Analysis of sex hormone genes reveals gender differences in the genetic etiology of blood pressure salt sensitivity: The gensalt study

American Journal of Hypertension

Volumn 26, Issue 2, 2013, Pages 191-200

  Kelly, Tanika N ^a   Rebholz, Casey M ^a   Gu, Dongfeng ^b   Hixson, James E ^c   Rice, Treva K ^d   Cao, Jie ^b   Chen, Jichun ^b   Li, Jianxin ^b   Lu, Fanghong ^e   Ma, Jixiang ^f   Mu, Jianjun ^g   Whelton, Paul K ^a   He, Jiang ^a  

^a TULANE UNIVERSITY   (United States)

^b FUWAI HOSPITAL   (China)

^c UNIVERSITY OF TEXAS   (United States)

^d WASHINGTON UNIVERSITY   (United States)

^e Academy of Medical Sciences   (China)

^f Shandong Center for Diseases Control and Prevention   (China)

^g XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

blood pressure; dietary sodium; gender; genetics; hypertension; polymorphism; salt sensitivity

Indexed keywords

ALDOSTERONE SYNTHASE; ANDROGEN RECEPTOR; AROMATASE; CATECHOL METHYLTRANSFERASE; CYTOCHROME P450 17; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 3A; CYTOCHROME P450 4A; EPOXIDE HYDROLASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FOLLITROPIN BETA SUBUNIT; FOLLITROPIN RECEPTOR BINDING INHIBITOR; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; LUTEINIZING HORMONE BETA SUBUNIT; LUTEINIZING HORMONE RECEPTOR; PHOSPHODIESTERASE; PROGESTERONE RECEPTOR; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; STEROID 5ALPHA REDUCTASE 2; STEROIDOGENIC ACUTE REGULATORY PROTEIN; SULFOTRANSFERASE;

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CHINESE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIETARY INTAKE; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HIGH SODIUM INTAKE; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM INTAKE; SODIUM RESTRICTION; SPHYGMOMANOMETER; SYSTOLIC BLOOD PRESSURE;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; CHINA; ESTROGEN RECEPTOR ALPHA; FEMALE; GENES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GONADAL STEROID HORMONES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX CHARACTERISTICS; SEX FACTORS; SODIUM CHLORIDE, DIETARY;

EID: 84876529109     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hps018     Document Type: Article

