Esophageal chemical clearance is impaired in gastro-esophageal reflux disease - a 24-h impedance-pH monitoring assessment

Neurogastroenterology and Motility

Volumn 25, Issue 5, 2013, Pages

  Frazzoni, M ^a   Manta, R ^a   Mirante, V G ^a   Conigliaro, R ^a   Frazzoni, L ^a   Melotti, G ^a  

^a Nuovo Ospedale S Agostino   (Italy)

Author keywords

Esophageal clearance; Functional heartburn; Impedance pH monitoring; Refractory gastro esophageal reflux disease

Indexed keywords

ANTIREFLUX OPERATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ESOPHAGUS MOTILITY; FOLLOW UP; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL TRANSIT; HEARTBURN; HIATUS HERNIA; HUMAN; PERISTALSIS; PH MEASUREMENT; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; REMISSION; RETROSPECTIVE STUDY;

ELECTRIC IMPEDANCE; ESOPHAGEAL PH MONITORING; ESOPHAGUS; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; PERISTALSIS; RETROSPECTIVE STUDIES;

EID: 84876696680     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12080     Document Type: Article

References (38)

1. Kahrilas PJ, Shaheen NJ, Vaezi MF. American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease. Gastroenterology 2008; 135: 1383-91.
2. Scarpignato C. Poor effectiveness of proton pump inhibitors in non-erosive reflux disease: the truth in the end. Neurogastroenterol Motil 2012; 24: 697-704.
3. Sifrim D, Zerbib F. Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors. Gut 2012; 61: 1340-54.
4. Mainie I, Tutuian R, Shay S et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicenter study using combined ambulatory impedance-pH monitoring. Gut 2006; 55: 1398-402.
5. Dellon ES, Shaheen NJ. Persistent reflux symptoms in the proton pump inhibitor era: the changing face of gastroesophageal reflux disease. Gastroenterology 2010; 139: 7-13.
6. Hershcovici T, Fass R. Nonerosive reflux disease (NERD) - an update. J Neurogastroenterol Motil 2010; 16: 8-21.
7. Kahrilas PJ, Smout AJPM. Esophageal disorders. Am J Gastroenterol 2010; 105: 747-56.
8. Blondeau K, Tack J. Usefulness of impedance testing in the management of GERD. Am J Gastroenterol 2009; 104: 2664-6.
9. Frazzoni M, Conigliaro R, Mirante VG, Melotti G. The added value of quantitative analysis of on-therapy impedance-pH parameters in distinguishing refractory non-erosive reflux disease from functional heartburn. Neurogastroenterol Motil 2012; 24: 141-e87.
10. Boeckxstaens GE. Review article: the pathophysiology of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2007; 26: 149-60.
11. Helm JF, Dodds WJ, Pelc LR, Palmer DW, Hogan WJ, Teeter BC. Effect of esophageal emptying and saliva on clearance of acid from the esophagus. N Engl J Med 1984; 310: 284-8.
12. Shafik A, El-Sibai O, Shafik AA, Mostafa R. Effect of topical esophageal acidification on salivary secretion: identification of the mechanism of action. J Gastroenterol Hepatol 2005; 20: 1935-9.
13. Korsten MA, Rosman AS, Fishbein S, Shlein RD, Goldberg HE, Biener A. Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury. Am J Med 1991; 90: 701-6.
14. Frazzoni M, De Micheli E, Zentilin P, Savarino V. Pathophysiological characteristics of patients with non-erosive reflux disease differ from those of patients with functional heartburn. Aliment Pharmacol Ther 2004; 20: 81-8.
15. Bredenoord AG, Tutuian R, Smout AJPM, Castell DO. Technology review: esophageal impedance monitoring. Am J Gastroenterol 2006; 101: 1-8.
16. Conchillo JM, Smout AJ. Review article: intra-oesophageal impedance monitoring for the assessment of bolus transit and gastro-oesophageal reflux. Aliment Pharmacol Ther 2008; 29: 3-14.
17. Woodley FW, Fernandez F, Mousa H. Diurnal variation in the chemical clearance of acid gastroesophageal reflux in infants. Clin Gastroenterol Hepatol 2007; 5: 37-43.
