A systematic review on preclinical and clinical studies on the use of scaffolds for bone repair in skeletal defects

Current Stem Cell Research and Therapy

Volumn 8, Issue 3, 2013, Pages 243-252

  Crowley, Conor ^a   Wong, James Min Leong ^a   Fisher, Daniel Mark ^a   Khan, Wasim S ^b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Bone regeneration; Bone repair; Mesenchymal stem cells; Musculoskeletal; Scaffolds; Tissue engineering

Indexed keywords

CALCIUM PHOSPHATE; COLLAGEN; HYALURONIC ACID; HYDROXYAPATITE; PHOSPHATIDYLSERINE; POLYCAPROLACTONE; SILICON; TISSUE SCAFFOLD;

ARTICLE; BONE DEFECT; BONE DEVELOPMENT; BONE GRAFT; BONE MINERALIZATION; BONE REGENERATION; BONE REMODELING; CERAMICS; COCHRANE LIBRARY; HUMAN; IN VIVO STUDY; MEDLINE; MESENCHYMAL STEM CELL; NONHUMAN; PATIENT SAFETY; PRIORITY JOURNAL; TISSUE ENGINEERING;

ANIMALS; BONE AND BONES; BONE TRANSPLANTATION; CLINICAL TRIALS AS TOPIC; HUMANS; TISSUE SCAFFOLDS; WOUND HEALING;

EID: 84876704993     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574888X11308030009     Document Type: Article

References (39)

