Endoscopic imaging to assess alveolar mechanics during quasi-static and dynamic ventilatory conditions in rats with noninjured and injured lungs

Critical Care Medicine

Volumn 41, Issue 5, 2013, Pages 1286-1295

  Schwenninger, David ^a   Runck, Hanna ^a   Schumann, Stefan ^a   Haberstroh, Jörg ^a   Priebe, Hans Joachim ^a   Guttmann, Josef ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

alveolar dynamics; alveolar mechanics; endoscopy; intravital microscopy; lung; subpleural alveoli

Indexed keywords

AIRWAY PRESSURE; ALVEOLAR MECHANICS; ANIMAL EXPERIMENT; ARTICLE; ENDOSCOPY; LUNG ALVEOLUS; LUNG INJURY; LUNG MECHANICS; MALE; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT;

ACUTE LUNG INJURY; ANIMALS; BRONCHOSCOPY; DISEASE MODELS, ANIMAL; LUNG COMPLIANCE; MALE; POSITIVE-PRESSURE RESPIRATION; PULMONARY ALVEOLI; PULMONARY GAS EXCHANGE; RANDOM ALLOCATION; RATS; RATS, WISTAR; REFERENCE VALUES; RESPIRATORY MECHANICS; VIDEO RECORDING;

EID: 84876677728     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31827712fa     Document Type: Article

References (47)

