ER-30346. Triazole antifungal

Drugs of the Future

Volumn 21, Issue 1, 1996, Pages 20-24

  Naito, Toshihiko ^a   Hata, Katsura ^a   Tsuruoka, Akihiko ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 3 [4 (4 CYANOPHENYL)THIAZOL 2 YL] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL) 2 BUTANOL; ANTIFUNGAL AGENT; E 1010; RAVUCONAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ASPERGILLOSIS; CANDIDIASIS; DOG; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNE DEFICIENCY; LUNG INFECTION; MOUSE; MYCOSIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SHORT SURVEY;

EID: 0029881612     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1996.021.01.333681     Document Type: Article

References (10)

1. Naito, T , Hata, K., Kaku, Y., Tsuruoka, A., Tsukada, I., Yanagisawa, M., Toyosawa, T., Nara, K. (Eisai Co., Ltd.). Azole antifungal agents, process for the preparation thereof and intermediates. EP 667346, JP 95223950.
2. a) Konos, T., Miyaoka, T., Tajima, Y., Oida, S. Triazole antifungals. III. Stereocontrolled synthesis of an optically active triazolylmethyloxirane precursor to antifungal oxazolodine derivatives. Chem Pharm Bull 1991, 39: 2241-6.
3. b) Tasaka, A., Tamura, N., Matsushita, Y., Teranishi, K., Hayashi, R., Okonogi, K., Itoh, K. Optically active antifungal azoles. I. Synthesis and antifungal activity of (2R,3R) - 2 - (2,4 - difluorophenyl) - 3 - mercapto - 1 - (1H - 1,2,4-triazol-1-yl) -2-butanol and stereoisomers. Chem Pharm Bull 1993, 41: 1035-42.
4. c) Saji, I., Tamoto, K., Tanaka, Y., Fujimoto, K., Ohashi, N., Stereoselective synthesis of antifungal agent threo-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1H-1,2,4-triazol-1-yl) -2-butanol (SM-8668). Bull Chem Soc Jpn 1994, 67: 1427-33.
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6. Hata, K., Ueno, J., Miki, H., Toyosawa, T., Katsu, K., Nakamura, T., Horie, T. ER-30346, a novel antifungal triazole: III. In vitro activity and its mode of action. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F92.
7. Yamada, H., Tsuda, T., Watanabe, T., Ohhashi, M., Murakami, K., Mochizuki, H. In vitro and in vivo antifungal activities of D0870, a new triazole agent. Antimicrob Agents Chemother 1993, 37: 2412-7.
8. Toyosawa, T., Hata, K., Ueno, J., Miki, H., Moriyama, M., Katsu, K. ER-30346, a novel antifungal triazole: II. In vivo activity against experimental infections. 35th Intersci Conf Antimicrob Agents Chemother (Sept 17-20, San Francisco) 1995, Abst F93.
9. Yamada, H., Hamamoto, H., Mochizuki, H. Effect of MJR-1762, a new gel formulation of miconazole on experimental oral candidosis in rats. Jpn J Med Mycol 1992, 33: 329-37.
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