Tidal volume increases do not affect alveolar mechanics in normal lung but cause alveolar overdistension and exacerbate alveolar instability after surfactant deactivation

Critical Care Medicine

Volumn 30, Issue 12, 2002, Pages 2675-2683

  Steinberg, Jay ^a   Schiller, Henry J ^a   Halter, Jeffrey M ^a   Gatto, Louis A ^b   Dasilva, Monica ^a   Amato, Marcelo ^c   McCann, Ulysse G ^a   Nieman, Gary F ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Alveoli; Mechanical ventilation; Surfactant deactivation; Tidal volume

Indexed keywords

LUNG SURFACTANT; POLYSORBATE 20; POLYSORBATE; SURFACTANT;

ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; IMAGE ANALYSIS; IN VIVO STUDY; INSPIRATORY CAPACITY; LAVAGE; LUNG ALVEOLUS; LUNG ALVEOLUS SURFACE TENSION; MICROSCOPY; NONHUMAN; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; SWINE; TIDAL VOLUME; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; BREATHING MECHANICS; EVALUATION; LUNG LAVAGE; METHODOLOGY; PHYSIOLOGY;

ANIMALS; BRONCHOALVEOLAR LAVAGE; MICROSCOPY, VIDEO; POLYSORBATES; PULMONARY ALVEOLI; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY MECHANICS; SURFACE-ACTIVE AGENTS; SWINE; TIDAL VOLUME;

EID: 0036884055     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200212000-00011     Document Type: Article

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