The proinflammatory cytokines interleukin-1 α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes

Biological Chemistry

Volumn 394, Issue 2, 2013, Pages 307-316

  Caglic, Dejan ^a,e,f   Turk, Boris ^a   Repnik, Urska ^a   Kosec, Gregor ^a,h   Vasiljeva, Olga ^a   Turk, Vito ^a,e   Jedeszko, Christopher ^b,g   Sloane, Bonnie F ^b   Miniejew, Catherine ^c   Kindermann, Maik ^c   Wendt, K Ulrich ^c   Goldring, Mary B ^d  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HMR Deutschland GmbH   (Germany)

^d HOSPITAL FOR SPECIAL SURGERY   (United States)

^e Center of Excellence for Integrated Approaches in Chemistry and Biology of Proteins   (Slovenia)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

^g UNIVERSITY OF TORONTO   (Canada)

^h ACIES BIO D O O   (Slovenia)

Author keywords

Activity based probe; Cathepsin; Chondrocyte; Osteoarthritis; Proinflammatory cytokine

Indexed keywords

CATHEPSIN S; COLLAGEN TYPE 2; INTERLEUKIN 1ALPHA; TUMOR NECROSIS FACTOR ALPHA; CATHEPSIN;

ANIMAL CELL; ARTICLE; BIOLUMINESCENCE; CARTILAGE CELL; CELL STIMULATION; CONTROLLED STUDY; ENZYME RELEASE; EXTRACELLULAR MATRIX; GENE PROBE; IN VIVO STUDY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SUPERNATANT; BIOSYNTHESIS; CELL CULTURE; HUMAN; INFLAMMATION; METABOLISM; SECRETION (PROCESS);

CATHEPSINS; CELLS, CULTURED; CHONDROCYTES; HUMANS; INFLAMMATION; INTERLEUKIN-1ALPHA; PROTEOLYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84876539526     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2012-0283     Document Type: Article

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