Localization and signaling patterns of vascular endothelial growth factors and receptors in human periapical lesions

Journal of Endodontics

Volumn 39, Issue 5, 2013, Pages 605-611

  Virtej, Anca ^a   Løes, Sigbjørn S ^a,b   Berggreen, Ellen ^a   Bletsa, Athanasia ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Apical periodontitis; immune cells; immunohistochemistry; vascularity

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE; PROTEIN KINASE C; VASCULOTROPIN A; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; VEGFA PROTEIN, HUMAN; VEGFR3 PROTEIN, HUMAN;

ALVEOLAR BONE LOSS; ARTICLE; B LYMPHOCYTE; BLOOD VESSEL; COMPARATIVE STUDY; DISEASE COURSE; HUMAN; LYMPHOCYTE; MACROPHAGE; NECROSIS; NEOVASCULARIZATION (PATHOLOGY); NEUTROPHIL; PATHOLOGY; PERIODONTAL LIGAMENT; PHYSIOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TOOTH PERIAPICAL DISEASE; UPREGULATION;

ALVEOLAR BONE LOSS; B-LYMPHOCYTES; BLOOD VESSELS; DISEASE PROGRESSION; HUMANS; LYMPHOCYTES; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASES; NECROSIS; NEOVASCULARIZATION, PATHOLOGIC; NEUTROPHILS; PERIAPICAL PERIODONTITIS; PERIODONTAL LIGAMENT; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOLIPASES; PROTEIN KINASE C; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 84876690421     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joen.2012.12.017     Document Type: Article

References (43)

