-
1
-
-
0034883375
-
Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus
-
Tucker GT, Houston JB, Huang SM, (2001) Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus. Clin Pharmacol Ther 70: 103-114.
-
(2001)
Clin Pharmacol Ther
, vol.70
, pp. 103-114
-
-
Tucker, G.T.1
Houston, J.B.2
Huang, S.M.3
-
2
-
-
0029885913
-
Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications
-
Park BK, Kitteringham NR, Pirmohamed M, Tucker GT, (1996) Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications. Br J Clin Pharmacol 41: 477-491.
-
(1996)
Br J Clin Pharmacol
, vol.41
, pp. 477-491
-
-
Park, B.K.1
Kitteringham, N.R.2
Pirmohamed, M.3
Tucker, G.T.4
-
3
-
-
0034042711
-
Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans
-
Fuhr U, (2000) Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans. Clin Pharmacokinet 38: 493-504.
-
(2000)
Clin Pharmacokinet
, vol.38
, pp. 493-504
-
-
Fuhr, U.1
-
4
-
-
1642441389
-
Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function
-
Orlando R, Piccoli P, De Martin S, Padrini R, Floreani M, et al. (2004) Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function. Clin Pharmacol Ther 75: 80-88.
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 80-88
-
-
Orlando, R.1
Piccoli, P.2
De Martin, S.3
Padrini, R.4
Floreani, M.5
-
5
-
-
33646187731
-
Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine
-
Orlando R, Padrini R, Perazzi M, De Martin S, Piccoli P, et al. (2006) Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine. Clin Pharmacol Ther 79: 489-499.
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 489-499
-
-
Orlando, R.1
Padrini, R.2
Perazzi, M.3
De Martin, S.4
Piccoli, P.5
-
6
-
-
60349085250
-
Irreversible CYP3A inhibition accompanied by plasma protein-binding displacement: a comparative analysis in subjects with normal and impaired liver function
-
Orlando R, De Martin S, Pegoraro P, Quintieri L, Palatini P, (2009) Irreversible CYP3A inhibition accompanied by plasma protein-binding displacement: a comparative analysis in subjects with normal and impaired liver function. Clin Pharmacol Ther 85: 319-326.
-
(2009)
Clin Pharmacol Ther
, vol.85
, pp. 319-326
-
-
Orlando, R.1
De Martin, S.2
Pegoraro, P.3
Quintieri, L.4
Palatini, P.5
-
7
-
-
77956832082
-
The effect of liver disease on inhibitory and plasma protein-binding displacement interactions: an update
-
Palatini P, Orlando R, De Martin S, (2010) The effect of liver disease on inhibitory and plasma protein-binding displacement interactions: an update. Expert Opin Drug Metab Toxicol 6: 1215-1230.
-
(2010)
Expert Opin Drug Metab Toxicol
, vol.6
, pp. 1215-1230
-
-
Palatini, P.1
Orlando, R.2
De Martin, S.3
-
8
-
-
0020020191
-
Major drug interactions: effect of liver disease, alcohol, and malnutrition
-
Hoyumpa AM Jr, Schenker S, (1982) Major drug interactions: effect of liver disease, alcohol, and malnutrition. Annu Rev Med 33: 113-149.
-
(1982)
Annu Rev Med
, vol.33
, pp. 113-149
-
-
Hoyumpa Jr., A.M.1
Schenker, S.2
-
9
-
-
1942421303
-
The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes
-
Elbekai RH, Korashy HM, El-Kadi AO, (2004) The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes. Curr Drug Metab 5: 157-167.
-
(2004)
Curr Drug Metab
, vol.5
, pp. 157-167
-
-
Elbekai, R.H.1
Korashy, H.M.2
El-Kadi, A.O.3
-
10
-
-
38949102772
-
Enzyme inhibition and induction in liver disease
-
Palatini P, De Martin S, Pegoraro P, Orlando R, (2008) Enzyme inhibition and induction in liver disease. Curr Clin Pharmacol 3: 56-69.
-
(2008)
Curr Clin Pharmacol
, vol.3
, pp. 56-69
-
-
Palatini, P.1
De Martin, S.2
Pegoraro, P.3
Orlando, R.4
-
11
-
-
0021176054
-
Microsomal protein synthesis and induction of cytochrome P-450 in cirrhotic rat liver
-
Farrell GC, Zaluzny L, (1984) Microsomal protein synthesis and induction of cytochrome P-450 in cirrhotic rat liver. Aust J Exp Biol Med Sci 62: 291-301.