References (40)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: Analysis of worldwide data. Lancet 2005;365:217-223. (Pubitemid 40138015)
2. Danaei G, Finucane MM, Lin JK, Singh GM, Paciorek CJ, Cowan MJ, Farzadfar F, Stevens GA, Lim SS, Riley LM, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating G. National, regional, and global trends in systolic blood pressure since 1980: Systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants. Lancet 2011;377:568-577.
3. Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay W, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RTH, Nabika T, Gu D, Chang L, Kokkubo Y, Huang W, Ohnaka K, Yoamori Y, Nakashima E, Lee JY, Seielstad M, Isono M, Hisxon JE, Chen YT, Miki T, Zhang X, Sugiyama T, Jeon JP, Liu JJ, Takayanagi R, Kim SS, Aung T, Sung YJ, Jin L, Wong TY, Han BG, Kobayashi S, Ogihara T, Zhu D, Iwai N, Wu JY, Teo YY, Tai ES, Cho YS, He J. Meta-analysis identifies five novel loci associated with blood pressure in East Ssians. Nat Genet 2011;43:531-538.
4. Whelton PK, He J, Appel LJ, Cutler JA, Havas S, Kotchen TA, Roccella EJ, Stout R, Vallbona C, Winston MC, Karimbakas J, National High Blood Pressure Education Program Coordinating C. Primary prevention of hypertension: Clinical and public health advisory from the National High Blood Pressure Education Program. JAMA 2002;288: 1882-1888. (Pubitemid 35168144)
5. He J, Whelton PK. Salt intake, hypertension and risk of cardiovascular disease: An important public health challenge. Int J Epidemiol 2002;31:327-331. (Pubitemid 34537787)
6. Chobanian AV, Hill M. National heart, lung, and blood institute workshop on sodium and blood pressure: A critical review of current scientific evidence. Hypertension 2000;35:858-863. (Pubitemid 30303940)
7. Cutler JA, Follmann D, Allender PS. Randomized trials of sodium reduction: An overview. Am J Clin Nutr 1997;65:643S-651S. (Pubitemid 27063065)
8. Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obarzanek E, Conlin PR, Miller ER, 3rd, Simons-Morton DG, Karanja N, Lin PH, Group DA-SCR. Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (dash) diet. Dash-Sodium Collaborative Research Group. NEJM 2001;344:3-10. (Pubitemid 32064838)
9. Weinberger MH. Salt sensitivity of blood pressure in humans. Hypertension 1996;27:481-490. (Pubitemid 26084617)
10. Barba G, Galletti F, Cappuccio FP, Siani A, Venezia A, Versiero M, Della Valle E, Sorrentino P, Tarantino G, Farinaro E, Strazzullo P. Incidence of hypertension in individuals with different blood pressure salt-sensitivity: Results of a 15-year follow-up study. J Hypertens 2007;25:1465-1471. (Pubitemid 46918835)
11. Morimoto A, Uzu T, Fujii T, Nishimura M, Kuroda S, Nakamura S, Inenaga T, Kimura G. Sodium sensitivity and cardiovascular events in patients with essential hypertension. Lancet 1997;350:1734-1737. (Pubitemid 28036672)
12. Weinberger MH, Fineberg NS, Fineberg SE, Weinberger M. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension 2001;37:429-432. (Pubitemid 32199006)
13. Wright JT, Jr., Rahman M, Scarpa A, Fatholahi M, Griffin V, Jean-Baptiste R, Islam M, Eissa M, White S, Douglas JG. Determinants of salt sensitivity in black and white normotensive and hypertensive women. Hypertension 2003;42:1087-1092. (Pubitemid 37549060)
14. Obarzanek E, Proschan MA, Vollmer WM, Moore TJ, Sacks FM, Appel LJ, Svetkey LP, Most-Windhauser MM, Cutler JA. Individual blood pressure responses to changes in salt intake: Results from the dashsodium trial. Hypertension 2003;42:459-467. (Pubitemid 37237339)
15. He J, Gu D, Chen J, Jaquish CE, Rao DC, Hixson JE, Chen J-c, Duan X, Huang J-f, Chen C-S, Kelly TN, Bazzano LA, Whelton PK, GenSalt Collaborative Research G. Gender difference in blood pressure responses to dietary sodium intervention in the gensalt study. J Hypertens 2009;27:48-54.
16. Chen J, Gu D, Huang J, Rao DC, Jaquish CE, Hixson JE, Chen C-S, Chen J, Lu F, Hu D, Rice T, Kelly TN, Hamm LL, Whelton PK, He J, GenSalt Collaborative Research G. Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in china: A dietary intervention study. Lancet 2009;373:829-835.
17. Pechere-Bertschi A, Maillard M, Stalder H, Brunner HR, Burnier M. Renal segmental tubular response to salt during the normal menstrual cycle. Kidney Int 2002;61:425-431. (Pubitemid 34102582)
18. Hinojosa-Laborde C, Lange DL, Haywood JR. Role of female sex hormones in the development and reversal of dahl hypertension. Hypertension 2000;35:484-489. (Pubitemid 30054221)
19. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. NEJM 1999;340:1801-1811. (Pubitemid 29266405)
20. Zhao L, Stamler J, Yan LL, Zhou B, Wu Y, Liu K, Daviglus ML, Dennis BH, Elliott P, Ueshima H, Yang J, Zhu L, Guo D, Group IR. Blood pressure differences between northern and Southern Chinese: Role of dietary factors: The international study on macronutrients and blood pressure. Hypertension 2004;43:1332-1337. (Pubitemid 38691758)
21. GenSalt Collaborative Research G. Gensalt: Rationale, design, methods and baseline characteristics of study participants. J Hum Hypertens 2007;21:639-646.
22. Perloff D, Grim C, Flack J, Frohlich ED, Hill M, McDonald M, Morgenstern BZ. Human blood pressure determination by sphygmomanometry. Circulation 1993;88:2460-2470.
23. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: Analysis and visualization of ld and haplotype maps. Bioinformatics 2005;21:263-265. (Pubitemid 40202029)
24. Nishida N, Koike A, Tajima A, Ogasawara Y, Ishibashi Y, Uehara Y, Inoue I, Tokunaga K. Evaluating the performance of affymetrix snp array 6.0 platform with 400 Japanese individuals. BMC Genomics 2008;9:431.
25. Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest 1999;103:401-406. (Pubitemid 29069990)
26. Mendelsohn ME, Rosano GMC. Hormonal regulation of normal vascular tone in males. Circ Res 2003;93:1142-1145. (Pubitemid 37543054)
27. Pare G, Krust A, Karas RH, Dupont S, Aronovitz M, Chambon P, Mendelsohn ME. Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res 2002;90:1087-1092. (Pubitemid 34627907)
28. Lehrer S, Rabin J, Kalir T, Schachter BS. Estrogen receptor variant and hypertension in women. Hypertension 1993;21:439-441 (Pubitemid 23095155)
29. Ellis JA, Infantino T, Harrap SB. Sex-dependent association of blood pressure with oestrogen receptor genes eralpha and erbeta. J Hypertens 2004;22:1127-1131. (Pubitemid 38721004)
30. Peter I, Shearman AM, Zucker DR, Schmid CH, Demissie S, Cupples LA, Larson MG, Vasan RS, D'Agostino RB, Karas RH, Mendelsohn ME, Housman DE, Levy D. Variation in estrogen-related genes and crosssectional and longitudinal blood pressure in the framingham heart study. J Hypertens 2005;23:2193-2200. (Pubitemid 41666749)
31. Xu H, Hou X, Wang N, Hui B, Jin J, Yun S, Wang X, He X, He J, Zhang S, Han Y. Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population. Clin Chim Acta 2008;395:130-133.
32. Tamura M, Nakayama T, Sato I, Sato N, Izawa N, Hishiki M, Mizutani Y, Furuya K, Yamamoto T. Haplotype-based case-control study of estrogen receptor alpha (esr1) gene and pregnancy-induced hypertension. Hypertens Res 2008;31:221-228. (Pubitemid 351461100)
33. Hayashi K, Maeda S, Iemitsu M, Otsuki T, Sugawara J, Tanabe T, Miyauchi T, Kuno S, Ajisaka R, Matsuda M. Sex differences in the relationship between estrogen receptor alpha gene polymorphisms and arterial stiffness in older humans. Am J Hypertens 2007;20:650-656. (Pubitemid 46777262)
34. Molvarec A, Ver A, Fekete A, Rosta K, Derzbach L, Derzsy Z, Karadi I, Rigo J, Jr. Association between estrogen receptor alpha (esr1) gene polymorphisms and severe preeclampsia. Hypertens Res 2007;30:205-211. (Pubitemid 46605444)
35. Figtree GA, Kindmark A, Lind L, Grundberg E, Speller B, Robinson BG, Channon KM, Watkins H. Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension. J Steroid Biochem Mol Biol 2007;103:110-118. (Pubitemid 46149299)
36. Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ. Estrogen receptor alpha gene variation and the risk of stroke. Stroke 2005;36:2281-2282. (Pubitemid 41429261)
37. Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D. Association between estrogen receptor alpha gene variation and cardiovascular disease. JAMA 2003;290:2263-2270. (Pubitemid 37430558)
38. Xu Z, Taylor JA. Snpinfo: Integrating gwas and candidate gene information into functional snp selection for genetic association studies. Nucleic Acids Res 2009;37:W600-W605.
39. Ma Y, Qiao X, Falone AE, Reslan OM, Sheppard SJ, Khalil RA. Genderspecific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat. Cell Physiol Biochem 2010;26:457-470.
40. Hodges YK, Tung L, Yan XD, Graham JD, Horwitz KB, Horwitz LD. Estrogen receptors alpha and beta: Prevalence of estrogen receptor beta mrna in human vascular smooth muscle and transcriptional effects. Circulation 2000;101:1792-1798. (Pubitemid 30213100)