1. P. Stashenko, R. Teles, and R. D'Souza Periapical inflammatory responses and their modulation Crit Rev Oral Biol Med 9 1998 498 521 (Pubitemid 29402013)
2. D.T. Graves, T. Oates, and G.P. Garlet Review of osteoimmunology and the host response in endodontic and periodontal lesions J Oral Microbiol 3 2011 5304 5318
3. S. Liapatas, M. Nakou, and D. Rontogianni Inflammatory infiltrate of chronic periradicular lesions: an immunohistochemical study Int Endod J 36 2003 464 471 (Pubitemid 37249057)
4. A. Lukic, N. Arsenijevic, and G. Vujanic Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions J Endod 16 1990 119 122
5. N. Kawashima, N. Suzuki, and G. Yang Kinetics of RANKL, RANK and OPG expressions in experimentally induced rat periapical lesions Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 2007 707 711
6. R. Menezes, T.P. Garlet, and A. Letra Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions J Endod 34 2008 932 938
7. C. Halin, and M. Detmar Chapter 1: inflammation, angiogenesis, and lymphangiogenesis Methods Enzymol 445 2008 1 25
8. J.A. Nagy, L. Benjamin, and H. Zeng Vascular permeability, vascular hyperpermeability and angiogenesis Angiogenesis 11 2008 109 119
9. T. Tammela, and K. Alitalo Lymphangiogenesis: molecular mechanisms and future promise Cell 140 2010 460 476
10. Y. Huang, X. Chen, and M.M. Dikov Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF Blood 110 2007 624 631 (Pubitemid 47105401)
11. O.I. Stepanova, A.V. Krylov, and V.I. Lioudyno Gene expression for VEGF-A, VEGF-C, and their receptors in murine lymphocytes and macrophages Biochemistry (Mosc) 72 2007 1194 1198 (Pubitemid 350171971)
12. S.F. Schoppmann, P. Birner, and J. Stockl Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis Am J Pathol 161 2002 947 956 (Pubitemid 34988382)
13. D. Gabrilovich, T. Ishida, and T. Oyama Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo Blood 92 1998 4150 4166 (Pubitemid 28544331)
14. R. Bohmer, B. Neuhaus, and S. Buhren Regulation of developmental lymphangiogenesis by Syk(+) leukocytes Dev Cell 18 2010 437 449
15. S.E. Aldridge, T.W. Lennard, and J.R. Williams Vascular endothelial growth factor receptors in osteoclast differentiation and function Biochem Biophys Res Commun 335 2005 793 798 (Pubitemid 41188268)
16. Y.S. Hah, J.S. Jun, and S.G. Lee Vascular endothelial growth factor stimulates osteoblastic differentiation of cultured human periosteal-derived cells expressing vascular endothelial growth factor receptors Mol Biol Rep 38 2011 1443 1450
17. D.M. Sosnoski, V. Krishnan, and W.J. Kraemer Changes in cytokines of the bone microenvironment during breast cancer metastasis Int J Breast Cancer 2012 2012 160265 10.1155/2012/160265 Epub 2012 Jan 23
18. A. Bletsa, A. Virtej, and E. Berggreen Vascular endothelial growth factors and receptors are up-regulated during development of apical periodontitis J Endod 38 2012 628 635
19. I.J. Marton, and C. Kiss Protective and destructive immune reactions in apical periodontitis Oral Microbiol Immunol 15 2000 139 150 (Pubitemid 30208575)
20. R. Leonardi, M. Caltabiano, and M. Pagano Detection of vascular endothelial growth factor/vascular permeability factor in periapical lesions J Endod 29 2003 180 183 (Pubitemid 43210846)
21. C.F. Nonaka, A.P. Maia, and G.J. Nascimento Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 2008 896 902
22. G.P. Garlet, R. Horwat, and H.L. Ray Jr. Expression analysis of wound healing genes in human periapical granulomas of progressive and stable nature J Endod 38 2012 185 190
23. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
24. A. Bletsa, I. Fristad, and E. Berggreen Sensory pulpal nerve fibres and trigeminal ganglion neurons express IL-1RI: a potential mechanism for development of inflammatory hyperalgesia Int Endod J 42 2009 978 986
25. A. Piattelli, L. Artese, and S. Rosini Immune cells in periapical granuloma: morphological and immunohistochemical characterization J Endod 17 1991 26 29
26. Z. Metzger Macrophages in periapical lesions Endod Dent Traumatol 16 2000 1 8
27. S. Koch, S. Tugues, and X. Li Signal transduction by vascular endothelial growth factor receptors Biochem J 437 2011 169 183
28. A. Eichmann, and M. Simons VEGF signaling inside vascular endothelial cells and beyond Curr Opin Cell Biol 24 2012 188 193
29. Q. Zhang, D. Wang, and V. Kundumani-Sridharan PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic retinal neovascularization Blood 116 2010 1377 1385
30. T. Takahashi, S. Yamaguchi, and K. Chida A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells Embo J 20 2001 2768 2778 (Pubitemid 32938560)
31. Q. Zhang, D. Wang, and N.K. Singh Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-protein kinase C gamma (PKCgamma) signaling axis is required for hypoxia-induced pathological retinal angiogenesis J Biol Chem 286 2011 22489 22498
32. T. Makinen, T. Veikkola, and S. Mustjoki Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3 Embo J 20 2001 4762 4773 (Pubitemid 32848629)
33. A. Salameh, F. Galvagni, and M. Bardelli Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways Blood 106 2005 3423 3431 (Pubitemid 41609177)
34. K.E. Ratcliffe, Q. Tao, and B. Yavuz Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling Oncogene 21 2002 6307 6316
35. H.K. Wong, A. Shimizu, and N.D. Kirkpatrick Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism Neoplasia 14 2012 84 94
36. M.T. Kearns, S. Dalal, and S.A. Horstmann Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells Am J Physiol Lung Cell Mol Physiol 302 2012 L711 L718
37. Y.S. Kim, S.J. Choi, and Y.M. Tae Distinct roles of vascular endothelial growth factor receptor-1- and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung J Immunol 185 2010 5648 5655
38. Y. Wu, and Z. Zhu Vascular endothelial growth factor receptor 1, a therapeutic target in cancer, inflammation and other disorders Curr Med Chem 16 2009 2890 2898
39. S. Laxmanan, S.W. Robertson, and E. Wang Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways Biochem Biophys Res Commun 334 2005 193 198 (Pubitemid 40978525)
40. E. Gerasimovskaya, A. Kratzer, and A. Sidiakova Interplay of macrophages and T cells in the lung vasculature Am J Physiol Lung Cell Mol Physiol 302 2012 L1014 L1022
41. R. Gerli, I. Secciani, and F. Sozio Absence of lymphatic vessels in human dental pulp: a morphological study Eur J Oral Sci 118 2010 110 117
42. K. Maruyama, M. Ii, and C. Cursiefen Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages J Clin Invest 115 2005 2363 2372 (Pubitemid 41266198)
43. K. Schledzewski, M. Falkowski, and G. Moldenhauer Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis J Pathol 209 2006 67 77