Metabolism of a potent neuroprotective hydrazide

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 10, 2013, Pages 2733-2741

  Chiruta, Chandramouli ^a   Zhao, Yanrong ^b   Tang, Fangling ^b   Wang, Tao ^b   Schubert, David ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b Pharmaron Beijing Co Ltd   (China)

Author keywords

Alzheimer's; Hydrazines; Metabolites; Microsomes; Neuroprotective

Indexed keywords

2,2,2 TRIFLUORO N (4 (HYDROXYMETHYL) 2 METHYLPHENYL) N' (3 METHOXYBENZYLIDENE)ACETOHYDRAZIDE; AROMATIC AMINE; DRUG METABOLITE; HYDRAZIDE DERIVATIVE; HYDRAZINE; N (2,4 DIMETHYLPHENYL) 2,2,2 TRIFLUORO N' (3 HYDROXYBENZYLI DENE)ACETOHYDRAZIDE; N (2,4 DIMETHYLPHENYL) 2,2,2 TRIFLUORO N' (3 METHOXYBENZYLI DENE)ACETOHYDRAZIDE; N' (3,4 DIHYDROXYBENZYLIDENE) N (2,4 DIMETHYLPHENYL) 2,2,2 TRIFLUOROACETOHYDRAZIDE; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CARCINOGENICITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; DRUG STABILITY; EMBRYO; HUMAN; HUMAN CELL; MICROSOME; MOUSE; NEUROPROTECTION; NONHUMAN; PLASMA; RAT;

ALZHEIMER DISEASE; ANIMALS; DRUG DISCOVERY; HUMANS; HYDRAZINES; MALE; MICE; MICE, INBRED BALB C;

ANIMALIA; RODENTIA;

EID: 84876678963     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.020     Document Type: Article

References (18)

1. Q. Chen, M. Prior, R. Dargusch, A. Roberts, R. Riek, C. Eichmann, C. Chiruta, T. Akaishi, K. Abe, P. Maher, and D. Schubert PLoS One 6 2011 e27865
2. S.G. Kucukguzel, I. Kucukguzel, and M. Ulgen Farmaco 55 2000 624
3. H.G. Neumann Crit. Rev. Toxicol. 37 2007 211
4. R. Benigni, and L. Passerini Mutat Res. 511 2002 191
5. L. Malca-Mor, and A.A. Stark Appl. Environ. Microbiol. 44 1982 801
6. S. Rollas, and S.G. Kucukguzel Molecules 2007 1910 12
7. C. Behl, J.B. Davis, R. Lesley, and D. Schubert Cell 77 1994 817
8. I. Maezawa, H.S. Hong, H.C. Wu, S.K. Battina, S. Rana, T. Iwamoto, G.A. Radke, E. Pettersson, G.M. Martin, D.H. Hua, and L.W. Jin J. Neurochem. 98 2006 57
9. Y. Liu, R. Dargusch, P. Maher, and D. Schubert J. Neurochem. 105 2008 1336
10. M. Ulgen, U. Ozer, I. Kucukguzel, and J.W. Gorrod Drug Metab. Drug Interact. 14 1997 83
11. M. Ulgen, B.B. Durgun, S. Rollas, and J.W. Gorrod Drug Metab. Drug Interact. 13 1997 285
12. L. Tapia-Arancibia, E. Aliaga, M. Silhol, and S. Arancibia Brain Res. Rev. 59 2008 201
13. K. Abe, M. Takayanagi, and H. Saito Jpn. J. Pharmacol. 53 1990 221
14. D.L. McPhie, R.K. Lee, C.B. Eckman, D.H. Olstein, S.P. Durham, D. Yager, S.G. Younkin, R.J. Wurtman, and R.L. Neve J. Biol. Chem. 272 1997 24743
15. F.M. LaFerla, K.N. Green, and S. Oddo Nat. Rev. Neurosci. 8 2007 499
16. B.L. Sopher, K. Fukuchi, A.C. Smith, K.A. Leppig, C.E. Furlong, and G.M. Martin Brain Res. Mol. Brain Res. 26 1994 207
17. J.B. Davis, and P. Maher Brain Res. 652 1994 169
18. S. Tan, D. Schubert, and P. Maher Curr. Top. Med. Chem. 1 2001 497