Design and synthesis of pyridine-substituted itraconazole analogues with improved antifungal activities, water solubility and bioavailability

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4779-4783

  Liu, Yu ^a   Liu, Zining ^a   Cao, Xufeng ^a   Liu, Xin ^a   He, Huili ^a   Yang, Yushe ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antifungal; Bioavailability; Itraconazole analogues; Synthesis

Indexed keywords

ITRACONAZOLE; PYRIDINE; TRIAZOLE DERIVATIVE;

AMES TEST; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; GENETIC TOXICOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; SUBSTITUTION REACTION;

ANIMALS; ANTIFUNGAL AGENTS; BIOLOGICAL AVAILABILITY; DRUG DESIGN; FUNGI; ITRACONAZOLE; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIDINES; RATS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

FUNGI;

EID: 79960915959     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.062     Document Type: Article

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