Association between plasma transfusions and clinical outcome in critically ill children: A prospective observational study

Vox Sanguinis

Volumn 104, Issue 4, 2013, Pages 342-349

  Karam, O ^a   Lacroix, J ^b   Robitaille, N ^b   Rimensberger, P C ^a   Tucci, M ^b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Blood component transfusion; Child; Critical illness; Mortality; Multiple organ failure; Plasma

Indexed keywords

FRESH FROZEN PLASMA;

ADOLESCENT; ADULT; ARTICLE; BLOOD CLOTTING DISORDER; BODY WEIGHT; CHILD; CHILDHOOD MORTALITY; CRITICALLY ILL PATIENT; DISEASE SEVERITY; FEMALE; HOSPITAL INFECTION; HUMAN; INCIDENCE; INFANT; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; NEWBORN; OBSERVATIONAL STUDY; PLASMA TRANSFUSION; PRACTICE GUIDELINE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; BLOOD COMPONENT TRANSFUSION; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; HUMANS; INCIDENCE; MIDDLE AGED; PLASMA; PROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84876731695     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/vox.12009     Document Type: Article

References (33)

1. Report of the US Department of Health and Human Services: The 2009 National Blood Collection and Utilization Survey Report. Washington, DC, US Department of Health and Human Services, Office of the Assistant Secretary for Health, 2011.
2. Luk C, Eckert KM, Barr RM, et al.: Prospective audit of the use of fresh-frozen plasma, based on Canadian Medical Association transfusion guidelines. CMAJ 2002; 166:1539-1540.
3. Puetz J, Witmer C, Huang Y-SV, et al.: Widespread Use of Fresh Frozen Plasma in US Children's Hospitals Despite Limited Evidence Demonstrating a Beneficial Effect. J Pediatr 2012; 160:210-215.
4. Stanworth SJ, Walsh TS, Prescott RJ, et al.: A national study of plasma use in critical care: clinical indications, dose and effect on prothrombin time. Crit Care 2011; 15:R108.
5. Stanworth SJ: The evidence-based use of FFP and cryoprecipitate for abnormalities of coagulation tests and clinical coagulopathy. Hematology Am Soc Hematol Educ Program 2007; 179-186. Available at: http://www.hhs.gov/ash/bloodsafety/2009nbcus.pdf.
6. Vlaar APJ, In der Maur AL, Binnekade JM, et al.: A survey of physicians' reasons to transfuse plasma and platelets in the critically ill: a prospective single-centre cohort study. Transfus Med 2009; 19:207-212.
7. Abdel-Wahab OI, Healy B, Dzik WH: Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities. Transfusion 2006; 46:1279-1285.
8. Holland LL, Brooks JP: Toward rational fresh frozen plasma transfusion: the effect of plasma transfusion on coagulation test results. Am J Clin Pathol 2006; 126:133-139.
9. Grafstein E, Innes G: Guidelines for red blood cell and plasma transfusion for adults and children: an emergency physician's overview of the 1997 Canadian Blood Transfusion Guidelines. Part 2: Plasma transfusion and infectious risk. J Emerg Med 1997; 16:239-241.
10. Liumbruno G, Bennardello F, Lattanzio A, et al.: Recommendations for the transfusion of plasma and platelets. Blood Transfus 2009; 7:132-150.
11. O'Shaughnessy DF, Atterbury C, Bolton Maggs P, et al.: Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. Br J Haematol 2004; 126:11-28.
12. Pinkerton PH, Callum JL: Rationalizing the clinical use of frozen plasma. CMAJ 2010; 182:1019-1020.
13. Sarani B, Dunkman WJ, Dean L, et al.: Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med 2008; 36:1114-1118.
14. Church G, Matthay MA, Liu K, et al.: Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Pediatr Crit Care Med 2009; 10:297-302.
15. Watson GA, Sperry JL, Rosengart MR, et al.: Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma 2009; 67:221-227.
16. Pollack MM, Ruttimann UE, Getson PR: Pediatric risk of mortality (PRISM) score. Crit Care Med 1988; 16:1110-1116.
17. Goldstein B, Giroir B, Randolph A: International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6:2-8.
18. Lacroix J, Hébert PC, Hutchison JS, et al.: Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007; 356:1609-1619.
19. Bewick V, Cheek L, Ball J: Statistics review 14: logistic regression. Crit Care 2005; 9:112-118.
20. Dara SI, Rana R, Afessa B, et al.: Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med 2005; 33:2667-2671.
21. Khan H, Belsher J, Yilmaz M, et al.: Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 2007; 131:1308-1314.
22. Narick C, Triulzi DJ, Yazer MH: Transfusion-associated circulatory overload after plasma transfusion. Transfusion 2012; 52:160-165.
23. van Stein D, Beckers EA, Sintnicolaas K, et al.: Transfusion-related acute lung injury reports in the Netherlands: an observational study. Transfusion 2010; 50:213-220.
24. Nielsen HJ, Reimert C, Pedersen AN, et al.: Leucocyte-derived bioactive substances in fresh frozen plasma. Br J Anaesth 1997; 78:548-552.
25. European Committee on Blood Transfusion: Guide to the Preparation, Use and Quality Assurance of Blood Components, 16th edn. European Directorate for the Quality of Medicines & HealthCare (EDQM), Strasbourg, France, 2011.
26. Schneider SO, Rensing H, Gräber S, et al.: Impact of platelets and fresh frozen plasma in contrast to red cell concentrate on unstimulated and stimulated cytokine release in an in vitro model of transfusion. Scand J Immunol 2009; 70:101-105.
27. Nohé B, Kiefer RT, Ploppa A, et al.: The effects of fresh frozen plasma on neutrophil-endothelial interactions. Anesth Analg 2003; 97:216-221.
28. Horwitz RI, Feinstein AR: The problem of "protopathic bias" in case-control studies. Am J Med 1980; 68:255-258.
29. Nagelkerke NJD: A note on a general definition of the coefficient of determination. Biometrika 1991; 78:691-692.
30. Bateman ST, Lacroix J, Boven K, et al.: Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med 2008; 178:26-33.
31. Menon K, Ward RE, Lawson ML, et al.: A prospective multicenter study of adrenal function in critically ill children. Am J Respir Crit Care Med 2010; 182:246-251.
32. Jenkins K, Gauvreau K, Newburger J, et al.: Consensus-based method for risk adjustment for surgery for congenital heart disease. J Thorac Cardiovasc Surg 2002; 123:110-118.
33. Leteurtre S, Martinot A, Duhamel A, et al.: Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 2003; 362:192-197.