1. Caramez M P, Kacmarek RM, Helmy M, et al: A comparison of methods to identify open-lung PEEP. Intensive Care Med 2009; 35:740-747
2. Lichtwarck-Aschoff M, Kessler V, Sjöstrand UH, et al: Static versus dynamic respiratory mechanics for setting the ventilator. Br J Anaesth 2000; 85: 577-586
3. Mols G, Brandes I, Kessler V, et al: Volume-dependent compliance in ARDS: proposal of a new diagnostic concept. Intensive Care Med 1999; 25:1084-1091
4. Stahl CA, Möller K, Schumann S, et al: Dynamic versus static respiratory mechanics in acute lung injury and acute respiratory distress syndrome. Crit Care Med 2006; 34:2090-2098
5. Dassow C, Wiechert L, Martin C, et al: Biaxial distension of precision-cut lung slices. J Appl Physiol 2010; 108:713-721
6. Meissner S, Knels L, Koch T, et al.: Ethanol-flling of isolated rabbit lungs to improve 3D imaging of alveolar structures by optical coherence tomography (OCT). Crit Care Med 2009; 179:A4666
7. Mercer RR, Laco JM, Crapo JD: Three-dimensional reconstruction of alveoli in the rat lung for pressure-volume relationships. J Appl Physiol 1987; 62:1480-1487
8. Bickenbach J, Dembinski R, Czaplik M, et al: Comparison of two in vivo microscopy techniques to visualize alveolar mechanics. J Clin Monit Comput 2009; 23:323-332
9. Daly BD, Norman JC: Alveolar morphometrics. 3. Preliminary results with in vivo videomicroscopy. Chest 1974; 65:67-68
10. Nieman G F, Bredenberg CE, Clark WR, et al: Alveolar function following surfactant deactivation. J Appl Physiol 1981; 51:895-904
11. Tabuchi A, Mertens M, Kuppe H, et al: Intravital microscopy of the murine pulmonary microcirculation. J Appl Physiol 2008; 104:338-346
12. Allen GB, Pavone LA, DiRocco JD, et al: Pulmonary impedance and alveolar instability during injurious ventilation in rats. J Appl Physiol 2005; 99: 723-730
13. DiRocco JD, Pavone LA, Carney DE, et al: Dynamic alveolar mechanics in four models of lung injury. Intensive Care Med 2006; 32:140-148
14. Gatto LA, Fluck RR Jr: Alveolar mechanics in the acutely injured lung: role of alveolar instability in the pathogenesis of ventilator-induced lung injury. Respir Care 2004; 49:1045-1055
15. Mertens M, Tabuchi A, Meissner S, et al: Alveolar dynamics in acute lung injury: heterogeneous distension rather than cyclic opening and collapse. Crit Care Med 2009; 37:2604-2611
16. Schiller HJ, McCann UG 2nd, Carney DE, et al: Altered alveolar mechanics in the acutely injured lung. Crit Care Med 2001; 29:1049-1055
17. Carney D, DiRocco J, Nieman G: Dynamic alveolar mechanics and ventilator-induced lung injury. Crit Care Med 2005; 33(3 Suppl):S122-S128
18. Pavone L, Albert S, DiRocco J, et al: Alveolar instability caused by mechanical ventilation initially damages the nondependent normal lung. Crit Care 2007; 11:R104
19. Pavone LA, Albert S, Carney D, et al: Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics. Crit Care 2007; 11:R64
20. Daly BD, Hughes DA, Norman JC: Alveolar morphometrics: effects of positive end-expiratory pressure. Surgery 1974; 76:624-629
21. Halter JM, Steinberg JM, Gatto LA, et al: Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability. Crit Care 2007; 11:R20
22. Halter JM, Steinberg JM, Schiller HJ, et al: Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Respir Crit Care Med 2003; 167:1620-1626
23. McCann UG 2nd, Schiller HJ, Carney DE, et al: Visual validation of the mechanical stabilizing effects of positive end-expiratory pressure at the alveolar level J Surg Res 2001; 99: 335-342
24. Steinberg J, Schiller HJ, Halter JM, et al: Tidal volume increases do not affect alveolar mechanics in normal lung but cause alveolar overdisten-sion and exacerbate alveolar instability after surfactant deactivation. Crit Care Med 2002; 30:2675-2683
25. DiRocco JD, Carney DE, Nieman GF: Correlation between alveolar recruitment/derecruitment and infection points on the pressure-volume curve. Intensive Care Med 2007; 33:1204-1211
26. Schiller HJ, Steinberg J, Halter J, et al: Alveolar infation during generation of a quasi-static pressure/volume curve in the acutely injured lung. Crit Care Med 2003; 31:1126-1133
27. Otis AB, McKerrow CB, Bartlett RA, et al: Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol 1956; 8:427-443
28. Schumann S, Burcza B, Haberthuer C, et al.: Estimating the intratidal compliance profle with the new gliding-SLICE method. Crit Care 2010; 14:P176
29. Schwenninger D, Runck H, Schumann S, et al: Intravital microscopy of subpleural alveoli via transthoracic endoscopy. J Biomed Opt 2011; 16:046002
30. Schwenninger D, Schumann S, Guttmann J: In vivo characterization of mechanical tissue properties of internal organs using endoscopic microscopy and inverse fnite element analysis. J Biomech 2011; 44:487-493
31. Schwenninger D, Runck H, Schumann S, et al: Locally measured shear moduli of pulmonary tissue and global lung mechanics in mechanically ventilated rats. J Appl Physiol 2012; 113:273-280
32. Schuessler TF, Bates JH: A computer-controlled research ventilator for small animals: design and evaluation. I E EE Trans Biomed Eng 1995; 42: 860-866
33. Luecke T, Meinhardt J P, Herrmann P, et al: Oleic acid vs saline solution lung lavage-induced acute lung injury: effects on lung morphology, pressure-volume relationships, and response to positive end-expiratory pressure. Chest 2006; 130:392-401
34. Guttmann J, Eberhard L, Fabry B, et al: Time constant/volume relationship of passive expiration in mechanically ventilated ARDS patients. Eur Respir J 1995; 8:114-120
35. Armbruster C, Schneider M, Schumann S, et al: Characteristics of highly fexible PDMS membranes for long-term mechanostimulation of biological tissue. J Biomed Mater Res Part B Appl Biomater 2009; 91:700-705
36. Xu C, Prince JL: Snakes, shapes, and gradient vector fow. IEEE Trans Image Process 1998; 7:359-369
37. Schwenninger D, Möller K, Liu H, et al: Automated analysis of intratidal dynamics of alveolar geometry from microscopic endoscopy. IEEE Trans Biomed Eng 2010; 57:415-421
38. Marr D, Hildreth E: Theory of edge detection. Proc R Soc Lond, B, Biol Sci 1980; 207:187-217
39. Daly BD, Parks GE, Edmonds CH, et al: Dynamic alveolar mechanics as studied by videomicroscopy. Respir Physiol 1975; 24:217-232
40. Mercer RR, Crapo JD: Three-dimensional reconstruction of the rat acinus. J Appl Physiol 1987; 63:785-794
41. Ganzert S, Möller K, Steinmann D, et al: Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs: an investigation based on a viscoelastic model. Crit Care 2009; 13:R199
42. Hermle G, Mols G, Zügel A, et al: Intratidal compliance-volume curve as an alternative basis to adjust positive end-expiratory pressure: a study in isolated perfused rabbit lungs. Crit Care Med 2002; 30:1589-1597
43. Mols G, Hermle G, Fries G, et al: Different strategies to keep the lung open: a study in isolated perfused rabbit lungs. Crit Care Med 2002; 30:1598-1604
44. Kirchner EA, Mols G, Hermle G, et al: Reduced activation of immuno-modulatory transcription factors during positive end-expiratory pressure adjustment based on volume-dependent compliance in isolated perfused rabbit lungs. Br J Anaesth 2005; 94:530-535
45. Schumann S, Vimlati L, Kawati R, et al: Analysis of dynamic intra-tidal compliance in a lung collapse model. Anesthesiology 2011; 114:1111-1117
46. Guttmann J, Eberhard L, Fabry B, et al.: Determination of volume-dependent respiratory system mechanics in mechanically ventilated patients using the new SLICE method. Technol Health Care 1994; 2:175-191
47. Zhao Z, Steinmann D, Frerichs I, et al: PEEP titration guided by ventilation homogeneity: a feasibility study using electrical impedance tomography. Crit Care 2010; 14:R8