ValidNESs: A database of validated leucine-rich nuclear export signals

Nucleic Acids Research

Volumn 41, Issue D1, 2013, Pages

  Fu, Szu Chin ^a   Huang, Hsuan Cheng ^b   Horton, Paul ^c   Juan, Hsueh Fen ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE;

ACCESS TO INFORMATION; ARTICLE; COMPUTER INTERFACE; DATA BASE; DATA EXTRACTION; INFORMATION STORAGE; NUCLEAR EXPORT SIGNAL; ONLINE SYSTEM; PREDICTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; VALIDNESS DATABASE;

ANIMALS; DATABASES, PROTEIN; HUMANS; INTERNET; LEUCINE; NUCLEAR EXPORT SIGNALS; PROTEINS;

EID: 84876581131     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks936     Document Type: Article

References (25)

1. Bogerd, H.P., Fridell, R.A., Benson, R.E., Hua, J. and Cullen, B.R. (1996) Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol. Cell. Biol., 16, 4207-4214.
2. Kosugi, S., Hasebe, M., Tomita, M. and Yanagawa, H. (2008) Nuclear export signal consensus sequences defined using a localization-based yeast selection system. Traffic, 9, 2053-2062.
3. Fu, S.-C., Imai, K. and Horton, P. (2011) Prediction of leucine-rich nuclear export signal containing proteins with NESsential. Nucleic Acids Res., 39, e111.
4. Turner, J.G. and Sullivan, D.M. (2008) CRM1-mediated nuclear export of proteins and drug resistance in cancer. Curr. Med. Chem., 15, 2648-2655.
5. van der Watt, P.J., Maske, C.P., Hendricks, D.T., Parker, M.I., Denny, L., Govender, D., Birrer, M.J. and Leaner, V.D. (2009) The Karyopherin proteins, Crm1 and Karyopherin b1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int. J. Cancer, 124, 1829-1840.
6. Hope, T.J. (1999) The ins and outs of HIV Rev. Arch. Biochem. Biophys., 365, 186-191.
7. Iwatsuki-Horimoto, K., Horimoto, T., Fujii, Y. and Kawaoka, Y. (2004) Generation of influenza A Virus NS2 (NEP) mutants with an altered nuclear export signal sequence. J. Virol., 78, 10149-10155.
8. Schmid, M., Gonzalez, R.A. and Dobner, T. (2012) CRM1-dependent transport supports cytoplasmic accumulation of adenoviral early transcripts. J. Virol., 86, 2282-2292.
9. la Cour, T., Gupta, R., Rapacki, K., Skriver, K., Poulsen, F.M. and Brunak, S. (2003) NESbase version 1.0: a database of nuclear export signals. Nucleic Acids Res., 31, 393-396.
10. la Cour, T., Kiemer, L., Mølgaard, A., Gupta, R., Skriver, K. and Brunak, S. (2004) Analysis and prediction of leucine-rich nuclear export signals. Protein Eng. Des. Sel., 17, 527-536.
11. Nilsen, T., Rosendal, K.R., Sørensen, V., Wesche, J., Olsnes, S. and Wiedlocha, A. (2007) A nuclear export sequence located on a beta-strand in fibroblast growth factor-1. J. Biol. Chem., 282, 26245-26256.
12. Kutay, U. and Güttinger, S. (2005) Leucine-rich nuclear-export signals: born to be weak. Trends Cell Biol., 15, 121-124.
13. Wen, W., Meinkoth, J.L., Tsien, R.Y. and Taylor, S.S. (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell, 82, 463-473.
14. Kudo, N., Taoka, H., Toda, T., Yoshida, M. and Horinouchi, S. (1999) A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1. J. Biol. Chem., 274, 15151-15158.
15. Henderson, B.R. and Eleftheriou, A. (2000) A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals. Exp. Cell Res., 256, 213-224.
16. Fornerod, M., Ohno, M., Yoshida, M. and Mattaj, I.W. (1997) CRM1 is an export receptor for leucine-rich nuclear export signals. Cell, 90, 1051-1060.
17. Neuber, A., Franke, J., Wittstruck, A., Schlenstedt, G., Sommer, T. and Stade, K. (2008) Nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast. Mol. Cell. Biol., 28, 5348-5358.
18. O'Neill, R.E., Talon, J. and Palese, P. (1998) The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO J., 17, 288-296.
19. Thompson, M.E. (2005) An amino-terminal motif functions as a second nuclear export sequence in BRCA1. J. Biol. Chem., 280, 21854-21857.
20. Salwinski, L., Miller, C.S., Smith, A.J., Pettit, F.K., Bowie, J.U. and Eisenberg, D. (2004) The database of interacting proteins: 2004 update. Nucleic Acids Res., 32, D449-D451.
21. Kerrien, S., Aranda, B., Breuza, L., Bridge, A., Broackes-Carter, F., Chen, C., Duesbury, M., Dumousseau, M., Feuermann, M., Hinz, U. et al. (2012) The IntAct molecular interaction database in 2012. Nucleic Acids Res., 40, D841-D846.
22. Licata, L., Briganti, L., Peluso, D., Perfetto, L., Iannuccelli, M., Galeota, E., Sacco, F., Palma, A., Nardozza, A.P., Santonico, E. et al. (2012) MINT, the molecular interaction database: 2012 update. Nucleic Acids Res., 40, D857-D861.
23. Szklarczyk, D., Franceschini, A., Kuhn, M., Simonovic, M., Roth, A., Minguez, P., Doerks, T., Stark, M., Muller, J., Bork, P. et al. (2011) The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res., 39, D561-D568.
24. Nair, R., Carter, P. and Rost, B. (2003) NLSdb: database of nuclear localization signals. Nucleic Acids Res., 31, 397-399.
25. Engelsma, D., Rodriguez, J.A., Fish, A., Giaccone, G. and Fornerod, M. (2007) Homodimerization antagonizes nuclear export of survivin. Traffic, 8, 1495-1502.