Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity

Clinical and Experimental Immunology

Volumn 172, Issue 3, 2013, Pages 455-465

  Jurickova, I ^a   Collins, M H ^a   Chalk, C ^a   Seese, A ^a   Bezold, R ^a   Lake, K ^a   von Allmen, D ^a   Frischer, J S ^a   Falcone, R A ^a   Trapnell, B C ^a   Denson, L A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Bacterial killing; Cytokine autoantibody; Granulocyte macrophage colony stimulating factor; Neutrophil; Paediatric Crohn disease; Stricture; Surgery

Indexed keywords

COLONY STIMULATING FACTOR 1; CORTICOSTEROID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR ANTIBODY; IMMUNOGLOBULIN G; INFLIXIMAB; MESALAZINE; STAT5 PROTEIN;

ADOLESCENT; ANTIBODY PRODUCTION; ARTICLE; BACTERICIDAL ACTIVITY; CELL CULTURE; CELL ISOLATION; CHILD; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROHN DISEASE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTESTINE BIOPSY; LAMINA PROPRIA; MALE; MONONUCLEAR CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCHOOL CHILD;

ADOLESCENT; ANTIBODIES, NEUTRALIZING; AUTOANTIBODIES; BLOOD BACTERICIDAL ACTIVITY; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CONSTRICTION, PATHOLOGIC; CROHN DISEASE; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; ILEUM; INFANT; MALE; NEUTROPHILS; STAPHYLOCOCCUS AUREUS; STAT5 TRANSCRIPTION FACTOR; YOUNG ADULT;

EID: 84876742327     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12076     Document Type: Article

References (17)

1. Danese S. New therapies for inflammatory bowel disease: from the bench to the bedside. Gut 2012; 61:918-932.
2. Colombel JF, Sandborn WJ, Reinisch W etal. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med 2010; 362:1383-1395.
3. Watanabe M, Uchida K, Nakagaki K etal. High avidity cytokine autoantibodies in health and disease: pathogenesis and mechanisms. Cytokine Growth Factor Rev 2010; 21:263-273.
4. Uchida K, Beck DC, Yamamoto T etal. GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. N Engl J Med 2007; 356:567-579.
5. Ebert EC, Das KM, Mehta V etal. Non-response to infliximab may be due to innate neutralizing anti-tumour necrosis factor-alpha antibodies. Clin Exp Immunol 2008; 154:325-331.
6. Ebert EC, Panja A, Das KM etal. Patients with inflammatory bowel disease may have a transforming growth factor-beta-, interleukin (IL)-2- or IL-10-deficient state induced by intrinsic neutralizing antibodies. Clin Exp Immunol 2009; 155:65-71.
7. Han X, Uchida K, Jurickova I etal. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology 2009; 136:1261-1271, e1-3.
8. Egea L, Hirata Y, Kagnoff MF. GM-CSF: a role in immune and inflammatory reactions in the intestine. Expert Rev Gastroenterol Hepatol 2010; 4:723-731.
9. Bernasconi E, Favre L, Maillard MH etal. Granulocyte-macrophage colony-stimulating factor elicits bone marrow-derived cells that promote efficient colonic mucosal healing. Inflamm Bowel Dis 2010; 16:428-441.
10. Han X, Gilbert S, Groschwitz K etal. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut 2010; 59:1066-1078.
11. Kelsen JR, Rosh J, Heyman M etal. Phase I trial of sargramostim in pediatric Crohn's disease. Inflamm Bowel Dis 2010; 16:1203-1208.
12. Korzenik JR, Dieckgraefe BK, Valentine JF etal. Sargramostim for active Crohn's disease. N Engl J Med 2005; 352:2193-2201.
13. Sainathan SK, Hanna EM, Gong Q etal. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm Bowel Dis 2007; 14:88-99.
14. Carey R, Jurickova I, Ballard E etal. Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease. Inflamm Bowel Dis 2008; 14:446-457.
15. Willson TA, Kuhn BR, Jurickova I etal. STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease. J Pediatr Gastroenterol Nutr 2012; 55:32-43.
16. Goldstein JI, Kominsky DJ, Jacobson N etal. Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology 2011; 141:208-216.
17. Nylund CM, D'Mello S, Kim MO etal. Granulocyte-macrophage colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease. J Pediatr Gastroenterol Nutr 2011; 52:542-548.