Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4

Journal of Organic Chemistry

Volumn 78, Issue 8, 2013, Pages 3616-3635

  Reeves, Jonathan T ^a   Fandrick, Daniel R ^a   Tan, Zhulin ^a   Song, Jinhua J ^a   Rodriguez, Sonia ^a   Qu, Bo ^a   Kim, Soojin ^a   Niemeier, Oliver ^b   Li, Zhibin ^a   Byrne, Denis ^a   Campbell, Scot ^a   Chitroda, Ashish ^a   Decroos, Phil ^a   Fachinger, Thomas ^b   Fuchs, Victor ^a   Gonnella, Nina C ^a   Grinberg, Nelu ^a   Haddad, Nizar ^a   Jäger, Burkhard ^b   Lee, Heewon ^a   Lorenz, Jon C ^a   Ma, Shengli ^a   Narayanan, Bikshandarkoil A ^a   Nummy, Larry J ^a   Premasiri, Ajith ^a   Roschangar, Frank ^a   Sarvestani, Max ^a   Shen, Sherry ^a   Spinelli, Earl ^a   Sun, Xiufeng ^a   Varsolona, Richard J ^a   Yee, Nathan ^a   Brenner, Michael ^b   Senanayake, Chris H ^a   more..

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC SYNTHESIS; CROSS-COUPLINGS; DIASTEREO-SELECTIVITY; DIASTEREOMERIC; LARGE SCALE SYNTHESIS; PROPARGYLATION; TRAPPING REACTION; TRIFLUOROMETHYLKETONE;

KETONES; REACTION INTERMEDIATES;

HORMONES;

ANISOLE; BI 653048; GLUCOCORTICOID; UNCLASSIFIED DRUG;

ARTICLE; CROSS COUPLING REACTION; CRYSTALLIZATION; DRUG SYNTHESIS; PARTICLE SIZE; STEREOCHEMISTRY;

AMIDES; BENZAMIDES; GLUCOCORTICOIDS; MOLECULAR STRUCTURE; PYRIDINES; PYRROLES; STEREOISOMERISM;

EID: 84876592433     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo400079z     Document Type: Article

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