Asymptomatic plasmodial infection is associated with increased tumor necrosis factor receptor II-expressing regulatory T cells and suppressed type 2 immune responses

Journal of Infectious Diseases

Volumn 207, Issue 10, 2013, Pages 1590-1599

  Wammes, Linda J ^a,b   Wiria, Aprilianto E ^a,b   Toenhake, Christa G ^a   Hamid, Firdaus ^a,c   Liu, Kit Yeng ^a   Suryani, Heni ^b   Kaisar, Maria M M ^a,b   Verweij, Jaco J ^a   Sartono, Erliyani ^a   Supali, Taniawati ^b   Smits, Hermelijn H ^a   Luty, Adrian J ^d,e   Yazdanbakhsh, Maria ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF INDONESIA   (Indonesia)

^c HASANUDDIN UNIVERSITY   (Indonesia)

^d INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

malaria; Th1; Th2; TNFRII; Treg

Indexed keywords

CHLOROQUINE; CYTOKINE; INTERLEUKIN 13; PRIMAQUINE; PYRIMETHAMINE PLUS SULFADOXINE; TRANSCRIPTION FACTOR GATA 3; TUMOR NECROSIS FACTOR RECEPTOR 2;

ADOLESCENT; ARTICLE; ASYMPTOMATIC INFECTION; CELLULAR IMMUNITY; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYTOKINE RELEASE; DISEASE CARRIER; ENDEMIC DISEASE; ERYTHROCYTE; FEMALE; HELPER CELL; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; INDONESIA; LONGITUDINAL STUDY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALARIA; MALARIA FALCIPARUM; MALE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX MALARIA; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SCHOOL CHILD; SINGLE DRUG DOSE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ANTIMALARIALS; ASYMPTOMATIC INFECTIONS; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; ERYTHROCYTES; FEMALE; GATA3 TRANSCRIPTION FACTOR; HUMANS; IMMUNITY, CELLULAR; INDONESIA; INTERLEUKIN-13; LEUKOCYTES, MONONUCLEAR; LONGITUDINAL STUDIES; MALARIA, FALCIPARUM; MALE; PILOT PROJECTS; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PREVALENCE; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS; UP-REGULATION;

EID: 84876562302     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit058     Document Type: Article

References (29)

1. Langhorne J, Ndungu FM, Sponaas AM, Marsh K. Immunity to malaria: more questions than answers. Nature Immunology 2008; 9:725-32. (Pubitemid 351859155)
2. Marsh K, Kinyanjui S. Immune effector mechanisms in malaria. Parasite Immunology 2006; 28:51-60.
3. Males S, Gaye O, Garcia A. Long-term asymptomatic carriage of Plasmodium falciparum protects from malaria attacks: a prospective study among Senegalese children. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2008; 46:516-22. (Pubitemid 351263488)
4. Riley EM, Wahl S, Perkins DJ, Schofield L. Regulating immunity to malaria. Parasite Immunology 2006; 28:35-49.
5. Scholzen A, Minigo G, Plebanski M. Heroes or villains? T regulatory cells in malaria infection. Trends Parasitol 2010; 26:16-25.
6. Walther M, Tongren JE, Andrews L, et al. Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. Immunity 2005; 23:287-96. (Pubitemid 41317796)
7. Bueno LL, Morais CG, Araujo FF, et al. Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites. PloS One 2010; 5:e9623.
8. Goncalves RM, Salmazi KC, Santos BA, et al. CD4+ CD25+ Foxp3+ regulatory T cells, dendritic cells, and circulating cytokines in uncomplicated malaria: do different parasite species elicit similar host responses? Infection and Immunity 2010; 78:4763-72.
9. Jangpatarapongsa K, Chootong P, Sattabongkot J, et al. Plasmodium vivax parasites alter the balance of myeloid and plasmacytoid dendritic cells and the induction of regulatory T cells. European Journal of Immunology 2008; 38:2697-705.
10. Minigo G, Woodberry T, Piera KA, et al. Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria. PLoS Pathogens 2009; 5:e1000402.
11. Walther M, Jeffries D, Finney OC, et al. Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria. PLoS Pathogens 2009; 5: e1000364.
12. Randall LM, Engwerda CR. TNF family members and malaria: old observations, new insights and future directions. Experimental Parasitology 2010; 126:326-31.
13. Scholzen A, Mittag D, Rogerson SJ, Cooke BM, Plebanski M. Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta. PLoS Pathogens 2009; 5:e1000543.
14. Elyazar IR, Hay SI, Baird JK. Malaria distribution, prevalence, drug resistance and control in Indonesia. Advances in Parasitology 2011; 74:41-175.
15. Ende HDA. Health profile of Ende District: Ministry of Health Indonesia 2009. http://www.depkes.go.id/downloads/profil-kesehatan-prov-kab/profil-kes- ende-2009.pdf. Accessed 1 June 2012.
16. Wiria AE, Prasetyani MA, Hamid F, et al. Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study). BMC Infectious Diseases 2010; 10:77.
17. Harijanto PN. Malaria treatment by using artemisinin in Indonesia. Acta medica Indonesiana 2010; 42:51-6.
18. WHO. Nutritional anaemias. Report of a WHO scientific group. 1968.
19. Finney OC, Riley EM, Walther M. Phenotypic analysis of human peripheral blood regulatory T cells (CD4+FOXP3+CD127lo/-) ex vivo and after in vitro restimulation with malaria antigens. European Journal of Immunology 2010; 40:47-60.
20. Hemmer CJ, Holst FG, Kern P, Chiwakata CB, Dietrich M, Reisinger EC. Stronger host response per parasitized erythrocyte in Plasmodium vivax or ovale than in Plasmodium falciparum malaria. Tropical Medicine & International Health : TM & IH 2006; 11:817-23. (Pubitemid 43846441)
21. Robinson LJ, D'Ombrain MC, Stanisic DI, et al. Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea. Infection and Immunity 2009; 77:3033-43.
22. Quelhas D, Puyol L, Quinto L, et al. Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children. BMC Immunology 2012; 13:5.
23. Bereczky S, Montgomery SM, Troye-Blomberg M, Rooth I, Shaw MA, Farnert A. Elevated anti-malarial IgE in asymptomatic individuals is associated with reduced risk for subsequent clinical malaria. International Journal for Parasitology 2004; 34:935-42. (Pubitemid 38813255)
24. Torcia MG, Santarlasci V, Cosmi L, et al. Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria. Proceedings of the National Academy of Sciences of the United States of America 2008; 105:646-51. (Pubitemid 351171762)
25. Farouk SE, Dolo A, Bereczky S, et al. Different antibody-and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in Mali. Microbes and Infection/Institut Pasteur 2005; 7:110-7. (Pubitemid 40431350)
26. van Mierlo GJ, Scherer HU, Hameetman M, et al. Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol 2008; 180: 2747-51.
27. Ito T, Wang YH, Duramad O, et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. The Journal of Experimental Medicine 2005; 202:1213-23. (Pubitemid 41586952)
28. Maizels RM, Yazdanbakhsh M. Immune regulation by helminth parasites: cellular and molecular mechanisms. Nature Reviews Immunology 2003; 3:733-44. (Pubitemid 41070814)
29. Rudra D, Deroos P, Chaudhry A, et al. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nature Immunology 2012; 13:1010-9.