Cyclic changes in HIV shedding from the female genital tract during the menstrual cycle

Journal of Infectious Diseases

Volumn 207, Issue 10, 2013, Pages 1616-1620

  Curlin, Marcel E ^a,b   Leelawiwat, Wanna ^b   Dunne, Eileen F ^a   Chonwattana, Wannee ^b   Mock, Philip A ^b   Mueanpai, Famui ^b   Thep Amnuay, Sukhon ^a   Whitehead, Sara J ^a,b   McNicholl, Janet M ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b MINISTRY OF PUBLIC HEALTH   (Thailand)

Author keywords

female; genital tract; HIV; menstrual cycle; mucosal; shedding; Thailand; transmission

Indexed keywords

ACICLOVIR; ORAL CONTRACEPTIVE AGENT; PLACEBO; PROGESTERONE;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; FEMALE GENITAL SYSTEM; FOLLICULAR PHASE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LUTEAL PHASE; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; MIXED INFECTION; NONHUMAN; OVULATION; PERIOVULATORY PHASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VIRUS DETECTION; VIRUS SHEDDING;

ADOLESCENT; ADULT; CD4 LYMPHOCYTE COUNT; COINFECTION; CROSS-OVER STUDIES; FEMALE; GENITALIA, FEMALE; HERPESVIRUS 2, HUMAN; HIV INFECTIONS; HIV-1; HUMANS; LINEAR MODELS; LUTEAL PHASE; MENSTRUAL CYCLE; MIDDLE AGED; RNA, VIRAL; VIRUS SHEDDING; YOUNG ADULT;

EID: 84876568786     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit063     Document Type: Article

References (15)

1. Baeten JM, Kahle E, Lingappa JR, et al. Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission. Science Translational Medicine 2011; 3:77ra29.
2. Villanueva JM, Ellerbrock TV, Lennox JL, et al. The menstrual cycle does not affect human immunodeficiency virus type 1 levels in vaginal secretions. J Infect Dis 2002; 185:170-7. (Pubitemid 34056440)
3. Mostad SB, Jackson S, Overbaugh J, et al. Cervical and vaginal shedding of human immunodeficiency virus type 1-infected cells throughout the menstrual cycle. J Infect Dis 1998; 178:983-91. (Pubitemid 28452189)
4. Goulston C, Stevens E, Gallo D, Mullins JI, Hanson CV, Katzenstein D. Human immunodeficiency virus in plasma and genital secretions during the menstrual cycle. J Infect Dis 1996; 174:858-61. (Pubitemid 26325908)
5. Reichelderfer PS, Coombs RW, Wright DJ, et al. Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. WHS 001 Study Team. AIDS (London, England) 2000; 14:2101-7.
6. Benki S, Mostad SB, Richardson BA, Mandaliya K, Kreiss JK, Overbaugh J. Cyclic shedding of HIV-1 RNA in cervical secretions during the menstrual cycle. J Infect Dis 2004; 189:2192-201. (Pubitemid 38757191)
7. Money DM, Arikan YY, Remple V, et al. Genital tract and plasma human immunodeficiency virus viral load throughout the menstrual cycle in women who are infected with ovulatory human immunodeficiency virus. Am J Obstet Gynecol 2003; 188:122-8. (Pubitemid 36135607)
8. John GC, Sheppard H, Mbori-Ngacha D, et al. Comparison of techniques for HIV-1 RNA detection and quantitation in cervicovaginal secretions. Journal of Acquired Immune Deficiency Syndromes 2001; 26:170-5. (Pubitemid 32224189)
9. Cu-Uvin S, Snyder B, Harwell JI, et al. Association between paired plasma and cervicovaginal lavage fluid HIV-1 RNA levels during 36 months. Journal of Acquired Imune Deficiency Syndromes 2006; 42:584-7. (Pubitemid 44162427)
10. Dunne EF, Whitehead S, Sternberg M, et al. Suppressive acyclovir therapy reduces HIV cervicovaginal shedding in HIV-and HSV-2-infected women, Chiang Rai, Thailand. Journal of Acquired Immune Deficiency Syndromes 2008; 49:77-83.
11. Forhan SE, Dunne EF, Sternberg MR, et al. HIV-1 and HSV-2 genital shedding among coinfected women using self-collected swabs, Chiang Rai, Thailand. Int J STD AIDS 2012; 23:560-564.
12. Lenton EA, Landgren BM, Sexton L. Normal variation in the length of the luteal phase of the menstrual cycle: identification of the short luteal phase. BJOG 1984; 91:685-9. (Pubitemid 14086882)
13. Fox J. Nonparametric Regression: Appendix to An R and S-PLUS Companion to Applied Regression. http://cran.r-project.org/doc/con trib/Fox-Companion/ appendix-nonparametric-regression.pdf. Accessed 30 October 2012.
14. Hale GE, Zhao X, Hughes CL, Burger HG, Robertson DM, Fraser IS. Endocrine features of menstrual cycles in middle and late reproductive age and the menopausal transition classified according to the Staging of Reproductive Aging Workshop (STRAW) staging system. J Clin Endocrinol Metab 2007; 92:3060-7. (Pubitemid 47236371)
15. Greenblatt RM, Ameli N, Grant RM, Bacchetti P, Taylor RN. Impact of the ovulatory cycle on virologic and immunologic markers in HIVinfected women. J Infect Dis 2000; 181:82-90. (Pubitemid 30049036)