Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

Molecular Psychiatry

Volumn 18, Issue 5, 2013, Pages 568-575

  Velez J I ^a   Chandrasekharappa, S C ^a   Henao, E ^b   Martinez, A F ^a   Harper, U ^a   Jones, M ^a   Solomon, B D ^a   Lopez, L ^b   Garcia, G ^b   Aguirre Acevedo, D C ^b   Acosta Baena, N ^b   Correa, J C ^c   Lopera Gomez C M ^c   Jaramillo Elorza, M C ^c   Rivera, D ^b   Kosik, K S ^d   Schork, N J ^e   Swanson, J M ^f,g   Lopera, F ^b   Arcos Burgos, M ^a,b,h  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^c UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h Australian National University   (Australia)

Author keywords

Alzheimer's disease; bootstrap; DNA pooling; GWAS; modifiers; PSEN1

Indexed keywords

PROTEIN; PSEN1 PROTEIN; UNCLASSIFIED DRUG; ALANINE; GLUTAMIC ACID; PRESENILIN 1;

AGE; ALZHEIMER DISEASE; ARTICLE; BOOTSTRAPPING; COHORT ANALYSIS; DISEASE SEVERITY; DNA EXTRACTION; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; FACTUAL DATABASE; FEMALE; FOUNDER EFFECT; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MALE; MUTATION; ONSET AGE; QUANTITATIVE TRAIT LOCUS; STATISTICS AND NUMERICAL DATA;

AGE OF ONSET; ALANINE; ALZHEIMER DISEASE; COHORT STUDIES; DATABASES, FACTUAL; FEMALE; FOUNDER EFFECT; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLUTAMIC ACID; HUMANS; MALE; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PRESENILIN-1; QUANTITATIVE TRAIT LOCI;

EID: 84876682447     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2012.81     Document Type: Article

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