-
(1984)
Aust J Exp Biol Med Sci
, vol.62
, pp. 291-301
-
-
Farrell, G.C.1
Zaluzny, L.2
-
12
-
-
0025777560
-
Unimpaired induction of drug-metabolizing enzymes in hepatocytes isolated from rats with micronodular cirrhosis
-
Wu ZQ, Piché D, Vallières S, Huet PM, Gascon-Barré M, (1991) Unimpaired induction of drug-metabolizing enzymes in hepatocytes isolated from rats with micronodular cirrhosis. Can J Physiol Pharmacol 69: 426-436.
-
(1991)
Can J Physiol Pharmacol
, vol.69
, pp. 426-436
-
-
Wu, Z.Q.1
Piché, D.2
Vallières, S.3
Huet, P.M.4
Gascon-Barré, M.5
-
13
-
-
0014643503
-
The effect of cirrhosis of the liver on microsomal detoxications and cytochrome P-450
-
Marshall WJ, McLean AE, (1969) The effect of cirrhosis of the liver on microsomal detoxications and cytochrome P-450. Br J Exp Pathol 50: 578-583.
-
(1969)
Br J Exp Pathol
, vol.50
, pp. 578-583
-
-
Marshall, W.J.1
McLean, A.E.2
-
14
-
-
0021964592
-
Temporal relationship between hyperaldosteronism, sodium retention and ascites formation in rats with experimental cirrhosis
-
Jiménez W, Martinez-Pardo A, Arroyo V, Bruix J, Rimola A, et al. (1985) Temporal relationship between hyperaldosteronism, sodium retention and ascites formation in rats with experimental cirrhosis. Hepatology 5: 245-250.
-
(1985)
Hepatology
, vol.5
, pp. 245-250
-
-
Jiménez, W.1
Martinez-Pardo, A.2
Arroyo, V.3
Bruix, J.4
Rimola, A.5
-
15
-
-
0026512122
-
Carbon tetrachloride induced cirrhosis in rats: a useful tool for investigating the pathogenesis of ascites in chronic liver disease
-
Jiménez W, Clária J, Arroyo V, Rodés J, (1992) Carbon tetrachloride induced cirrhosis in rats: a useful tool for investigating the pathogenesis of ascites in chronic liver disease. J Gastroenterol Hepatol 7: 90-97.
-
(1992)
J Gastroenterol Hepatol
, vol.7
, pp. 90-97
-
-
Jiménez, W.1
Clária, J.2
Arroyo, V.3
Rodés, J.4
-
16
-
-
2642510760
-
Role of Aryl Hydrocarbon Receptor-mediated induction of CYP1 enzymes in environmental toxicity and cancer
-
Nebert DW, Dalton TP, Okey AB, Gonzales FJ, (2004) Role of Aryl Hydrocarbon Receptor-mediated induction of CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 279: 23847-23850.
-
(2004)
J Biol Chem
, vol.279
, pp. 23847-23850
-
-
Nebert, D.W.1
Dalton, T.P.2
Okey, A.B.3
Gonzales, F.J.4
-
17
-
-
77953182657
-
Melatonin protects the liver and erythrocytes against oxidative stress in cirrhotic rats
-
Da Rosa DP, Bona S, Simonetto D, Zettler C, Marroni CA, et al. (2010) Melatonin protects the liver and erythrocytes against oxidative stress in cirrhotic rats. Arq Gastroenterol 47: 72-78.
-
(2010)
Arq Gastroenterol
, vol.47
, pp. 72-78
-
-
Da Rosa, D.P.1
Bona, S.2
Simonetto, D.3
Zettler, C.4
Marroni, C.A.5
-
18
-
-
0029039362
-
Histological grading and staging of chronic hepatitis
-
Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, et al. (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22: 696-699.
-
(1995)
J Hepatol
, vol.22
, pp. 696-699
-
-
Ishak, K.1
Baptista, A.2
Bianchi, L.3
Callea, F.4
De Groote, J.5
-
19
-
-
0030586368
-
Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity
-
Pearce RE, McIntyre CJ, Madan A, Sanzgiri U, Draper AJ, et al. (1996) Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity. Arch Biochem Biophys 331: 145-169.
-
(1996)
Arch Biochem Biophys
, vol.331
, pp. 145-169
-
-
Pearce, R.E.1
McIntyre, C.J.2
Madan, A.3
Sanzgiri, U.4
Draper, A.J.5
-
20
-
-
78651165715
-
The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
-
Omura T, Sato R, (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239: 2370-2378.
-
(1964)
J Biol Chem
, vol.239
, pp. 2370-2378
-
-
Omura, T.1
Sato, R.2
-
21
-
-
84871704512
-
Differential inducing effect of benzo[a]pyrene on gene expression and enzyme activity of cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar rats
-
Floreani M, Gabbia D, Barbierato M, De Martin S, Palatini P, (2012) Differential inducing effect of benzo[a]pyrene on gene expression and enzyme activity of cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar rats. Drug Metab Pharmacokinet 27: 640-652.
