Reciprocal regulation of the autophosphorylation of enzyme INtr by glutamine and α-ketoglutarate in Escherichia coli

Molecular Microbiology

Volumn 88, Issue 3, 2013, Pages 473-485

  Lee, Chang Ro ^a,b   Park, Young Ha ^a   Kim, Miri ^a   Kim, Yeon Ran ^a   Park, Soyoung ^a   Peterkofsky, Alan ^c   Seok, Yeong Jae ^a  

^a Seoul National University   (South Korea)

^b Myong Ji University   (South Korea)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; BACTERIAL ENZYME; GLUTAMINE; NITROGEN PHOSPHOTRANSFERASE; PHOSPHOENOLPYRUVATE; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ESCHERICHIA COLI; MOUSE; NITROGEN AVAILABILITY; NITROGEN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEOBACTERIA; SIGNAL TRANSDUCTION;

ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GLUTAMINE; KETOGLUTARIC ACIDS; NITROGEN; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE SYSTEM; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PLASMIDS; PROTEIN ENGINEERING;

ESCHERICHIA COLI; PROTEOBACTERIA;

EID: 84876703328     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12196     Document Type: Article

References (50)

1. Bahr, T., Lüttmann, D., März, W., Rak, B., and Görke, B. (2011) Insight into bacterial phosphotransferase system-mediated signaling by interspecies transplantation of a transcriptional regulator. J Bacteriol 193: 2013-2026.
2. Blattner, F.R., Plunkett, G., 3rd, Bloch, C.A., Perna, N.T., Burland, V., Riley, M., etal. (1997) The complete genome sequence of Escherichia coli K-12. Science 277: 1453-1462.
3. Cases, I., Velázquez, F., and de Lorenzo, V. (2001) Role of ptsO in carbon-mediated inhibition of the Pu promoter belonging to the pWW0 Pseudomonas putida plasmid. J Bacteriol 183: 5128-5133.
4. Ntr-SsrB interaction is required for Salmonella virulence. Proc Natl Acad Sci USA 107: 20506-20511.
5. Datsenko, K.A., and Wanner, B.L. (2000) One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA 97: 6640-6645.
6. Deutscher, J., Francke, C., and Postma, P.W. (2006) How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria. Microbiol Mol Biol Rev 70: 939-1031.
7. Doucette, C.D., Schwab, D.J., Wingreen, N.S., and Rabinowitz, J.D. (2011) α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nat Chem Biol 7: 894-901.
8. Gollop, N., Tavori, H., and Barak, Z. (1982) Acetohydroxy acid synthase is a target for leucine containing peptide toxicity in Escherichia coli. J Bacteriol 149: 387-390.
9. Higa, F., and Edelstein, P.H. (2001) Potential virulence role of the Legionella pneumophila ptsP ortholog. Infect Immun 69: 4782-4789.
10. Hogema, B.M., Arents, J.C., Bader, R., Eijkemans, K., Inada, T., Aiba, H., and Postma, P.W. (1998) Inducer exclusion by glucose 6-phosphate in Escherichia coli. Mol Microbiol 28: 755-765.
11. Jiang, P., Peliska, J.A., and Ninfa, A.J. (1998) Enzymological characterization of the signal-transducing uridylyltransferase/uridylyl-removing enzyme (EC 2.7.7.59) of Escherichia coli and its interaction with the PII protein. Biochemistry 37: 12782-12794.
12. Jiang, P., Mayo, A.E., and Ninfa, A.J. (2007) Escherichia coli glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49): kinetic characterization of regulation by PII, PII-UMP, glutamine, and α-ketoglutarate. Biochemistry 46: 4133-4146.
13. Kamberov, E.S., Atkinson, M.R., and Ninfa, A.J. (1995) The Escherichia coli PII signal transduction protein is activated upon binding 2-ketoglutarate and ATP. J Biol Chem 270: 17797-17807.
14. Kim, H.J., Lee, C.R., Kim, M., Peterkofsky, A., and Seok, Y.J. (2011) Dephosphorylated NPr of the nitrogen PTS regulates lipid A biosynthesis by direct interaction with LpxD. Biochem Biophys Res Commun 409: 556-561.
15. Glc in Escherichia coli. J Biol Chem 279: 31613-31621.
16. LaVallie, E.R., DiBlasio, E.A., Kovacic, S., Grant, K.L., Schendel, P.F., and McCoy, J.M. (1993) A thioredoxin gene fusion expression system that circumvents inclusion body formation in the E. coli cytoplasm. Biotechnology (N Y) 11: 187-193.
17. Lawther, R.P., Calhoun, D.H., Adams, C.W., Hauser, C.A., Gray, J., and Hatfield, G.W. (1981) Molecular basis of valine resistance in Escherichia coli K-12. Proc Natl Acad Sci USA 78: 922-925.
18. Ntr for derepression of Escherichia coli K-12 ilvBN expression. Mol Microbiol 58: 334-344.
19. + transporter TrkA. Proc Natl Acad Sci USA 104: 4124-4129.
20. Ntr-dependent regulation of sigma factor selectivity. Mol Microbiol 78: 1468-1483.
21. 2+ site in the Bacillus subtilis peroxide sensor PerR. J Biol Chem 281: 23567-23578.
22. Lee, K.J., Jeong, C.S., An, Y.J., Lee, H.J., Park, S.J., Seok, Y.J., etal. (2011) FrsA functions as a cofactor-independent decarboxylase to control metabolic flux. Nat Chem Biol 7: 434-436.
