Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-Protein kinase C γ (PKCγ) signaling axis is required for hypoxia-induced pathological retinal angiogenesis

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22489-22498

  Zhang, Qiuhua ^a   Wang, Dong ^a   Singh, Nikhlesh K ^a   Kundumani Sridharan, Venkatesh ^a   Gadiparthi, Laxmisilpa ^a   Rao, Ch Mohan ^b   Rao, Gadiparthi N ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ARACHIDONIC ACIDS; CYTOSOLIC PHOSPHOLIPASE; DNA SYNTHESISS; DOWN-REGULATION; MICROVASCULAR ENDOTHELIAL CELLS; MOUSE MODELS; NEOVASCULARIZATION; PROTEIN KINASE C; TIME-DEPENDENT; TUBE FORMATION; VASCULAR ENDOTHELIAL GROWTH FACTOR;

CELL PROLIFERATION; ENDOTHELIAL CELLS; MAMMALS; PHOSPHORYLATION; SIGNALING;

OPHTHALMOLOGY;

ARACHIDONIC ACID; CYTOSOLIC PHOSPHOLIPASE A2; DNA; PHOSPHOLIPASE D1; PROTEIN KINASE C GAMMA; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HYPOXIA; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINA NEOVASCULARIZATION; SIGNAL TRANSDUCTION;

ANIMALS; ANOXIA; ARACHIDONIC ACID; CELL MOVEMENT; DNA; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; MICE; NEOVASCULARIZATION, PATHOLOGIC; OXYGEN; PHOSPHOLIPASE D; PHOSPHOLIPASES A2, CYTOSOLIC; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RETINA; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79959358969     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.217786     Document Type: Article

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