Acupuncture-induced activation of endogenous opioid system

Acupuncture Therapy for Neurological Diseases: A Neurobiological View

Volumn , Issue , 2010, Pages 104-119

  Wen, Guoqiang ^a   Yang, Yilin ^b   Lu, Yang ^c   Xia, Ying ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c Shanghai Research Center for Acupuncture and Meridians   (China)

Author keywords

endorphin; Dynorphin; Enkephalin; Opioid receptors; Release

Indexed keywords

EID: 84876541928     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-10857-0_4     Document Type: Chapter

References (67)

1. + leakage in the cortex. Cell Mol Life Sci 66: 1105-1115
2. Chen XH, Han JS (1992a) All three types of opioid receptors in the spinal cord are important for 2/15 Hz electro-acupuncture analgesia. European Journal of Pharmacology 211: 203-210
3. Chen XH, Han JS (1992b) Analgesia induced by electro-acupuncture of different frequencies is mediated by different types of opioid receptors: another cross-tolerance study. Behavioral Brain Research 47:143-149
4. Chen QS, Zhou DF, Wang YX, Han JS (1981) The relationship between electro-acupuncture analgesia and the content of β-endorphin in rat brain and pituitary gland: Radioimmunoassay. Chinese Science Bulletin 26: 832-833 (in Chinese)
5. Chen QS, Xie CW, Tang J, Han JS (1983) Effects of electric acupuncture on β-endogenous opioid peptide contents of different brain areas in rats. Chinese Science Bulletin 28: 312-315 (in Chinese)
6. Chen BY, Pan XP, Jiang CC, Chen SQ (1984) Correlation of pain threshold and level of p-endorphin-likeimmunoreactive substance in human csf during electro-acupuncture analgesia. Acta Physiologica Sinica 36: 183-187 (in Chinese with English abstract)
7. Chen XH, Geller EB, Adler MW (1996) Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats. The Journal of Pharmacology and Experimental Therapeutics Online 277: 654-660
8. Da CD, Fan B, Zhou JX (1997) Expression of preproenkephalin mrna and its coexistence with fos in rat ar-pag-rvm following tail nociceptive stimulation and acupuncture in quanliao point. Chinese Journal of Neuroscience 4:130-133 + 144
9. Da CD, Fan B, Zhou JX (1998) Preproenkephalin mrna fxpression and co-localized with c-fos in rat brain after acupuncture analgesia. Journal of Shanghai Medical University 25: 19-22
10. Dong YN, Mao MH, Wang XM, Han JS (1998) Changes in the binding characteristics of central κ-opioid receptor during the development of 100Hz electro-acupuncture (EA) tolerance in rats. Acta Physilolgica Sinica 50: 663-670 (in Chinese with English abstract)
11. Fan B, Da CD, Zhou JX (1997) Expression of ppenk and c-fos in rat spinal cord following electrostimulation electroacupuncture analgesia. Journal of Shanghai Medical University 24: 461-464
12. Fei H, Xie GX, Han JS (1987) Low and high frequency electro-acupuncture stimulations release (met5) enkephalin and dynorphin A in rat spinal cord. Chinese Science Bulletin 32: 1496-1501 (in Chinese with English abstract)
13. Fei H, Sun SL, Han JS (1988) New evidence supporting differential release of enkephalin and dynorphin by low and high frequency eletroacupuncture stimulation. Chinese Science Bulletin 33: 703-705 (in Chinese with English abstract)
14. Gao M, He LF (1996) Increase of mu opioid receptor density in rat central nervous system following formalin nociception and its enhancement by electro-acupuncture. Acta Physiologica Sinica 48: 125-131 (in Chinese with English abstract)
15. Guo HF, Wang XM, Tian JH, Hou YP, Han JS (1997) 2 Hz and 100 Hz electro-acupuncture accelerate the expression of genes encoding three opioid peptides in the rat brain. Acta Physiologica Sinica 49: 121-127 (in Chinese with English abstract)