18. Frazzoni M, Conigliaro R, Melotti G. Weakly acidic refluxes have a major role in the pathogenesis of proton pump inhibitor-resistant reflux oesophagitis. Aliment Pharmacol Ther 2011; 33: 601-6.
19. Frazzoni M, Grisendi A, Lanzani A, Melotti G, De Micheli E. Laparoscopic fundoplication versus lansoprazole for gastro-oesophageal reflux disease. A pH-metric comparison. Dig Liver Dis 2002; 34: 99-104.
20. Lundell LR, Dent J, Bennett JR et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999; 45: 172-80.
21. Nguyen NQ, Tippet M, Smout AJPM, Holloway RH. Relationship between pressure wave amplitude and esophageal bolus clearance assessed by combined manometry and multichannel intraluminal impedance measurement. Am J Gastroenterol 2006; 101: 2476-84.
22. Blonski W, Vela M, Safder A, Hila A, Castell DO. Revised criterion for diagnosis of ineffective esophageal motility is associated with more frequent dysphagia and greater bolus transit abnormalities. Am J Gastroenterol 2008; 103: 699-704.
23. Frazzoni M, Savarino E, Manno M et al. Reflux patterns in patients with short segment Barrett's oesophagus: a study using impedance-pH monitoring off and on proton pump inhibitor therapy. Aliment Pharmacol Ther 2009; 30: 508-15.
24. Sifrim D, Castell D, Dent J, Kahrilas PJ. Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 2004; 53: 1024-31.
25. Zerbib F, Roman S, Ropert A et al. Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol 2006; 101: 1956-63.
26. Tutuian R, Vela MF, Balaji NS et al. Esophageal function testing with combined multichannel intraluminal impedance and manometry: multicenter study in healthy volunteers. Clin Gastroenterol Hepatol 2003; 1: 174-82.
27. Bredenoord AJ, Weusten BLAM, Timmer R, Smout AJPM. Reproducibility of multichannel intraluminal electrical impedance monitoring of gastroesophageal reflux. Am J Gastroenterol 2005; 100: 265-9.
28. Simrén M, Silny J, Holloway R, Tack J, Janssens J, Sifrim D. Relevance of ineffective oesophageal motility during oesophageal acid clearance. Gut 2003; 52: 784-90.
29. Tutuian R, Castell DO. Combined multichannel intraluminal impedance and manometry clarifies esophageal function abnormalities: study in 350 patients. Am J Gastroenterol 2004; 99: 1011-9.
30. Bogte A, Bredenoord AJ, Oors J, Siersema PD, Smout AJPM. Relationship between esophageal contraction patterns and clearance of swallowed liquid and solid boluses in healthy controls and patients with dysphagia. Neurogastroenterol Motil 2012; 24: e364-72.
31. Fibbe C, Layer P, Keller J, Strate U, Emmermann A, Zornig C. Esophageal motility in reflux disease before and after fundoplication: a prospective, randomized, clinical, and manometric study. Gastroenterology 2001; 121: 5-14.
32. Bredenoord AJ. Mechanisms of reflux perception in gastroesophageal reflux disease: a review. Am J Gastroenterol 2012; 107: 8-15.
33. Spechler JS. Surgery for gastroesophageal reflux disease: esophageal impedance to progress? Clin Gastroenterol Hepatol 2009; 7: 1264-5.
34. Zerbib F, Belhocine K, Simon M et al. Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastroesophageal reflux disease. Gut 2012; 61: 501-6.
35. Slaughter JC, Goutte M, Rymer JA et al. Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2011; 9: 868-74.
36. Pritchett JM, Aslam M, Slaughter JC, Ness RM, Garrett CG, Vaezi MF. Efficacy of esophageal impedance/pH monitoring in patients with refractory gastroesophageal reflux disease, on and off therapy. Clin Gastroenterol Hepatol 2009; 7: 743-8.
37. Frazzoni M, Conigliaro R, Melotti G. Reflux parameters as modified by laparoscopic fundoplication in 40 patients with heartburn/regurgitation persisting despite PPI therapy. A study using impedance-pH monitoring. Dig Dis Sci 2011; 56: 1099-106.
38. Frazzoni M, Conigliaro R, Colli G, Melotti G. Conventional versus robot-assisted laparoscopic Nissen fundoplication. A comparison of postoperative acid reflux parameters. Surg Endosc 2012; 26: 1675-81.