Design and synthesis of novel antifungal triazole derivatives with good activity and water solubility

Chinese Chemical Letters

Volumn 24, Issue 4, 2013, Pages 303-306

  Cao, Xu Feng ^a   Chu, Wen Jing ^a   Cao, Yong Bing ^b   Yang, Yu She ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal; SYN 2869 analogues; Synthesis; Triazole; Water solubility

Indexed keywords

EID: 84876686170     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2013.01.047     Document Type: Article

References (16)

1. L.A. Sorbera, J. Aravamudan, and E. Rosa Therapeutic target for candidiasis Drugs Future 36 2011 627 630
2. L.H. Zhu, D.D. Li, Y. Wang, and Y.Y. Jiang Novel thoughts on treatment of invasive fungal infections Dier Junyi Daxue Xuebao 33 2012 558 561 (in Chinese)
3. A. Jain, S. Jain, and S. Rawat Emerging fungal infections among children: a review on its clinical manifestations, diagnosis, and prevention J. Pharm. Bioallied Sci. 2 2010 314 320
4. S. Tobudic, C. Kratzer, and E. Presterl Azole-resistant Candida spp.-emerging pathogens? Mycoses 55 2012 24 32
5. T. Naito, K. Hata, and A. Tsuruoka ER-30346. Triazole antifungal Drugs Future 21 1996 20 24
6. I. Hadrich, F. Makni, and S. Neji Invasive aspergillosis: resistance to antifungal drugs Mycopathologia 174 2012 131 141
7. K. Wan, Y. Zhang, and C. Zhou Recent advances in antifungal fluconazole Zhongguo Kangshengsu Zazhi 37 8-15 2012 20 (in Chinese)
8. J.C.R. Corrêa, and H.R.N. Salgado Review of fluconazole properties and analytical methods for its determination Crit. Rev. Anal. Chem. 41 2011 124 132
9. Z.G. Dan, J. Zhang, and S.C. Yu Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase (CYP51) Chin. Chem. Lett. 20 2009 935 938
10. G. Kofla, and M. Ruhnke Voriconazole: review of a broad spectrum triazole antifungal agent Expert Opin. Pharmacother. 6 2005 1215 1229
11. Y. Liu, Z.N. Liu, and X.F. Cao Design and synthesis of pyridine-substituted itraconazole analogues with improved antifungal activities, water solubility and bioavailability Bioorg. Med. Chem. Lett. 21 2011 4779 4783
12. R.A. Fromtling, and J. Castaner Syn-2869: antifungal Drugs Future 24 1999 30 37
13. E.M. Johnson, A. Szekely, and D.W. Warnock In vitro activity of Syn-2869, a novel triazole agent, against emerging and less common mold pathogens Antimicrob. Agents Chemother. 43 1999 1260 1263
14. H. Ogura, H. Kobayashi, and K. Nagai Synthesis and antifungal activities of (2R, 3R)-2-aryl-1-azolyl-3-(substituted amino)-2-butanol derivatives as topical antifungal agents Chem. Pharm. Bull. 47 1999 1417 1425
15. J. Pesti, C.K. Chen, and L. Spangler The process development of ravuconazole: an efficient multikilogram scale preparation of an antifungal agent (1) Org. Process. Res. Dev. 13 2009 716 728
16. Clinical and Laboratory Standards Institute/National Committee for Clinical Laboratory Standards: Reference method for broth dilution antifungal susceptibility testing of Yeast, Approved Standard, 3rd ed., Document M27-A3. Wayne, PA, Clinical and Laboratory Standards Institute, 2009.