16. Han JS (2003) Acupuncture: Neuropeptide release produced by electrical stimulation of different frequencies. Trends in Neurosciences 26: 17-21
17. Han JS (2004) Acupuncture and endorphins. Neuroscience Letters 36: 258-261
18. Han JS, Wang Q (1992) Mobilization of specific neuropeptides by peripheral stimulation of identified frequencies. News in Physiology Science 7: 176-180 (in Chinese with English abstract)
19. Han JS, Chen XH, Sun SL, Xu XJ, Yuan Y, Yan SC, Hao JX, Terenius L (1991) Effect of low and high frequency TENS on Metenkephalin-Arg-Phe and dynorphin Aimmunoreactivity in human lumbar CSF. Pain 47: 295-298
20. He LF, Dong WQ (1983) Activity of opioid peptidergic system in acupuncture analgesia. Acupuncture and Electro-therapeutics Research 8: 257-266
21. Herz A, Millan M (1989) Participation of opioids and opioid receptors in antinociception at various levels of the nervous system. Farmakologiia-i Toksikologiia 52: 5-12
22. Huang C, Wang Y, Shi YS, Han JS (2000) Study for the opioid mechanisms underlying the analgesia effect induced by high-versus low-frequency electro-acupuncture in mice. Chinese Journal of Pain Medicine 6: 96-103 (in Chinese with English abstract)
23. Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR (1975) Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258: 577-579
24. Ji RR, Zhang Q, Han JS (1993) Electro-acupuncture enhances enkephalin mRNA expression in the spinal cord and medulla, an in situ hybridization study. Acta Physiologica Sinica 45: 395-399 (in Chinese with English abstract)
25. Kim HW, Roh DH, Yoon SY, Kang SY, Kwon YB, Han HJ, Lee HJ, Choi SM, Ryu YH, Beitz AJ, Lee JH (2006) The anti-inflammatory effects of low-and high-frequency electroacupuncture are mediated by peripheral opioids in a mouse air pouch inflammation model. J Altern Complement Med 12: 39-44
26. Li M, Su SG, Chen YW (1997) Inhibitory effect on arrhythmias by morphine microinjection into rabbit hippocampus. Academic Journal of Kunming Medical College18: 37-39 (in Chinese with English abstract)
27. Li P, Tjen-A-Looi S, Longhurst JC (2001) Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electro-acupuncture on reflex autonomic response in cats. Autonomic Neuroscience 89: 38-47
28. Ma CH, Tan LH, Wang CY, Zhao XJ (1995) Effect of acupuncture on the contents of enkephalins in different brain regions of rats with traumatic shock. Acupuncture Research 20: 33-35 (in Chinese with English abstract)
29. Ma MC, Qian H, Ghassemi F, Zhao P, Xia Y (2005) Oxygen sensitive delta-opioid receptor-regulated survival and death signals: Novel insights into neuronal preconditioning and protection. J Biol Chem 280: 16208-16218
30. Pert A, Dionne R, Ng L, Bragin E, Moody TW, Pert CB (1981) Alterations in rat central nervous system endorphins following transauricular electro-acupuncture Brain Res 224: 83-93
31. Sjölund B, Terenius L, Eriksson M (1977) Increased cerebrospinal fluid levels of endorphins after electro-acupuncture. Acta Physiologica Scandinavica 100: 382-384
32. Snyder SH, Matthysse S (1975) Opiate Receptor Mechanisms. Neurosci Res Program Bull 13: 1-166
33. Sodipo JO, Gilly H, Pauser G (1981) Endorphins: mechanism of acupuncture analgesia. The American Journal of Chinese Medicine 9: 249-258
34. Tang J, Han JS (1979) Effects of electro-acupuncture analgesia on opioid-like substance contents in rat brain and pituitary. Chinese Science Bulletin 24: 1095-1096 (in Chinese)
35. Tian XS, Zhou F, Yang R, Xia Y, Wu GC, Guo JC (2008a) Role of 8-opioid receptors in cumulative electro-acupuncture induced protection from ischemic injury in the rat brain. Shanghai Journal of Traditional Chinese Medicine 42: 71-74 (in Chinese with English abstract)
