Glucose control of glucagon secretion: There is more to it than K ATP channels

Diabetes

Volumn 62, Issue 5, 2013, Pages 1391-1393

  Gylfe, Erik ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM ION; GLUCAGON; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TOLBUTAMIDE; ZINC ION;

DEPOLARIZATION; DIABETES MELLITUS; DOWNSTREAM PROCESSING; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; INSULIN RELEASE; NONHUMAN; NOTE; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; GLUCAGON; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; KATP CHANNELS; SOMATOSTATIN-SECRETING CELLS; TOLBUTAMIDE;

EID: 84876569656     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0193     Document Type: Note

References (20)

1. Unger RH, Cherrington AD. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J Clin Invest 2012;122:4-12
2. + channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 2001;4:507-512
3. Thorens B. Brain glucose sensing and neural regulation of insulin and glucagon secretion. Diabetes Obes Metab 2011;13(Suppl. 1):82-88
4. Östenson CG. Regulation of glucagon release: effects of insulin on the pancreatic A2-cell of the guinea pig. Diabetologia 1979;17:325-330 (Pubitemid 10204575)
5. Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB. Islet β-cell secretion determines glucagon release from neighbouring α-cells. Nat Cell Biol 2003;5:330-335 (Pubitemid 36432297)
6. Rorsman P, Berggren PO, Bokvist K, et al. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature 1989;341:233-236 (Pubitemid 19231723)
7. Starke A, Imamura T, Unger RH. Relationship of glucagon suppression by insulin and somatostatin to the ambient glucose concentration. J Clin Invest 1987;79:20-24 (Pubitemid 17232493)
8. Bode HP, Weber S, Fehmann HC, Göke B. A nutrient-regulated cytosolic calcium oscillator in endocrine pancreatic glucagon-secreting cells. Pflugers Arch 1999;437:324-334 (Pubitemid 29071930)
9. Liu YJ, Vieira E, Gylfe E. A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic α-cell. Cell Calcium 2004;35:357-365 (Pubitemid 38351204)
10. Vieira E, Salehi A, Gylfe E. Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic α cells. Diabetologia 2007;50:370-379
11. ATP-channels and glucose-regulated glucagon secretion. Trends Endocrinol Metab 2008;19:277-284
12. Leclerc I, Sun G, Morris C, Fernandez-Millan E, Nyirenda M, Rutter GA. AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells. Diabetologia 2011;54:125-134
13. Cheng-Xue R, Gómez-Ruiz A, Antoine N, et al. Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of KATP channels from both α-cells and δ-cells. Diabetes 2013;62:1612-1622
14. Salehi A, Vieira E, Gylfe E. Paradoxical stimulation of glucagon secretion by high glucose concentrations. Diabetes 2006;55:2318-2323 (Pubitemid 44743630)
15. Göpel S, Zhang Q, Eliasson L, et al. Capacitance measurements of exocytosis in mouse pancreatic α-, β- and δ-cells within intact islets of Langerhans. J Physiol 2004;556:711-726 (Pubitemid 38660309)
16. 2+ oscillations in pancreatic islet cells secreting glucagon and somatostatin. Biochem Biophys Res Commun 1995;208:644-649
17. Hellman B, Salehi A, Grapengiesser E, Gylfe E. Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon. Biochem Biophys Res Commun 2012;417:1219-1223
18. Hellman B, Salehi A, Gylfe E, Dansk H, Grapengiesser E. Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets. Endocrinology 2009;150:5334-5340
19. Nadal A, Quesada I, Soria B. Homologous and heterologous asynchronicity between identified α-, β- and δ-cells within intact islets of Langerhans in the mouse. J Physiol 1999;517:85-93 (Pubitemid 29243473)
20. Le Marchand SJ, Piston DW. Glucose suppression of glucagon secretion: metabolic and calcium responses from a-cells in intact mouse pancreatic islets. J Biol Chem 2010;285:14389-14398