HIV-1 and herpes simplex virus type-2 genital shedding among co-infected women using self-collected swabs in Chiang Rai, Thailand

International Journal of STD and AIDS

Volumn 23, Issue 8, 2012, Pages 560-564

  Forhan, S E ^a,b   Dunne, E F ^b   Sternberg, M R ^a   Whitehead, S J ^b,c   Leelawiwat, W ^c   Thepamnuay, S ^c   Chen, C ^b   Evans Strickfaden, T T ^b   McNicholl, J M ^b,c   Markowitz, L E ^b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c MINISTRY OF PUBLIC HEALTH   (Thailand)

Author keywords

Co infection; Genital shedding; Genital viral load; Herpes simplex virus type 2; HIV; HSV; Self collected swabs; Shedding; Thailand; Women

Indexed keywords

ACICLOVIR; PLACEBO; VIRUS DNA;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; FEMALE; GENITAL TRACT INFECTION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; MAJOR CLINICAL STUDY; MIXED INFECTION; PRIORITY JOURNAL; SELF EVALUATION; THAILAND; VAGINA SMEAR; VIRUS LOAD; VIRUS SHEDDING;

ADULT; COINFECTION; FEMALE; GENITALIA, FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HIV INFECTIONS; HIV-1; HUMANS; LONGITUDINAL STUDIES; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; THAILAND; VIRUS SHEDDING; YOUNG ADULT;

EID: 84865827898     PISSN: 09564624     EISSN: None     Source Type: Journal    
DOI: 10.1258/ijsa.2012.011295     Document Type: Article

References (20)

1. Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001;357:1149-53
2. Van de Perre P, Segondy M, Foulongne V, et al. Herpes simplex virus and HIV-1: deciphering viral synergy. Lancet Infect Dis 2008;8:490-7
3. Anderson BL, Cu-Uvin S. Determinants of HIV shedding in the lower genital tract of women. Curr Infect Dis Rep 2008;10:505-11
4. Mbopi-Keou FX, Gresenguet G, Mayaud P, et al. Interactions between herpes simplex virus type 2 and human immunodeficiency virus type 1 infection in African women: opportunities for intervention. J Infect Dis 2000;182:1090-6
5. McClelland RS, Wang CC, Overbaugh J, et al. Association between cervical shedding of herpes simplex virus and HIV-1. AIDS 2002;16:2425-30
6. LeGoff J, Weiss HA, Gresenguet G, et al. Cervicovaginal HIV-1 and herpes simplex virus type 2 shedding during genital ulcer disease episodes. AIDS 2007;21:1569-78
7. Nagot N, Ouedraogo A, Konate I, et al. Roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (HIV-1)-induced immunosuppression on genital and plasma HIV-1 levels. J Infect Dis 2008;198:241-9
8. Tanton C, Weiss HA, Le Goff J, et al. Correlates of HIV-1 genital shedding in Tanzanian women. PLoS One 2011;6:e17480
9. Ouedraogo A, Nagot N, Vergne L, et al. Impact of suppressive herpes therapy on genital HIV-1 RNA among women taking antiretroviral therapy: a randomized controlled trial. AIDS 2006;20:2305-13
10. Nagot N, Ouédraogo A, Foulongne V, et al. Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. N Engl J Med 2007;356:790-9
11. Baeten JM, Strick LB, Lucchetti A, et al. Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial. J Infect Dis 2008;198:1804-8
12. Dunne EF, Whitehead S, Sternberg M, et al. Suppressive acyclovir therapy reduces HIV cervicovaginal shedding in HIV-and HSV-2-infected women, Chiang Rai, Thailand. J Acquir Immune Defic Syndr 2008;49:77-83
13. Delany S, Mlaba N, Clayton T, et al. Impact of aciclovir on genital and plasma HIV-1 RNA in HSV-2/HIV-1 co-infected women: a randomized placebo-controlled trial in South Africa. AIDS 2009;23:461-9
14. Celum C, Wald A, Lingappa JR, et al. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med 2010;362:427-39
15. Helsel DR. More than obvious: better methods for interpreting nondetect data. Environ Sci Technol 2005;39:419A-23A
16. Diggle PJ, Heagerty P, Liang KY, Zeger S. Analysis of Longitudinal Data. New York: Oxford, 2003
17. Hardle W. Smoothing Techniques. New York: Springer-Verlag, 1991
18. Kovacs A, Wasserman SS, Burns D, et al. Determinants of HIV-1 shedding in the genital tract of women. Lancet 2001;358:1593-601
19. Nagot N, Foulongne V, Becquart P, et al. Longitudinal assessment of HIV-1 and HSV-2 shedding in the genital tract of West African women. J Acquir Immune Defic Syndr 2005;39:632-4
20. Wald A, Zeh J, Selke S, Ashley RL, Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med 1995;333:770-5