36. Tian XS, Zhou F, Yang R, Xia Y, Wu GC, Guo JC (2008b) Electro-acupuncture protects the brain against ischemic injury via up-regulation of delta-opioid receptors. Journal of Chinese Integrative Medicine 5: 632-638 (in Chinese with English abstract)
37. Wang YJ, Wang SK (1989a) Effects of electro-acupuncture at different hours on leucine-enkephalin contents in rat brain regions. Acupuncture Research 14: 420-423 (in Chinese with English abstract)
38. Wang YJ, Wang SK (1989b) Effects of intraperitoneal injection of naloxone on the analgesic effect and the changes of brain catecholamine contents induced by electro-acupuncture in rats. Acupuncture Research 14: 348-351 (in Chinese with English abstract)
39. Wang Q, Mao L, Han JS (1990) The arcuate nucleus of hypothalamus mediates low but not high frequency electro-acupuncture analgesia in rats, Brain Research 513: 60-65
40. Wang Q, Mao LM, Han JS (1991) The role of parabrachial nucleus in high frequency electro-acupuncture analgesia in rats. Chinese Journal of Physiology Science 7: 363-371 (in Chinese with English abstract)
41. Wang GY, Jiang NC, Yin SS, He ZG (1997a) Effect of electoacupuncture decreasing blood pressure and study on its central mechanisms in rats of acute experimental hypertension. Chinese Acupuncture and Moxibustion 2,105-108 (in Chinese with English abstract)
42. Wang Y, Wang XM, Han JS (1998) Effect of 2 Hz and 100 Hz electro-acupuncture tolerance on the transcription of CNS K opioid receptor mRNA. Journal of Beijing Medical University 30: 1-4 (in Chinese with English abstract)
43. Wu GJ, Chen ZQ (1999) Opioid mu receptors in caudate nucleus contribute to electro-acupuncture and Sm I generating inhibition on nociceptive responses of Pf neurons. Acta Physiologica Sinica 51: 49-54 (in Chinese with English abstract)
44. Wu SX, Zhang ZX, Wang FS, Zou G (1980) Effect of intraventricular cycloheximide on acupuncture analgesia and brain methionineenkephalin. Acta Physiologica Sinica 32: 79-81 (in Chinese with English abstract)
45. Wu SX, Wang FS, Zhang ZX, Zou G (1983) Effect of morphine on methionine-enkephalin content of rabbit brain and cerebrospinal fluid. Chinese Science Bulletin 28: 1274-1275 (in Chinese)
46. Xi GF, Jiang CC, Chen YR, Ding XJ, Li LQ (1995) The Change of Plasma Opioid Peptide Content during Different Phases of Anesthesia Induction. Shanghai Journal of Acupuncture and Moxibustion 14: 53-54 (in Chinese with English abstract)
47. Xia Y, Cao XD, Zhang AZ, Guo XQ, Li P (1985) Inhibitory effect of analogous electro-acupuncture on experimental arrhythmia. Acupuncture & Electro-therapeutics Research 10: 13-34
48. Xia Y, Zhang AZ, Cao XD (1986) Roles of opioid peptides of PAG in analogous electro-acupuncture inhibition of experimental arrhythmia: analyzed by specific antisera microinjection. Acupuncture & Electro-therapeutics Research 11: 191-198
49. Xia Y, Cao XD, Zhang ZA, Tang QM, Xu XR (1989) Relationship between the brain monoamine neurotransmitters and endogenous opioid peptides during inhibition of defense pressor response by inputs of deep paroneal nerve in rabbits. Chinese Science Bulletin 34: 1221-1225
50. Xie CW, Zhang WQ, Hong XJ, Han JS (1984) Relations between the content of central met-enkephalin and leu-enkephalin and the analgesic effect of electro-acupuncture in rats. Acta Physiologica Sinica 36: 192-197 (in Chinese with English abstract)
51. Xie GZ, Zhu DN, Li P (1997) The antihypertensive effect in stress-induced hypertension rats by electrical stimulation at deep peroneal nerve under Zusanli. Shanghai Journal of Acupuncture and Moxibustion 16: 32-33 (in Chinese)
