Systematic biases in DNA copy number originate from isolation procedures

Genome Biology

Volumn 14, Issue 4, 2013, Pages

  van Heesch, Sebastiaan ^a   Mokry, Michal ^a,b   Boskova, Veronika ^a   Junker, Wade ^c   Mehon, Rajdeep ^d   Toonen, Pim ^a   de Bruijn, Ewart ^a   Shull, James D ^c,e   Aitman, Timothy J ^d   Cuppen, Edwin ^a   Guryev, Victor ^a,f  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Copy number variation; DNA isolation; Technological bias; Tissue specificity

Indexed keywords

CHROMATIN ASSEMBLY AND DISASSEMBLY; COPY NUMBER VARIATION; DNA BASE COMPOSITION; DNA ISOLATION; DNA REPLICATION TIMING; GENE AMPLIFICATION; GENE EXPRESSION; GERM LINE; INFORMATION RETRIEVAL; ISOCHORE; ISOLATION PROCEDURE; NEXT GENERATION SEQUENCING; STATISTICAL BIAS; ANIMAL; ARTIFACT; DNA SEQUENCE; FRACTIONATION; GENETICS; ISOLATION AND PURIFICATION; PROCEDURES; RAT; SENSITIVITY AND SPECIFICITY; STANDARDS;

DNA;

ANIMALS; ARTIFACTS; CHEMICAL FRACTIONATION; DNA; DNA COPY NUMBER VARIATIONS; RATS; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA;

EID: 84876670514     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2013-14-4-r33     Document Type: Article

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