Circulating tumor cells as predictors of response and failure in breast cancer patients treated with preoperative chemotherapy

International Journal of Biological Markers

Volumn 28, Issue 1, 2013, Pages 17-23

  Boutrus, Rimoun R ^a   Raad, Rita F Abi ^a   Kuter, Irene ^a   Ancukiewicz, Marek ^a   Roberts, Lisa ^b   Solomon, Natalie ^b   Ngo, Taylor ^c   Borick, Heather ^c   Ryan, Paula ^a   Moy, Beverly ^a   Gadd, Michele ^a   Chien, Jo ^d   Younger, Jerry ^a   Smith, Barbara ^a   Taghian, Alphonse G ^a   Harris, Lyndsay ^e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Abbott Molecular Inc   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e YALE CANCER CENTER   (United States)

Author keywords

Breast cancer; Circulating tumor cells; Preoperative chemotherapy; Reverse transcription polymerase chain reaction

Indexed keywords

BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; BS 106; CYTOKERATIN 19; DOXORUBICIN; MESSENGER RNA; PACLITAXEL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CELL ISOLATION; CIRCULATING TUMOR CELL; DRUG DOSE SEQUENCE; ECHOMAMMOGRAPHY; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 2 CLINICAL TRIAL (TOPIC); PREOPERATIVE TREATMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT FAILURE; TREATMENT RESPONSE; TUMOR VOLUME;

ADULT; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CHEMOTHERAPY, ADJUVANT; FEMALE; HUMANS; KERATIN-19; MASTECTOMY; MIDDLE AGED; NEOPLASTIC CELLS, CIRCULATING; PROGNOSIS; SURVIVAL ANALYSIS; TREATMENT FAILURE; TUMOR MARKERS, BIOLOGICAL;

EID: 84876725295     PISSN: 03936155     EISSN: 17246008     Source Type: Journal    
DOI: 10.5301/JBM.2012.9580     Document Type: Article

References (33)

