, Hwu P, Schwartzentruber DJ et al. (2002) Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298:850-854
14. Hann SK, Park YK, Lee KG, Choi EH, Im S (1992) Epidermal changes in active vitiligo. J Dermatol 19:217-222
15. Hooijberg E, Ruizendaal JJ, Snijders PJ, Kueter EW, Walboomers JM, Spits H (2000) Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol 165:4239-4245
16. Koga C, Kabashima K, Shiraishi N, Kobayashi M, Tokura Y (2008) Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol 128:2625-2630
17. Korn T, Oukka M, Kuchroo V, Bettelli E (2007) Th17 cells: effector T cells with inflammatory properties. Semin Immunol 19:362-371
18. Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, Kolls J et al. (2007) Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol 178:6730-6733
19. Luiten RM, Kueter EW, Mooi W, Gallee MP, Rankin EM, Gerritsen WR et al. (2005) Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients. J Clin Oncol 23:8978-8991
20. Moellmann G, Klein-Angerer S, Scollay DA, Nordlund JJ, Lerner AB (1982) Extracellular granular material and degeneration of keratinocytes in the normally pigmented epidermis of patients with vitiligo. J Invest Dermatol 79:321-330
21. Montes L, Pfister R, Wilborn W, Elizalde F (2002) Vitiligo. Lancet 360:405
22. Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A et al. (2008) Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112:362-373
23. Myers LM, Vella AT (2005) Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation. Trends Immunol 26:440-446
24. Ogg GS, Rod DP, Romero P, Chen JL, Cerundolo V (1998) High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo. J Exp Med 188:1203-1208
25. Palermo B, Garbelli S, Mantovani S, Scoccia E, Da Prada GA, Bernabei P et al. (2005) Qualitative difference between the cytotoxic T lymphocyte responses to melanocyte antigens in melanoma and vitiligo. Eur J Immunol 35:3153-3162
26. Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ et al. (2003) Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA 100:8372-8377
27. Raj D, Brash DE, Grossman D (2006) Keratinocyte apoptosis in epidermal development and disease. J Invest Dermatol 126:243-257
28. Teunissen MB, Koomen CW, de Waal MR, Wierenga EA, Bos JD (1998) Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 111:645-649
29. Trautmann A, Akdis M, Kleemann D, Altznauer F, Simon HU, Graeve T et al. (2000) T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest 106:25-35
30. van den Boorn JG, Le Poole IC, Luiten RM (2006) T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. Int Rev Immunol 25:235-258
31. van den Wijngaard RM, Wankowicz-Kalinska A, Le PC, Tigges B, Westerhof W, Das P (2000) Local immune response in skin of generalized vitiligo patients. Destruction of melanocytes is associated with the prominent presence of CLA+ T cells at the perilesional site. Lab Invest 80:1299-1309
32. Verra NC, Jorritsma A, Weijer K, Ruizendaal JJ, Voordouw A, Weder P et al. (2004) Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice. Cancer Res 64:2153-2161
33. Vogelsang GB, Hess AD, Berkman AW, Tutschka PJ, Farmer ER, Converse PJ et al. (1985) An in vitro predictive test for graft versus host disease in patients with genotypic HLA-identical bone marrow transplants. N Engl J Med 313:645-650
34. Wankowicz-Kalinska A, van den Wijngaard RM, Tigges BJ, Westerhof W, Ogg GS, Cerundolo V et al. (2003) Immunopolarization of CD4+ and CD8+ T cells to Type-1-like is associated with melanocyte loss in human vitiligo. Lab Invest 83:683-695
35. Yee C, Thompson JA, Roche P, Byrd DR, Lee PP, Piepkorn M et al. (2000) Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo. J Exp Med 192:1637-1644