LMP1-Induced Cell Death May Contribute to the Emergency of Its Oncogenic Property

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Brocqueville, Guillaume ^a   Ndour, Papa Alioune ^a   Ouk, Tan Sothéa ^b   Le Goff, Arnaud ^a   De Witte, Caroline ^a   Mougel, Alexandra ^a   Coll, Jean ^a   Fafeur, Véronique ^a   Le Bourhis, Xuefen ^c   Adriaenssens, Eric ^a  

^a UNIV LILLE   (France)

^b UNIVERSITÉ DE LIMOGES   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GELATINASE B; LATENT MEMBRANE PROTEIN 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; UVOMORULIN; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; MATRIX PROTEIN; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL DEATH; CELL MOTILITY; CELL SUBPOPULATION; CELL SURVIVAL; CELL TRANSFORMATION; CELL TYPE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; CHEMISTRY; CYTOLOGY; DOG; EPSTEIN BARR VIRUS; HEK293 CELL LINE; MDCK CELL LINE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT;

HUMAN HERPESVIRUS 4;

ANIMALS; CELL DEATH; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DOGS; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; HEK293 CELLS; HERPESVIRUS 4, HUMAN; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; ONCOGENE PROTEINS; PROTEIN TRANSPORT; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; VIRAL MATRIX PROTEINS;

EID: 84876565843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060743     Document Type: Article

References (33)