52. Yang YL, Xia XW, Zhang Y, Wang Q, Li L, Luo GH, Xia Y (2009) S-opioid receptor activation attenuates oxidative injury in the ischemic rat brain. BMC Biology 7: 55
53. You XH, Hu P, He CM, Li MP, Wu FH (2005) The influence of injecting naloxone into periaqueductal gray on the curative effect of scalp electoacupuncture in experimental arrhythmic rats. Journal of Clinical Acupuncture and Moxibustion 21: 57-59 (in Chinese with English abstract)
54. Yu YQ, Xia Q (2001) The role of amygdale and central opioid peptide in somatic stimulation induced inhibition of central pressor response. Acupuncture Research 26: 253-259 (in Chinese with English abstract)
55. Yu YH, Gao M, He LF (1994) The time course of acupuncture induced changes in the level of POMC mRNA in hypothalamic arcuate nucleus of the rat. Journal of Shanghai Medical University 21(supplement): 59-61 (in Chinese)
56. Yu YG, Cui CL, Yu JR, Han JS (1999) 100 Hz electro-acupuncture amelioration of tachycardia of morphine withdrawal rats mediated by K-opioid receptor in central nervous system. Journal of Beijing Medical University 31: 1-4 (in Chinese with English abstract)
57. Zhang JH, Haddad GG, Xia Y (2000) δ-, but not μ-and κ-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury. Brain Res 885: 143-153
58. Zhang JH, Qian H, Zhao P, Hong SS, Xia Y (2006) Rapid hypoxia preconditioning protects cortical neurons from glutamate Toxicity Through 8-Opioid Receptor. Stroke 37: 1094-1099
59. Zhao P, Guo JC, Hong SS, Bazzy-Asaad A, Cheng JS, Xia Y (2002) Electro-acupuncture and brain protection from cerebral ischemia: The role of delta-opioid receptor. Program No. 490.13, SfN Abstract. Society for Neuroscience online
60. Zhou L, Jiang JW, Wu GC, Cao XD (1993) Changes of endogenous opioid peptides content in RPGL during acupuncture analgesia. Acta Physiologica Sinica 45: 36-43 (in Chinese with English abstract)
61. Zhou SY, Zhu YP, Gao F, Ye ZG, Xu JF, Xia Q (2003) The regulation of deep peroneal nerve inputs on cardiovascular activity caused by area postrema excitation. Chinese Journal of Applied Physiology 19: 7-9 (in Chinese with English abstract)
62. Zhou F, Guo J, Cheng IS, Wu GC, Xia Y (2007) Electro-acupuncture induced protection from cerebral ischemia is dependent on stimulation intensity and frequency. The proceedings of 3rd World Conference on Stress (Cell Stress Chaperones online 12: 5B-05-P)
63. Zhu MY, Wang XY, Zhang DX, Wan SX (1984) Effects of lesion of hypothalamic arcuate nucleus region on brain β-endorphin, 5-HT and norepinephrine content and acupuncture analgesia in rats. Acta Physiologica Sinica 36: 42-48 (in Chinese with English abstract)
64. Zhu LX, Li CY, Ji CF, Li WM (1993) The role of OLS in peripheral acupuncture analgesia in arthritic rats. Acupuncture Research 18: 214-218 (in Chinese with English abstract)
65. Zou G, Wu SX, Wang FS, Ji XQ, Zhang ZX, Lu YX, Yi QC (1979a) Increased levels of endorphins in cisternal cerebrospinal fluid of rabbits in acupuncture analgesia. Acta Physiologica Sinica 31: 371-376 (in Chinese with English abstract)
66. Zou G, Zhao DD, Wu SX, Zhang ZX, Lu YX, Wang FS (1979b) Enhancement of acupuncture analgesia with concomitant increase of enkephalin in striatum and hypothalamus by intraventricular bacitracin. Acta Physiologica Sinica 31: 377-381 (in Chinese with English abstract)
67. Zou G, Yi QC, Wang FS, Lu YX, Zhang ZX, Wu SX (1980) Effects of acupuncture analgesia with changes of enkephalin contents in different brain areas. Chinese Science Bulletin 25: 92-94 (in Chinese)