Changes in the binding characteristics of central κ-opioid receptor during the development of 100 Hz electroacupuncture (EA) tolerance in rats

Acta Physiologica Sinica

Volumn 50, Issue 6, 1998, Pages 663-670

  Dong, Yi Na ^a   Mao, Mu Hua ^b   Wang, Xiao Min ^a   Han, Ji Sheng ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Jinggangshan Medical College   (China)

Author keywords

opioid receptor; Analgesia; Electroacupuncture; Tolerance

Indexed keywords

KAPPA OPIATE RECEPTOR;

ANIMAL; ARTICLE; BINDING SITE; BRAIN; ELECTROACUPUNCTURE; FEMALE; MAXIMUM TOLERATED DOSE; MESENCEPHALON; METABOLISM; RAT; SPINAL CORD; WISTAR RAT;

ANIMALS; BINDING SITES; BRAIN; ELECTROACUPUNCTURE; FEMALE; MAXIMUM TOLERATED DOSE; MESENCEPHALON; RATS; RATS, WISTAR; RECEPTORS, OPIOID, KAPPA; SPINAL CORD;

EID: 0040294560     PISSN: 03710874     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Abdelhamid EE, Takemori AE. Characteristics of μ and δ opioid binding sites on striatal slices of morphine-tolerant and -dependent mice. Eur J Pharmacol, 1991, 198: 157-163.
2. De Vries TJ, Tjon Tien Ril GHK, Schoffelmeer ANM, et al. Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering μ-opioid receptor sensitivity. Life Sci, 1993, 52: 1685-1693.
3. Nishino K, Su YF, Chang KJ, et al. Dissociation of mu opioid tolerance from receptor downregulation in rat spinal cord. J Pharmacol Exp Ther, 1990, 253: 67-72.
4. 5] enkephalin binding sites in rat brain membranes. Life Sci, 1982, 31: 2359.
5. Lufty K, Yoburn BC. The role of opioid receptor density in morphine tolerance. J Pharmacol Exp Ther, 1991, 256: 575.
6. Rothman RB, Danks JA, Holaday JW, et al. Morphine tolerance increases μ-noncompetitive δ binding sites. Eur J Pharmacol, 1986, 124: 113-119.
7. Carter BD, Medzihradsky F. Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells. Mol Pharmacol, 1992, 43: 465-473.
8. Tao Pl, Chang LR, Loh HH, et al. Decrease in δ-receptor density in rat brain after chronic [D-Ala 2, D-Leum 5]enkephalin treatment. Brain Res, 1988, 462: 313-320.
9. Tao PL, Law PY, Loh HH. Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment. J Pharmcol Exp Ther, 1987, 240: 809-816.
10. Fei H, Sun SL, Han JS. New evidence supporting differential release of enkephalin and dynorphin by low and high frequency electroacupuncture stimulation. Chin Sci Bull, 1988, 33: 703-705.
11. Fei H, Xie GX, Han JS. Different release of Met-enkephalin and dynorphin in spinal cord by electroacupuncture of different frequencies. Chin Sci Bull, 1986, 31: 1512-1515.
12. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 1976, 72: 248-254.
13. Bhargava HN, Gulati A, Rahmani NH. Effects of morphine tolerance-dependence and abstinence on κ-opiate receptors of rat brain and spinal cord. Biochem Pharmacol, 1991, 42: 1302-1306.
14. Bhargava HN, Gulati A, Ramarao P. Effect of chronic administration of U-50488H in rat brain regions and spinal cord. J Pharmacol Exp Ther, 1989, 251: 21-26.
15. Yoburn BC, Billing B, Duttaroy A. Opioid receptor regulation in mice. J Pharmacol Exp Ther, 1993, 265: 314 -320.
16. Zhu CB, Li XY, Xu SF, et al. Binding sites of mu receptor increased when acupuncture analgesia was enhanced by droperidol: an autoradiographic study. Acta Pharmacol Sin, 1995, 16: 311-314.
17. Bhargava HN, Ramarao P, Gulati A. Effects of morphine in rats treated chronically with U-50488H, a κ opioid receptor agonist. Eur J Pharmacol, 1989, 162: 257-264.
18. Thorat SN, Veeranna, Bhargava HN, et al. Biochemical and behavioral studies on the interaction between μ-and κ-opiate agonists in mice. Brain Res, 1993, 615: 191-198.
19. Puttfarcken PS, Cox BM. Morphine-induced desensitization and down-regulation at mu-receptors in 7315c pituitary tumor cells. Life Sci, 1989, 45: 1937-1942.