1. Rickinson AB, Kieff K (2007) Epstein-Barr Virus. In: Knipe DM, Howley, P M, editor. Fields Virology. Philadelphia: Lippincott-Raven. pp. 2655-2700.
2. Kaye KM, Izumi KM, Kieff E, (1993) Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc Natl Acad Sci U S A 90: 9150-9154.
3. Groux H, Cottrez F, Montpellier C, Quatannens B, Coll J, et al. (1997) Isolation and characterization of transformed human T-cell lines infected by Epstein-Barr virus. Blood 89: 4521-4530.
4. Masy E, Adriaenssens E, Montpellier C, Crepieux P, Mougel A, et al. (2002) Human monocytic cell lines transformed in vitro by Epstein-Barr virus display a type II latency and LMP-1-dependent proliferation. J Virol 76: 6460-6472.
5. Roberts ML, Cooper NR, (1998) Activation of a ras-MAPK-dependent pathway by Epstein-Barr virus latent membrane protein 1 is essential for cellular transformation. Virology 240: 93-99.
6. Eliopoulos AG, Young LS, (2001) LMP1 structure and signal transduction. Semin Cancer Biol 11: 435-444.
7. Gires O, Zimber-Strobl U, Gonnella R, Ueffing M, Marschall G, et al. (1997) Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. Embo J 16: 6131-6140.
8. Dawson CW, Tramountanis G, Eliopoulos AG, Young LS, (2003) Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J Biol Chem 278: 3694-3704.
9. Eliopoulos AG, Young LS, (1998) Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Oncogene 16: 1731-1742.
10. Eliopoulos AG, Gallagher NJ, Blake SM, Dawson CW, Young LS, (1999) Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production. J Biol Chem 274: 16085-16096.
11. Paine E, Scheinman RI, Baldwin AS Jr, Raab-Traub N, (1995) Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa B/Rel family proteins. J Virol 69: 4572-4576.
12. Dawson CW, Laverick L, Morris MA, Tramoutanis G, Young LS, (2008) Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J Virol 82: 3654-3664.
13. Everly DN Jr, Mainou BA, Raab-Traub N, (2004) Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation. J Virol 78: 13470-13478.
14. Shair KH, Schnegg CI, Raab-Traub N, (2008) EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration. Cancer Res 68: 6997-7005.
15. Hammerschmidt W, Sugden B, Baichwal VR, (1989) The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels. J Virol 63: 2469-2475.
16. Nitta T, Chiba A, Yamashita A, Rowe M, Israel A, et al. (2003) NF-kappaB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus. Cell Signal 15: 423-433.
17. Le Clorennec C, Ouk TS, Youlyouz-Marfak I, Panteix S, Martin CC, et al. (2008) Molecular basis of cytotoxicity of Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) in EBV latency III B cells: LMP1 induces type II ligand-independent autoactivation of CD95/Fas with caspase 8-mediated apoptosis. J Virol 82: 6721-6733.
18. Le Clorennec C, Youlyouz-Marfak I, Adriaenssens E, Coll J, Bornkamm GW, et al. (2006) EBV latency III immortalization program sensitizes B cells to induction of CD95-mediated apoptosis via LMP1: role of NF-kappaB, STAT1, and p53. Blood 107: 2070-2078.
19. Zou P, Kawada J, Pesnicak L, Cohen JI, (2007) Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EBV-transformed B cells. J Virol 81: 10029-10036.
20. Li L, Liu D, Hutt-Fletcher L, Morgan A, Masucci MG, et al. (2002) Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage-colony-stimulating factor and interleukin-4. Blood 99: 3725-3734.
21. Lu JJ, Chen JY, Hsu TY, Yu WC, Su IJ, et al. (1996) Induction of apoptosis in epithelial cells by Epstein-Barr virus latent membrane protein 1. J Gen Virol 77: 1883-1892.
22. Zhang X, Hu L, Fadeel B, Ernberg IT, (2002) Apoptosis modulation of Epstein-Barr virus-encoded latent membrane protein 1 in the epithelial cell line HeLa is stimulus-dependent. Virology 304: 330-341.
23. Zhang X, Sanmun D, Hu L, Fadeel B, Ernberg I, (2007) Epstein-Barr virus-encoded LMP1 promotes cisplatin-induced caspase activation through JNK and NF-kappaB signaling pathways. Biochem Biophys Res Commun 360: 263-268.
24. Kim KR, Yoshizaki T, Miyamori H, Hasegawa K, Horikawa T, et al. (2000) Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Ets1 and invasive growth. Oncogene 19: 1764-1771.
25. Kaykas A, Sugden B, (2000) The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation. Oncogene 19: 1400-1410.
26. Zeng Q, Tan YH, Hong W, (1998) A single plasmid vector (pSTAR) mediating efficient tetracycline-induced gene expression. Anal Biochem 259: 187-194.
27. Ndour PA, Brocqueville G, Ouk TS, Goormachtigh G, Morales O, et al. (2012) Inhibition of latent membrane protein 1 impairs the growth and tumorigenesis of latency II Epstein-Barr virus-transformed T cells. J Virol 86: 3934-3943.
28. Horikawa T, Yang J, Kondo S, Yoshizaki T, Joab I, et al. (2007) Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res 67: 1970-1978.
29. Horikawa T, Yoshizaki T, Kondo S, Furukawa M, Kaizaki Y, et al. (2011) Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma. Br J Cancer 104: 1160-1167.
30. Adriaenssens E, Mougel A, Goormachtigh G, Loing E, Fafeur V, et al. (2004) A novel dominant-negative mutant form of Epstein-Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways. Oncogene 23: 2681-2693.
31. Goormachtigh G, Ouk TS, Mougel A, Tranchand-Bunel D, Masy E, et al. (2006) Autoactivation of the Epstein-Barr virus oncogenic protein LMP1 during type II latency through opposite roles of the NF-kappaB and JNK signaling pathways. J Virol 80: 7382-7393.
32. Bornkamm GW, Berens C, Kuklik-Roos C, Bechet JM, Laux G, et al. (2005) Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res 33: e137.
33. Ndour PA, Ouk TS, Brocqueville G, Mougel A, Vanhecke E, et al. (2010) Inhibition of tumor necrosis factor-induced phenotypes by short intracellular versions of latent membrane protein-1. Cell Signal 22: 303-313.