1. Stathopoulos E, Sanidas E, Kafousi M, et al. Detection of CK- 19 mRNApositive cells in the peripheral blood of breast cancer patients with histologically and immunohistochemically negative axillary lymph nodes. Ann Oncol 2005; 16: 240-6.
2. Ring A, Zabaglo L, Ormerod M, et al. Detection of circulating epithelial cells in the blood of patients with breast cancer: comparison of three techniques. Br J Cancer 2005; 92: 906-12.
3. Gilbey A, Burnett D, Coleman R, et al. The detection of circulating breast cancer cells. J Clin Pathol 2004; 57: 903-11.
4. Ring A, Smith I, Dowsett M. Circulating tumor cells in breast cancer. Lancet Oncol 2004; 5: 79-88.
5. Zach O and Lutz D. Tumor cell detection in peripheral blood and bone marrow. Curr Opin Oncol 2006; 18: 48-56.
6. Cristofanilli M, Budd G, Ellis M, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004; 351: 781-91.
7. Ellis M, Hayes DF, Lippman ME. Treatment of metastatic disease. In: Harris J, Lippman M, Morrow M, et al. Diseases of the breast. 3rd ed. Philadelphia: Lippincott- Raven; 2004: 1101-59.
8. Dawood S, Broglio K, Valero V, et al. Circulating tumor cells in metastatic breast cancer. From prognostic stratification to modification of the staging system? Cancer 2008; 113: 2422-30.
9. Cristofanilli M, Broglio K, Guarneri V, et al. Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden. Clin Breast Cancer 2007; 6: 471-9.
10. Buchholz T, Lehman C, Harris J, et al. Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: a National Cancer Institute conference. J Clin Oncol 2008; 26: 791-7.
11. Fisher B, Brown A, Mamounas E, et al. Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Oncol 1997; 15: 2483-93.
12. Weatherall P, Evans G, Metzger G, et al. MRI vs. histologic measurement of breast cancer following chemotherapy: comparison with x-ray mammography and palpation. J Magn Reson Imaging 2001; 13: 868-75.
13. Delille J, Slanetz P, Yeh E, et al. Invasive ductal breast carcinoma response to neoadjuvant chemotherapy: noninvasive monitoring with functional MR imaging-pilot study. Radiology 2003; 228: 63-9.
14. Segara D, Krop I, Garber J, et al. Does MRI predict pathologic tumor response in women with breast cancer undergoing preoperative chemotherapy? J Surg Oncol 2007; 96: 474-80.
15. Yeh E, Slanetz P, Kopans D et al. Prospective comparison of mammography, breast ultrasound and magnetic resonance imaging in patients undergoing neoadjuvant chemotherapy for palpable breast cancer. AJR Am J Roentgenol 2005; 184: 868-77.
16. Miksicek R, Myal Y, Watson P, Walker C, Murphy L and Leygue E. Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium. Cancer Res 2002; 62: 2736-40.
17. Bosma A, Weigelt B, Lambrechts A, et al. Detection of circulating breast tumor cells by differential expression of marker genes. Clin Cancer Res 2002; 8: 1871-7.
18. Noether, Gottfried E. Sample Size Determination for Some Common Nonparametric Tests. J Am Statistical Association 1987; 398: 645-7.
19. Pachmann K, Camara O, Kavallaris A, et al. Monitoring the response of circulating epithelial tumor cells to adjuvant chemotherapy in breast cancer allows detection of patients at risk of early relapse. J Clin Oncol 2008; 26: 1208-15.
20. Xenidis N, Markos V, Apostolaki S, et al. Clinical relevance of circulating CK-19 mRNA-positive cells detected during the adjuvant tamoxifen treatment in patients with early breast cancer. Ann Oncol 2007; 18: 1623-31.
21. Pierga JY, Bidard FC, Mathiot C, et al. Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase II randomized trial. Clin Cancer Res 2008; 14: 7004-10.
22. Pachmann K, Camara O, Kavallaris A, et al. Quantification of the response of circulating epithelial cells to neodadjuvant treatment for breast cancer: a new tool for therapy monitoring. Breast Cancer Research 2005; 7: R975-9.
23. Riethdorf S, Müller V, Zhang L et al. Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial. Clin Cancer Res 16; 2634-45.
24. Van der Auwera I, Peeters D, Benoy IH et al. Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT-PCR in patients with metastatic breast cancer. Br J Cancer 2010; 102: 276-84.
25. Biggers B, Knox S, Grant M, et al. Circulating tumor cells in patients undergoing surgery for primary breast cancer: preliminary results of a pilot study. Ann Surg Oncol 2009; 16: 969-71.
26. SUCCESS (www.success-studie.de
27. Stathopoulou A, Vlachonikolis I, Mavroudis D, et al. Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance. J Clin Oncol 2002; 20: 3404-12.
28. Iakovlev V, Goswami R, Vecchiarelli J, et al. Quantitative detection of circulating epithelial cells by Q-RT-PCR. Breast Cancer Res Treat 2008; 107: 145-54.
29. Pierga J, Bonneton C, Vincent-Salomon A, et al. Clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancer patients. Clin Cancer Res 2004; 10: 1392-1400.
30. Bidard F, Mathiot C, Delaloge S, et al. Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer. Ann Oncol 2010; 21: 729-33.
31. Krishnamurthy S, Cristofanilli M, Singh B, et al. Detection of minimal residual disease in blood and bone marrow in early stage breast cancer. Cancer 2010; 116: 3330-7.
32. Tse GM, Chaiwun B, Wong KT, et al. Magnetic resonance imaging of breast lesions-a pathologic correlation. Breast Cancer Res Treat 2007; 103: 1-10.
33. Knopp MV, Brix G, Junkermann HJ, et al. MR mammography with pharmacokinetic mapping for monitoring of breast cancer treatment during neoadjuvant therapy. Magn Reson Imaging Clin N Am 1994; 2: 633-58.