23. Lee, S.J., Boos, W., Bouche, J.P., and Plumbridge, J. (2000) Signal transduction between a membrane-bound transporter, PtsG, and a soluble transcription factor, Mlc, of Escherichia coli. EMBO J 19: 5353-5361.
24. Little, R., and Dixon, R. (2003) The amino-terminal GAF domain of Azotobacter vinelandii NifA binds 2-oxoglutarate to resist inhibition by NifL under nitrogen-limiting conditions. J Biol Chem 278: 28711-28718.
25. Ntr in Escherichia coli. Mol Microbiol 72: 978-994.
26. Ntr modulates the phosphate starvation response through interaction with histidine kinase PhoR in Escherichia coli. Mol Microbiol 86: 96-110.
27. Lux, R., Jahreis, K., Bettenbrock, K., Parkinson, J.S., and Lengeler, J.W. (1995) Coupling the phosphotransferase system and the methyl-accepting chemotaxis protein-dependent chemotaxis signaling pathways of Escherichia coli. Proc Natl Acad Sci USA 92: 11583-11587.
28. Michiels, J., Van Soom, T., D'Hooghe, I., Dombrecht, B., Benhassine, T., de Wilde, P., and Vanderleyden, J. (1998) The Rhizobium etli rpoN locus: DNA sequence analysis and phenotypical characterization of rpoN, ptsN, and ptsA mutants. J Bacteriol 180: 1729-1740.
29. Glc recruits the global repressor Mlc. EMBO J 20: 491-498.
30. Nam, T.W., Park, Y.H., Jeong, H.J., Ryu, S., and Seok, Y.J. (2005) Glucose repression of the Escherichia coli sdhCDAB operon, revisited: regulation by the CRP*cAMP complex. Nucleic Acids Res 33: 6712-6722.
31. Ninfa, A.J. (2011) Unnecessary signaling: poorly named? J Bacteriol 193: 4571-4573.
32. Ninfa, A.J., and Atkinson, M.R. (2000) PII signal transduction proteins. Trends Microbiol 8: 172-179.
33. Ninfa, A.J., and Jiang, P. (2005) PII signal transduction proteins: sensors of α-ketoglutarate that regulate nitrogen metabolism. Curr Opin Microbiol 8: 168-173.
34. Park, Y.H., Lee, B.R., Seok, Y.J., and Peterkofsky, A. (2006) In vitro reconstitution of catabolite repression in Escherichia coli. J Biol Chem 281: 6448-6454.
35. Peterkofsky, A., Wang, G., and Seok, Y.J. (2006) Parallel PTS systems. Arch Biochem Biophys 453: 101-107.
36. Ntr) protein of Pseudomonas putida. J Biol Chem 282: 18206-18211.
37. Pflüger-Grau, K., and Görke, B. (2010) Regulatory roles of the bacterial nitrogen-related phosphotransferase system. Trends Microbiol 18: 205-214.
38. Ntr alters its stability. Arch Biochem Biophys 507: 332-342.
39. ts mutant. J Biol Chem 270: 4822-4839.
40. Ntr system globally regulates ATP-dependent transporters in Rhizobium leguminosarum. Mol Microbiol 84: 117-129.
41. Ntr from Escherichia coli. A novel enzyme of the phosphoenolpyruvate-dependent phosphotransferase system exhibiting strict specificity for its phosphoryl acceptor, NPr. J Biol Chem 274: 26185-26191.
42. Reaves, M.L., and Rabinowitz, J.D. (2011) Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG. J Bacteriol 193: 4576-4581.
43. Reddy, P., Peterkofsky, A., and McKenney, K. (1989) Hyperexpression and purification of Escherichia coli adenylate cyclase using a vector designed for expression of lethal gene products. Nucleic Acids Res 17: 10473-10488.
44. Reizer, J., Reizer, A., Merrick, M.J., Plunkett, G., 3rd, Rose, D.J., and Saier, M.H., Jr. (1996) Novel phosphotransferase-encoding genes revealed by analysis of the Escherichia coli genome: a chimeric gene encoding an Enzyme I homologue that possesses a putative sensory transduction domain. Gene 181: 103-108.
45. Segura, D., and Espin, G. (1998) Mutational inactivation of a gene homologous to Escherichia coli ptsP affects poly-β-hydroxybutyrate accumulation and nitrogen fixation in Azotobacter vinelandii. J Bacteriol 180: 4790-4798.
46. Senior, P.J. (1975) Regulation of nitrogen metabolism in Escherichia coli and Klebsiella aerogenes: studies with the continuous-culture technique. J Bacteriol 123: 407-418.
47. Seok, Y.J., Sondej, M., Badawi, P., Lewis, M.S., Briggs, M.C., Jaffe, H., and Peterkofsky, A. (1997) High affinity binding and allosteric regulation of Escherichia coli glycogen phosphorylase by the histidine phosphocarrier protein, HPr. J Biol Chem 272: 26511-26521.
48. Tanaka, Y., Kimata, K., and Aiba, H. (2000) A novel regulatory role of glucose transporter of Escherichia coli: membrane sequestration of a global repressor Mlc. EMBO J 19: 5344-5352.
49. Zhang, S., Chen, Y., Potvin, E., Sanschagrin, F., Levesque, R.C., McCormack, F.X., and Lau, G.W. (2005) Comparative signature-tagged mutagenesis identifies Pseudomonas factors conferring resistance to the pulmonary collectin SP-A. PLoS Pathog 1: 259-268.
50. Zhou, X.M., Liu, Y., Payne, G., Lutz, R.J., and Chittenden, T. (2000) Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J Biol Chem 275: 25046-25051.