Ileal interposition surgery-induced improvement of hyperglycemia and insulin resistance in Goto-Kakizaki rats by upregulation of TCF7L2 expression

Experimental and Therapeutic Medicine

Volumn 5, Issue 5, 2013, Pages 1511-1515

  Sun, Xu ^a   Song, Maomin ^a   Bai, Rixing ^a   Cheng, Shi ^a   Xing, Ying ^a   Yuan, Huisheng ^a   Wang, Pilin ^a   Zhou, Lisa ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Columbia University in the City of New York ^*  (United States)

Author keywords

Diabetes mellitus; Hyperglycemia; Ileal interposition; T cell factor 7 like 2; Type

Indexed keywords

GLUCOSE; TRANSCRIPTION FACTOR 7 LIKE 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; ILEAL INTERPOSITION SURGERY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH SURGERY; UPREGULATION; WESTERN BLOTTING;

EID: 84876561377     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.998     Document Type: Article

References (23)

1. King H, Aubert RE and Herman WH: Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21: 1414-1431, 1998.
2. Stumvoll M, Goldstein BJ and van Haeften TW: Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365: 1333-1346, 2005.
3. Zimmet P, Alberti KG and Shaw J: Global and societal implications of the diabetes epidemic. Nature 414: 782-787, 2001.
4. Schauer PR, Burguera B, Ikramuddin S, et al: Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg 238: 467-484, 2003.
5. Rubino F, Gagner M, Gentileschi P, et al: The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg 240: 236-242, 2004.
6. Gill RS, Sharma AM, Al-Adra DP, Birch DW and Karmali S: The impact of bariatric surgery in patients with type-2 diabetes mellitus. Curr Diabetes Rev 7: 185-189, 2011.
7. Baggio LL and Drucker DJ: Biology of incretins: GLP-1 and GIP. Gastroenterology 132: 2131-2157, 2007.
8. Chen DC, Stern JS and Atkinson RL: Effects of ileal transposition on food intake, dietary preference, and weight gain in Zucker obese rats. Am J Physiol 258: R269-273, 1990.
9. Rulifson IC, Karnik SK, Heiser PW, et al: Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci USA 104: 6247-6252, 2007.
10. Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH and Maedler K: Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet 18: 2388-2399, 2009.
11. Culnan DM, Albaugh V, Sun M, Lynch CJ, Lang CH and Cooney RN: Ileal interposition improves glucose tolerance and insulin sensitivity in the obese Zucker rat. Am J Physiol Gastrointest Liver Physiol 299: G751-G760, 2010.
12. Strader AD, Vahl TP, Jandacek RJ, Woods SC, D'Alessio DA and Seeley RJ: Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab 288: E447-E453, 2005.
13. Wang TT, Hu SY, Gao HD, et al: Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing GLP-1. Ann Surg 247: 968-975, 2008.
14. Chelikani PK, Shah IH, Taqi E, Sigalet DL and Koopmans HH: Comparison of the effects of Roux-en-Y gastric bypass and ileal transposition surgeries on food intake, body weight, and circulating peptide YY concentrations in rats. Obes Surg 20: 1281-1288, 2010.
15. Patriti A, Aisa MC, Annetti C, et al: How the hindgut can cure type 2 diabetes. Ileal transposition improves glucose metabolism and beta-cell function in Goto-Kakizaki rats through an enhanced Proglucagon gene expression and L-cell number. Surgery 142: 74-85, 2007.
16. Cummings BP, Strader AD, Stanhope KL, et al: Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat. Gastroenterology 138: 2437-2446, 2010.
17. Welters HJ and Kulkarni RN: Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab 19: 349-355, 2008.
18. Angus-Hill ML, Elbert KM, Hidalgo J and Capecchi MR: T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci USA 108: 4914-4919, 2011.
19. Jin T and Liu L: The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol Endocrinol 22: 2383-2392, 2008.
20. Grant SF, Thorleifsson G, Reynisdottir I, et al: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38: 320-323, 2006.
21. Lyssenko V, Lupi R, Marchetti P, et al: Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117: 2155-2163, 2007.
22. Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J and Maedler K: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57: 645-653, 2008.
23. da Silva Xavier G, Mondragon A, Sun G, Chen L, McGinty JA, French PM and Rutter GA: Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. Diabetologia 55: 2667-2676, 2012.