-
(2012)
Drug Metab Pharmacokinet
, vol.27
, pp. 640-652
-
-
Floreani, M.1
Gabbia, D.2
Barbierato, M.3
De Martin, S.4
Palatini, P.5
-
22
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli UK, (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
23
-
-
0034698372
-
Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection
-
Hanioka N, Tatarazako N, Jinno H, Arizono K, Ando M (2000) Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl 744: 399-406.
-
(2000)
J Chromatogr B Biomed Sci Appl
, vol.744
, pp. 399-406
-
-
Hanioka, N.1
Tatarazako, N.2
Jinno, H.3
Arizono, K.4
Ando, M.5
-
25
-
-
0028106482
-
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
-
Burke MD, Thompson S, Weaver RJ, Wolf CR, Mayer RT, (1994) Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem Pharmacol 48: 923-936.
-
(1994)
Biochem Pharmacol
, vol.48
, pp. 923-936
-
-
Burke, M.D.1
Thompson, S.2
Weaver, R.J.3
Wolf, C.R.4
Mayer, R.T.5
-
26
-
-
0030834058
-
Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors
-
Rendic S, Di Carlo FJ, (1997) Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 29: 413-580.
-
(1997)
Drug Metab Rev
, vol.29
, pp. 413-580
-
-
Rendic, S.1
Di Carlo, F.J.2
-
27
-
-
0030006119
-
Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human and fetal livers and adult lungs
-
Shimada T, Yamazaki H, Mimura M, Wakamiya N, Ueng WF, et al. (1996) Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human and fetal livers and adult lungs. Drug Metab Dispos 24: 515-522.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 515-522
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Wakamiya, N.4
Ueng, W.F.5
-
28
-
-
0035036154
-
Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1
-
Murray GI, Melvin WT, Greenlee WF, Burke MD, (2001) Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1. Annu Rev Pharmacol Toxicol 41: 297-316.
-
(2001)
Annu Rev Pharmacol Toxicol
, vol.41
, pp. 297-316
-
-
Murray, G.I.1
Melvin, W.T.2
Greenlee, W.F.3
Burke, M.D.4
-
29
-
-
0028801475
-
Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease
-
George J, Murray M, Byth K, Farrell GC, (1995) Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease. Hepatology 21: 120-128.
-
(1995)
Hepatology
, vol.21
, pp. 120-128
-
-
George, J.1
Murray, M.2
Byth, K.3
Farrell, G.C.4
-
30
-
-
0030941567
-
Selective centrilobular expression of the aryl hydrocarbon receptor in rat liver
-
Lindros KO, Oinonen T, Johansson I, Ingelman-Sundberg M, (1997) Selective centrilobular expression of the aryl hydrocarbon receptor in rat liver. J Pharmacol Exp Ther 280: 506-511.
-
(1997)
J Pharmacol Exp Ther
, vol.280
, pp. 506-511
-
-
Lindros, K.O.1
Oinonen, T.2
Johansson, I.3
Ingelman-Sundberg, M.4
-
31
-
-
0035894283
-
In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model
-
Franc MA, Pohjanvirta R, Tuomisto J, Okey AB, (2001) In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model. Biochem Pharmacol 62: 1565-1578.
-
(2001)
Biochem Pharmacol
, vol.62
, pp. 1565-1578
-
-
Franc, M.A.1
Pohjanvirta, R.2
Tuomisto, J.3
Okey, A.B.4
-
32
-
-
80052847569
-
Novel advances in cytochrome P450 research
-
Singh D, Kashyap A, Pandey RV, Saini KS, (2011) Novel advances in cytochrome P450 research. Drug Discov Today 16: 793-799.
-
(2011)
Drug Discov Today
, vol.16
, pp. 793-799
-
-
Singh, D.1
Kashyap, A.2
Pandey, R.V.3
Saini, K.S.4
-
34
-
-
0028928044
-
Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis
-
George J, Liddle C, Murray M, Byth K, Farrell GC, (1995) Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis. Biochem Pharmacol 49: 873-881.
-
(1995)
Biochem Pharmacol
, vol.49
, pp. 873-881
-
-
George, J.1
Liddle, C.2
Murray, M.3
Byth, K.4
Farrell, G.C.5
-
35
-
-
0033074472
-
Effects of disease on expression and regulation of CYPs
-
Farrell G, (1999) Effects of disease on expression and regulation of CYPs. Mol Aspects Med 20: 55-70.
-
(1999)
Mol Aspects Med
, vol.20
, pp. 55-70
-
-
Farrell, G.1
-
36
-
-
57049161412
-
Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction
-
Verbeeck RK, (2008) Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol 64: 1147-1161.
-
(2008)
Eur J Clin Pharmacol
, vol.64
, pp. 1147-1161
-
-
Verbeeck, R.K.1
|