Self-catalytic DNA depurination underlies human β-globin gene mutations at codon 6 that cause anemias and thalassemias

Journal of Biological Chemistry

Volumn 288, Issue 16, 2013, Pages 11581-11589

  Alvarez Dominguez, Juan R ^a,b   Amosova, Olga ^a   Fresco, Jacques R ^a  

^a PRINCETON UNIVERSITY   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEPURINATION; GLOBIN GENE; HAPLOTYPES; IN-VITRO; IN-VIVO; MUTAGENICITY; SELF-CATALYTIC; SOMATIC MUTATION;

HEMOGLOBIN;

GENES;

HEMOGLOBIN BETA CHAIN;

ANEMIA; APURINIC SITE; ARTICLE; BETA GLOBIN GENE; CATALYSIS; CODON; DNA DEPURINATION; DNA METABOLISM; DNA SEQUENCE; DNA STRUCTURE; GENE MUTATION; GENETIC CONSERVATION; GENETIC VARIABILITY; HAPLOTYPE; MOLECULAR EVOLUTION; PRIORITY JOURNAL; THALASSEMIA;

ANEMIA; ANIMALS; BETA-GLOBINS; CODON; DNA; HUMANS; MUTATION; NUCLEIC ACID CONFORMATION; THALASSEMIA;

EID: 84876583451     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.454744     Document Type: Article

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