Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum

Molecular Microbiology

Volumn 88, Issue 4, 2013, Pages 702-712

  Heinberg, Adina ^a   Siu, Edwin ^b   Stern, Chaya ^a   Lawrence, Elizabeth A ^a   Ferdig, Michael T ^b   Deitsch, Kirk W ^a   Kirkman, Laura A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; CHLOROQUINE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FOLIC ACID; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; PYRIMETHAMINE; SULFADOXINE;

ALLELE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COPY NUMBER VARIATION; EVOLUTIONARY ADAPTATION; GENE AMPLIFICATION; GENE DUPLICATION; GENE OVEREXPRESSION; GTP CYCLOHYDROLASE 1 GENE; HAPLOTYPE; IC 50; NONHUMAN; PARASITE CULTIVATION; PARASITE SURVIVAL; PLASMODIUM FALCIPARUM; POINT MUTATION; PRIORITY JOURNAL; WILD TYPE;

ADAPTATION, BIOLOGICAL; ANTIMALARIALS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; GENE DOSAGE; GENES, PROTOZOAN; PLASMODIUM FALCIPARUM; PYRIMETHAMINE;

EID: 84876705818     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12162     Document Type: Article

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