1. Guo X, Zheng Q, Kulbatski I, et al. Bone regeneration with active angiogenesis by basic fibroblast growthfactor gene transfected mesenchymal stem cells seeded on porous β-TCP ceramic scaffolds. Biomed Mater 2006; 1(3): 93-9.
2. Pieske O, Wittmann A, Zaspel J, et al. Autologous bone graft versus demineralized bone matrix in internal fixation of ununited long bones. J Trauma Manag Outcomes 2009; 3: 11.
3. Nandi SK, Roy S, Mukherjee P, Kundu B, De DK, Basu D. Orthopaedic applications of bone graft & graft substitutes: a review. Indian J Med Res 2010; 132: 15-30.
4. Zhang ZY, Teoh SH, Chong MSK, et al. Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissueengineered bone grafts in critical-size femoral defects. Biomaterials 2010; 31: 608-20.
5. Kanakaris NK, Paliobeis C, Manidakis N, Giannoudis PV. Biological enhancement of tibial diaphyseal aseptic non-unions: the efficacy of autologous bone grafting BMPs and reaming by-products. Injury 2007; 38 (Suppl 2): S65-S75.
6. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF. Osteogenic Protein-1 (BMP-7) in the treatment of tibial nonunions. J Bone Joint Surg Am 2001; 83 (Suppl 1): S151-S158.
7. Schwartz CE, Martha JF, Kowalski P, et al. Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome. Health and Quality of Life Outcomes 2009; 7: 49.
8. Gupta AR, Shah NR, Patel TC, Grauer JR. Perioperative and longterm complications of iliac crest bone graft harvesting for spinal surgery: a quantitative review of the literature. Intern Med J 2001; 8 (3): 163-6.
9. Calori GM, Mazza E, Colombo M, Ripamonti C. The use of bonegraft substitutes in large bone defects: any specific needs? Injury 2011; 42 Suppl 2:S56-63.
10. Gamie Z, Tran GT, Vyzas G, Korres N, Heliotis M, Mantalaris A, Tsiridis E. Stem cells combined with bone graft substitutes in skeletal tissue engineering. Expert Opin Biol Ther 2012; 12(6): 713-29.
11. Mafi P, Hindocha S, Mafi R, Khan WS. Evaluation of biological protein-based collagen scaffolds in cartilage and musculoskeletal tissue engineering- A systematic Review of the Literature. Curr Stem Cell Res Ther 2012; 7(4): 302-9.
12. Boyan BD, Baker MI, Lee CSD, et al. Bone Tissue Grafting and Tissue Engineering Concepts. Comprehensive Biomaterials 2011; 6: 237-55.
13. Giannoudis PV, Dinopoulos H, Tsiridis E. Bone substitutes: An update. Injury 2005; 36S: S20-S27.
14. Viateau V, Guillemin G, Bousson V, et al. Long-Bone Critical-Size Defects Treated with Tissue-Engineered Grafts: A Study on Sheep. J Orthop Res 2007; 25(6): 741-9.
15. Zhu L, Liu W, Cui L, Cao Y. Tissue-engineered bone repair of goat-femur defects with osteogenically induced bone marrow stromal cells. Tissue Eng 2006; 12: 423-33.
16. Zhao M, Zhou J, Li X, Fang T, Dai W, Yin W, Dong J. Repair of bone defect with vascularized tissue engineered bone graft seeded with mesenchymal stem cells in rabbits. Microsurgery 2011; 31(2): 130-7.
17. Fan ZX, Lu Y, Deng L, et al. Placenta- versus bone-marrowderived mesenchymal cells for the repair of segmental bone defects in a rabbit model. FEBS Journal 2012; 279: 2455-65.
18. Li J, Han D, Sun H. Vascularization in transplantation of gene modified tissue engineered bone for repairing bone defect. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006 Sep;20(9):931-5.
19. Dong S, Ying D, Zhu C. Core-binding factor alpha1 gene modified marrow mesenchymal stem cells for repairing radial defects. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006; 20(5): 555-9.
20. Diab T, Pritchard EM, Uhrig BA, Boerckel JD, Kaplan DL, Guldberg RE. A silk hydrogel-based delivery system of bone morphogenetic protein for the treatment of large bone defects. J Mech Behav Biomed Mater 2012; 11: 123-31.
21. Hou J, Wang J, Cao L, et al. Segmental bone regeneration using rhBMP-2-loaded collagen/chitosan microspheres composite scaffold in a rabbit model. Biomed. Mater. 2012; 7(3): 035002.
22. Wang L, Fan H, Zhang ZY, et al. Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized b-tricalcium phosphate scaffold and mesenchymal stem cells. Biomaterials 2010; 31(36): 9452-61.
23. Cao L, Liu X, Liu S, Jiang Y, Zhang X, Zhang C, Zeng B. Experimental repair of segmental bone defects in rabbits by angiopoietin- 1 gene transfected MSCs seeded on porous b-TCP scaffolds. J Biomed Mater Res B Appl Biomater 2012; 100(5): 1229-36.
24. Rai B, Oest ME, Dupont KM, Ho KH, Teoh SH, Guldberg RE. Combination of platelet-rich plasma with polycaprolactonetricalcium phosphate scaffolds for segmental bone defect repair. J Biomed Mater Res A 2007; 81(4): 888-99.
25. Giannoni P, Mastrogiacomo M, Alini M, et al. Regeneration of large bone defects in sheep using bone marrow stromal cells. J Tissue Eng Regen Med 2008; 2: 253-262.
26. Bagher Z, Rajaei F, Shokrgozar M. Comparative Study of Bone Repair Using Porous Hydroxyapatite/β-Tricalcium Phosphate and Xenograft Scaffold in Rabbits with Tibia Defect. Iranian Biomedical Journal 2012; 16 (1): 18-24.
27. Arinzeh TL, Tran T, Mcalary J, Daculsi G. A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation. Biomaterials 2005; 26: 3631-8.
28. Choi HJ, Kim JM, Kwon E, et al. Establishment of Efficacy and Safety Assessment of Human Adipose Tissue-Derived Mesenchymal Stem Cells (hATMSCs) in a Nude Rat Femoral Segmental Defect Model. J Korean Med Sci 2011; 26: 482-91.
29. Kon E, Muraglia A, Corsi A, et al. Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. J Biomed Mater Res 2000; 49: 328-37.
30. Kasten P, Vogel J, Geiger F, Niemeyer P, Luginbühl R, Szalay K. The effect of platelet-rich plasma on healing in critical-size longbone defects. Biomaterials 2008; 29: 3983-92.
31. Xu C, Su P, Wang Y, et al. A novel biomimetic composite scaffold hybridized with mesenchymal stem cells in repair of rat bone defects models. J Biomed Mater Res A 2010; 95(2): 495-503.
32. Marcacci M, Kon E, Moukhachev V, et al. Stem cells associated with macroporous bioceramics for long bone repair: 6-to 7-year outcome of a pilot clinical study. Tissue Engineering 2007; 13(5): 947-55.
33. El-Adl G, Mostafa MF, Enan A, Ashraf M. Biphasic ceramic bone substitute mixed with autogenous bone marrow in the treatment of cavitary benign bone lesions. Acta orthopaedica belgica 2009; 75(1): 110-18.
34. Siegel HJ, Baird RC 3rd, Hall J, Lopez-Ben R, Lander PH. The outcome of composite bone graft substitute used to treat cavitary bone defects. Orthopedics 2008; 31(8): 754.
35. Morishita T, Honoki K, Ohgushi H, Kotobuki N, Matsushima A, Takakura Y. Tissue Engineering Approach to the Treatment of Bone Tumors: Three Cases of Cultured Bone Grafts Derived From Patients Mesenchymal Stem Cells. Artificial Organs 30(2): 115-21.
36. Quarto R, Mastrogiacomo M, Cancedda R, et al. Repair of large bone defects with the use of autologous bone marrow stromal cells. The New England Journal Of Medicine 2001; 344(5): 385-6.
37. Herberts CA, Kwa MS, Hermsen HP. Risk factors in the development of stem cell therapy. J Transl Med 2011; 9: 29.
38. Carson JS, Bostrom MP. Synthetic bone scaffolds and fracture repair. Injury 2007; 38 Suppl 1: S33-7.
39. Juni P, Holenstein F, Sterne J, Bartlett C, Egger M. Direction and impact of language bias in meta-analyses of controlled trials: empirical study. Int J Epidemiol 2002; 31: 115-23.